Feasibility evaluation of a Zn-Cu alloy for intrauterine devices: In vitro and in vivo studies.

Bao, G; Wang, K; Yang, L; He, J; He, B; Xu, X; Zheng, Y

Feasibility evaluation of a Zn-Cu alloy for intrauterine devices: In vitro and in vivo studies.

Bao, G Wang, K Yang, L He, J He, B Xu, X

Zheng, Y

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Publisher:: ELSEVIER SCI LTD
Publication Type:: Journal Article
Citation:: Acta Biomater, 2022, 142, pp. 374-387
Issue Date:: 2022-04-01

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Field	Value	Language
dc.contributor.author	Bao, G
dc.contributor.author	Wang, K
dc.contributor.author	Yang, L
dc.contributor.author	He, J
dc.contributor.author	He, B
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.contributor.author	Zheng, Y
dc.date.accessioned	2023-02-27T23:43:11Z
dc.date.available	2022-01-25
dc.date.available	2023-02-27T23:43:11Z
dc.date.issued	2022-04-01
dc.identifier.citation	Acta Biomater, 2022, 142, pp. 374-387
dc.identifier.issn	1742-7061
dc.identifier.issn	1878-7568
dc.identifier.uri	http://hdl.handle.net/10453/166479
dc.description.abstract	The comprehensively adopted copper-containing intrauterine devices (Cu-IUDs) present typical adverse effects such as bleeding and pain at the initial stage of post-implantation. The replacement of Cu material is demanded. Zinc and its alloys, the emerging biodegradable materials, exhibited contraceptive effects since 1969. In this work, we evaluated the feasibility of bulk Zn alloys as IUD active material. Using pure Cu and pure Zn as control groups, we investigated the contraceptive performance of Zn-0.5Cu and Zn-1Cu alloys via in vitro and in vivo tests. The results showed that the main corrosion product of Zn-Cu alloys is ZnO from both in vitro and in vivo studies. CaZn2(PO4)2·2H2O is formed atop after long-term immersion in simulated uterine fluid, whereas CaCO3 is generally formed atop after implantation in the rat uterine environment. The cytocompatibility of the Zn-1Cu alloy was significantly higher than that of the pure Zn and pure Cu to the human endometrial epithelial cell lines. Furthermore, the in vivo results showed that the Zn-1Cu alloy presented much improved histocompatibility, least damage and the fastest recovery on endometrium structure in comparison to pure Zn, Zn-0.5Cu and pure Cu. The systematic and comparing studies suggest that Zn-1Cu alloy can be considered as a possible candidate for IUD with great biochemical and biocompatible properties as well as high contraceptive effectiveness. STATEMENT OF SIGNIFICANCE: The existing adverse effects with the intrinsic properties of copper materials for copper-containing intrauterine devices (Cu-IUD) are of concerns in their employment. Such as burst release of cupric ions (Cu2+) at the initial stage of the Cu-IUD. Zinc and its alloys which have been emerging as a potential biodegradable material exhibited contraceptive effects since 1969. In this study, Zn-1Cu alloys displayed significantly improved biocompatibility with human uterus cells and a decreased inflammatory response within the uterus. Therefore, high antifertility efficacy of the Zn-1Cu alloy was well maintained, while the adverse effects are significantly eased, suggesting that the Zn-1Cu alloy is promising for IUD.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCI LTD
dc.relation.ispartof	Acta Biomater
dc.relation.isbasedon	10.1016/j.actbio.2022.01.053
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Biomedical Engineering
dc.subject.mesh	Alloys
dc.subject.mesh	Animals
dc.subject.mesh	Contraceptive Agents
dc.subject.mesh	Copper
dc.subject.mesh	Corrosion
dc.subject.mesh	Feasibility Studies
dc.subject.mesh	Female
dc.subject.mesh	Materials Testing
dc.subject.mesh	Rats
dc.subject.mesh	Zinc
dc.subject.mesh	Animals
dc.subject.mesh	Rats
dc.subject.mesh	Copper
dc.subject.mesh	Zinc
dc.subject.mesh	Alloys
dc.subject.mesh	Contraceptive Agents
dc.subject.mesh	Feasibility Studies
dc.subject.mesh	Materials Testing
dc.subject.mesh	Corrosion
dc.subject.mesh	Female
dc.subject.mesh	Alloys
dc.subject.mesh	Animals
dc.subject.mesh	Contraceptive Agents
dc.subject.mesh	Copper
dc.subject.mesh	Corrosion
dc.subject.mesh	Feasibility Studies
dc.subject.mesh	Female
dc.subject.mesh	Materials Testing
dc.subject.mesh	Rats
dc.subject.mesh	Zinc
dc.title	Feasibility evaluation of a Zn-Cu alloy for intrauterine devices: In vitro and in vivo studies.
dc.type	Journal Article
utslib.citation.volume	142
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-27T23:43:09Z
pubs.publication-status	Published
pubs.volume	142

Abstract:

The comprehensively adopted copper-containing intrauterine devices (Cu-IUDs) present typical adverse effects such as bleeding and pain at the initial stage of post-implantation. The replacement of Cu material is demanded. Zinc and its alloys, the emerging biodegradable materials, exhibited contraceptive effects since 1969. In this work, we evaluated the feasibility of bulk Zn alloys as IUD active material. Using pure Cu and pure Zn as control groups, we investigated the contraceptive performance of Zn-0.5Cu and Zn-1Cu alloys via in vitro and in vivo tests. The results showed that the main corrosion product of Zn-Cu alloys is ZnO from both in vitro and in vivo studies. CaZn2(PO4)2·2H2O is formed atop after long-term immersion in simulated uterine fluid, whereas CaCO3 is generally formed atop after implantation in the rat uterine environment. The cytocompatibility of the Zn-1Cu alloy was significantly higher than that of the pure Zn and pure Cu to the human endometrial epithelial cell lines. Furthermore, the in vivo results showed that the Zn-1Cu alloy presented much improved histocompatibility, least damage and the fastest recovery on endometrium structure in comparison to pure Zn, Zn-0.5Cu and pure Cu. The systematic and comparing studies suggest that Zn-1Cu alloy can be considered as a possible candidate for IUD with great biochemical and biocompatible properties as well as high contraceptive effectiveness. STATEMENT OF SIGNIFICANCE: The existing adverse effects with the intrinsic properties of copper materials for copper-containing intrauterine devices (Cu-IUD) are of concerns in their employment. Such as burst release of cupric ions (Cu2+) at the initial stage of the Cu-IUD. Zinc and its alloys which have been emerging as a potential biodegradable material exhibited contraceptive effects since 1969. In this study, Zn-1Cu alloys displayed significantly improved biocompatibility with human uterus cells and a decreased inflammatory response within the uterus. Therefore, high antifertility efficacy of the Zn-1Cu alloy was well maintained, while the adverse effects are significantly eased, suggesting that the Zn-1Cu alloy is promising for IUD.

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http://hdl.handle.net/10453/166479