Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.
Lee, HJ
Gallego-Ortega, D
Ledger, A
Schramek, D
Joshi, P
Szwarc, MM
Cho, C
Lydon, JP
Khokha, R
Penninger, JM
Ormandy, CJ
- Publisher:
- COMPANY BIOLOGISTS LTD
- Publication Type:
- Journal Article
- Citation:
- Development, 2013, 140, (7), pp. 1397-1401
- Issue Date:
- 2013-04
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HJ | |
dc.contributor.author | Gallego-Ortega, D | |
dc.contributor.author | Ledger, A | |
dc.contributor.author | Schramek, D | |
dc.contributor.author | Joshi, P | |
dc.contributor.author | Szwarc, MM | |
dc.contributor.author | Cho, C | |
dc.contributor.author | Lydon, JP | |
dc.contributor.author | Khokha, R | |
dc.contributor.author | Penninger, JM | |
dc.contributor.author | Ormandy, CJ | |
dc.date.accessioned | 2023-02-27T19:33:44Z | |
dc.date.available | 2023-02-27T19:33:44Z | |
dc.date.issued | 2013-04 | |
dc.identifier.citation | Development, 2013, 140, (7), pp. 1397-1401 | |
dc.identifier.issn | 0950-1991 | |
dc.identifier.issn | 1477-9129 | |
dc.identifier.uri | http://hdl.handle.net/10453/166472 | |
dc.description.abstract | Progesterone-RankL paracrine signaling has been proposed as a driver of stem cell expansion in the mammary gland, and Elf5 is essential for the differentiation of mammary epithelial progenitor cells. We demonstrate that Elf5 expression is induced by progesterone and that Elf5 and progesterone cooperate to promote alveolar development. The progesterone receptor and Elf5 are expressed in a mutually exclusive pattern, and we identify RankL as the paracrine mediator of the effects of progesterone on Elf5 expression in CD61+ progenitor cells and their consequent differentiation. Blockade of RankL action prevented progesterone-induced side branching and the expansion of Elf5(+) mature luminal cells. These findings describe a mechanism by which steroid hormones can produce the expansion of steroid hormone receptor-negative mammary epithelial cells. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | COMPANY BIOLOGISTS LTD | |
dc.relation.ispartof | Development | |
dc.relation.isbasedon | 10.1242/dev.088948 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 06 Biological Sciences, 11 Medical and Health Sciences | |
dc.subject.mesh | Animals | |
dc.subject.mesh | DNA-Binding Proteins | |
dc.subject.mesh | Epithelial Cells | |
dc.subject.mesh | Female | |
dc.subject.mesh | Gene Expression Regulation, Developmental | |
dc.subject.mesh | Mammary Glands, Animal | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Mice, Transgenic | |
dc.subject.mesh | Progesterone | |
dc.subject.mesh | RANK Ligand | |
dc.subject.mesh | Receptors, Progesterone | |
dc.subject.mesh | Stem Cells | |
dc.subject.mesh | Transcription Factors | |
dc.subject.mesh | Up-Regulation | |
dc.subject.mesh | Mammary Glands, Animal | |
dc.subject.mesh | Epithelial Cells | |
dc.subject.mesh | Stem Cells | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Mice, Transgenic | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Progesterone | |
dc.subject.mesh | DNA-Binding Proteins | |
dc.subject.mesh | Receptors, Progesterone | |
dc.subject.mesh | Transcription Factors | |
dc.subject.mesh | Gene Expression Regulation, Developmental | |
dc.subject.mesh | Up-Regulation | |
dc.subject.mesh | Female | |
dc.subject.mesh | RANK Ligand | |
dc.title | Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. | |
dc.type | Journal Article | |
utslib.citation.volume | 140 | |
utslib.location.activity | England | |
utslib.for | 06 Biological Sciences | |
utslib.for | 11 Medical and Health Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2023-02-27T19:33:42Z | |
pubs.issue | 7 | |
pubs.publication-status | Published | |
pubs.volume | 140 | |
utslib.citation.issue | 7 |
Abstract:
Progesterone-RankL paracrine signaling has been proposed as a driver of stem cell expansion in the mammary gland, and Elf5 is essential for the differentiation of mammary epithelial progenitor cells. We demonstrate that Elf5 expression is induced by progesterone and that Elf5 and progesterone cooperate to promote alveolar development. The progesterone receptor and Elf5 are expressed in a mutually exclusive pattern, and we identify RankL as the paracrine mediator of the effects of progesterone on Elf5 expression in CD61+ progenitor cells and their consequent differentiation. Blockade of RankL action prevented progesterone-induced side branching and the expansion of Elf5(+) mature luminal cells. These findings describe a mechanism by which steroid hormones can produce the expansion of steroid hormone receptor-negative mammary epithelial cells.
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