Topical hemostatic materials for coagulopathy.

Hu, B; Bao, G; Xu, X; Yang, K

Topical hemostatic materials for coagulopathy.

Hu, B Bao, G

Xu, X

Yang, K

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Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: J Mater Chem B, 2022, 10, (12), pp. 1946-1959
Issue Date:: 2022-03-23

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Field	Value	Language
dc.contributor.author	Hu, B
dc.contributor.author	Bao, G https://orcid.org/0000-0001-5103-5009
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.contributor.author	Yang, K
dc.date.accessioned	2023-02-27T23:48:05Z
dc.date.available	2023-02-27T23:48:05Z
dc.date.issued	2022-03-23
dc.identifier.citation	J Mater Chem B, 2022, 10, (12), pp. 1946-1959
dc.identifier.issn	2050-750X
dc.identifier.issn	2050-7518
dc.identifier.uri	http://hdl.handle.net/10453/166480
dc.description.abstract	Medical science has witnessed significant progress in the development of hemostatic materials, which save lives by supporting natural hemostatic ability. However, for the hemostasis under coagulopathy where natural hemostatic ability is dysfunctional, many conventional hemostatic materials are ineffective. Recent advances in hemostatic materials, including fibrin, chitosan, gelatin, nanoparticles, PEG derivatives, elaborate liposomes, oxidized cellulose, and fibrinogen-specific binding polymers, have led to significant success in tackling bleeding in coagulopathy. In this review, we present a thorough analysis on the hemostatic mechanisms and the design principles of hemostatic materials for coagulopathy, survey their remarkable success, and briefly discuss the challenges and perspectives for their clinical translation.
dc.format	Electronic
dc.language	eng
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation.ispartof	J Mater Chem B
dc.relation.isbasedon	10.1039/d1tb02523f
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0903 Biomedical Engineering
dc.subject.mesh	Chitosan
dc.subject.mesh	Gelatin
dc.subject.mesh	Hemorrhage
dc.subject.mesh	Hemostasis
dc.subject.mesh	Hemostatics
dc.subject.mesh	Humans
dc.subject.mesh	Humans
dc.subject.mesh	Hemorrhage
dc.subject.mesh	Chitosan
dc.subject.mesh	Gelatin
dc.subject.mesh	Hemostatics
dc.subject.mesh	Hemostasis
dc.title	Topical hemostatic materials for coagulopathy.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0903 Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2023-02-27T23:48:04Z
pubs.issue	12
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	12

Abstract:

Medical science has witnessed significant progress in the development of hemostatic materials, which save lives by supporting natural hemostatic ability. However, for the hemostasis under coagulopathy where natural hemostatic ability is dysfunctional, many conventional hemostatic materials are ineffective. Recent advances in hemostatic materials, including fibrin, chitosan, gelatin, nanoparticles, PEG derivatives, elaborate liposomes, oxidized cellulose, and fibrinogen-specific binding polymers, have led to significant success in tackling bleeding in coagulopathy. In this review, we present a thorough analysis on the hemostatic mechanisms and the design principles of hemostatic materials for coagulopathy, survey their remarkable success, and briefly discuss the challenges and perspectives for their clinical translation.

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http://hdl.handle.net/10453/166480