Elastic Fibers in the Intervertebral Disc: From Form to Function and toward Regeneration.

Cyril, D; Giugni, A; Bangar, SS; Mirzaeipoueinak, M; Shrivastav, D; Sharabi, M; Tipper, JL; Tavakoli, J

Elastic Fibers in the Intervertebral Disc: From Form to Function and toward Regeneration.

Cyril, D Giugni, A Bangar, SS Mirzaeipoueinak, M Shrivastav, D Sharabi, M Tipper, JL Tavakoli, J

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Int J Mol Sci, 2022, 23, (16), pp. 8931
Issue Date:: 2022-08-11

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Field	Value	Language
dc.contributor.author	Cyril, D
dc.contributor.author	Giugni, A
dc.contributor.author	Bangar, SS
dc.contributor.author	Mirzaeipoueinak, M
dc.contributor.author	Shrivastav, D
dc.contributor.author	Sharabi, M
dc.contributor.author	Tipper, JL
dc.contributor.author	Tavakoli, J https://orcid.org/0000-0002-0696-6530
dc.date.accessioned	2023-03-12T21:17:14Z
dc.date.available	2022-08-08
dc.date.available	2023-03-12T21:17:14Z
dc.date.issued	2022-08-11
dc.identifier.citation	Int J Mol Sci, 2022, 23, (16), pp. 8931
dc.identifier.issn	1422-0067
dc.identifier.issn	1422-0067
dc.identifier.uri	http://hdl.handle.net/10453/167062
dc.description.abstract	Despite extensive efforts over the past 40 years, there is still a significant gap in knowledge of the characteristics of elastic fibers in the intervertebral disc (IVD). More studies are required to clarify the potential contribution of elastic fibers to the IVD (healthy and diseased) function and recommend critical areas for future investigations. On the other hand, current IVD in-vitro models are not true reflections of the complex biological IVD tissue and the role of elastic fibers has often been ignored in developing relevant tissue-engineered scaffolds and realistic computational models. This has affected the progress of IVD studies (tissue engineering solutions, biomechanics, fundamental biology) and translation into clinical practice. Motivated by the current gap, the current review paper presents a comprehensive study (from the early 1980s to 2022) that explores the current understanding of structural (multi-scale hierarchy), biological (development and aging, elastin content, and cell-fiber interaction), and biomechanical properties of the IVD elastic fibers, and provides new insights into future investigations in this domain.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Int J Mol Sci
dc.relation.isbasedon	10.3390/ijms23168931
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0399 Other Chemical Sciences, 0604 Genetics, 0699 Other Biological Sciences
dc.subject.classification	Chemical Physics
dc.subject.mesh	Elastic Tissue
dc.subject.mesh	Humans
dc.subject.mesh	Intervertebral Disc
dc.subject.mesh	Intervertebral Disc Degeneration
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Elastic Tissue
dc.subject.mesh	Humans
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Intervertebral Disc
dc.subject.mesh	Intervertebral Disc Degeneration
dc.subject.mesh	Elastic Tissue
dc.subject.mesh	Humans
dc.subject.mesh	Intervertebral Disc
dc.subject.mesh	Intervertebral Disc Degeneration
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.title	Elastic Fibers in the Intervertebral Disc: From Form to Function and toward Regeneration.
dc.type	Journal Article
utslib.citation.volume	23
utslib.location.activity	Switzerland
utslib.for	0399 Other Chemical Sciences
utslib.for	0604 Genetics
utslib.for	0699 Other Biological Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2023-03-12T21:17:12Z
pubs.issue	16
pubs.publication-status	Published online
pubs.volume	23
utslib.citation.issue	16

Abstract:

Despite extensive efforts over the past 40 years, there is still a significant gap in knowledge of the characteristics of elastic fibers in the intervertebral disc (IVD). More studies are required to clarify the potential contribution of elastic fibers to the IVD (healthy and diseased) function and recommend critical areas for future investigations. On the other hand, current IVD in-vitro models are not true reflections of the complex biological IVD tissue and the role of elastic fibers has often been ignored in developing relevant tissue-engineered scaffolds and realistic computational models. This has affected the progress of IVD studies (tissue engineering solutions, biomechanics, fundamental biology) and translation into clinical practice. Motivated by the current gap, the current review paper presents a comprehensive study (from the early 1980s to 2022) that explores the current understanding of structural (multi-scale hierarchy), biological (development and aging, elastin content, and cell-fiber interaction), and biomechanical properties of the IVD elastic fibers, and provides new insights into future investigations in this domain.

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http://hdl.handle.net/10453/167062