Computational Inertial Microfluidics: Optimal Design for Particle Separation

Saha, SC; Francis, I; Nassir, T

Computational Inertial Microfluidics: Optimal Design for Particle Separation

Saha, SC Francis, I

Nassir, T

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Fluids, 2022, 7, (9), pp. 308
Issue Date:: 2022-09-01

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Field	Value	Language
dc.contributor.author	Saha, SC
dc.contributor.author	Francis, I https://orcid.org/0000-0002-6382-4037
dc.contributor.author	Nassir, T
dc.date.accessioned	2023-03-12T21:40:25Z
dc.date.available	2023-03-12T21:40:25Z
dc.date.issued	2022-09-01
dc.identifier.citation	Fluids, 2022, 7, (9), pp. 308
dc.identifier.issn	2311-5521
dc.identifier.issn	2311-5521
dc.identifier.uri	http://hdl.handle.net/10453/167068
dc.description.abstract	Following the emergence of many blood transfusion-associated diseases, novel passive cell separation technologies, such as microfluidic devices, are increasingly designed and optimized to separate red blood cells (RBCs) and white blood cells (WBCs) from whole blood. These systems allow for the rapid diagnosis of diseases without relying on complicated and expensive hematology instruments such as flow microscopes, coagulation analyzers, and cytometers. The inertia effect and the impact of intrinsic hydrodynamic forces, the Dean drag force (FD), and the inertial lift force (FL) on the migration of particles within curved and complex confined channels have been explored theoretically, computationally, and experimentally. This study aimed to optimize the dimensions of a microfluidic channel for fast particle propagation and separation. Several spiral geometries with different cross-sections were tested using computational fluid dynamics (CFD) to separate two particle types representing RBCs and WBCs. The chosen three geometries consist of a single inlet, two outlets, and three spiral turns, each having a different cross-sectional height (120, 135, and 150 µm). Particle separation was successfully achieved in the 135 µm-height microchannel, while other microchannels demonstrated mixed particle types at the outlets.
dc.language	en
dc.publisher	MDPI
dc.relation.ispartof	Fluids
dc.relation.isbasedon	10.3390/fluids7090308
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Computational Inertial Microfluidics: Optimal Design for Particle Separation
dc.type	Journal Article
utslib.citation.volume	7
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2023-03-12T21:40:24Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	7
utslib.citation.issue	9

Abstract:

Following the emergence of many blood transfusion-associated diseases, novel passive cell separation technologies, such as microfluidic devices, are increasingly designed and optimized to separate red blood cells (RBCs) and white blood cells (WBCs) from whole blood. These systems allow for the rapid diagnosis of diseases without relying on complicated and expensive hematology instruments such as flow microscopes, coagulation analyzers, and cytometers. The inertia effect and the impact of intrinsic hydrodynamic forces, the Dean drag force (FD), and the inertial lift force (FL) on the migration of particles within curved and complex confined channels have been explored theoretically, computationally, and experimentally. This study aimed to optimize the dimensions of a microfluidic channel for fast particle propagation and separation. Several spiral geometries with different cross-sections were tested using computational fluid dynamics (CFD) to separate two particle types representing RBCs and WBCs. The chosen three geometries consist of a single inlet, two outlets, and three spiral turns, each having a different cross-sectional height (120, 135, and 150 µm). Particle separation was successfully achieved in the 135 µm-height microchannel, while other microchannels demonstrated mixed particle types at the outlets.

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http://hdl.handle.net/10453/167068