Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends.

Nazari, H; Heirani-Tabasi, A; Ghorbani, S; Eyni, H; Razavi Bazaz, S; Khayati, M; Gheidari, F; Moradpour, K; Kehtari, M; Ahmadi Tafti, SM; Ahmadi Tafti, SH; Ebrahimi Warkiani, M

Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends.

Nazari, H Heirani-Tabasi, A Ghorbani, S Eyni, H Razavi Bazaz, S

Khayati, M Gheidari, F Moradpour, K Kehtari, M Ahmadi Tafti, SM Ahmadi Tafti, SH Ebrahimi Warkiani, M

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Biosensors (Basel), 2022, 12, (1), pp. 20
Issue Date:: 2022-01-01

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Field	Value	Language
dc.contributor.author	Nazari, H
dc.contributor.author	Heirani-Tabasi, A
dc.contributor.author	Ghorbani, S
dc.contributor.author	Eyni, H
dc.contributor.author	Razavi Bazaz, S https://orcid.org/0000-0002-6419-3361
dc.contributor.author	Khayati, M
dc.contributor.author	Gheidari, F
dc.contributor.author	Moradpour, K
dc.contributor.author	Kehtari, M
dc.contributor.author	Ahmadi Tafti, SM
dc.contributor.author	Ahmadi Tafti, SH
dc.contributor.author	Ebrahimi Warkiani, M https://orcid.org/0000-0002-4184-1944
dc.date.accessioned	2023-03-12T22:43:30Z
dc.date.available	2021-12-29
dc.date.available	2023-03-12T22:43:30Z
dc.date.issued	2022-01-01
dc.identifier.citation	Biosensors (Basel), 2022, 12, (1), pp. 20
dc.identifier.issn	2079-6374
dc.identifier.issn	2079-6374
dc.identifier.uri	http://hdl.handle.net/10453/167077
dc.description.abstract	Microfluidics is a promising approach for the facile and large-scale fabrication of monodispersed droplets for various applications in biomedicine. This technology has demonstrated great potential to address the limitations of regenerative medicine. Microfluidics provides safe, accurate, reliable, and cost-effective methods for encapsulating different stem cells, gametes, biomaterials, biomolecules, reagents, genes, and nanoparticles inside picoliter-sized droplets or droplet-derived microgels for different applications. Moreover, microenvironments made using such droplets can mimic niches of stem cells for cell therapy purposes, simulate native extracellular matrix (ECM) for tissue engineering applications, and remove challenges in cell encapsulation and three-dimensional (3D) culture methods. The fabrication of droplets using microfluidics also provides controllable microenvironments for manipulating gametes, fertilization, and embryo cultures for reproductive medicine. This review focuses on the relevant studies, and the latest progress in applying droplets in stem cell therapy, tissue engineering, reproductive biology, and gene therapy are separately evaluated. In the end, we discuss the challenges ahead in the field of microfluidics-based droplets for advanced regenerative medicine.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation	http://purl.org/au-research/grants/arc/DP170103704
dc.relation	http://purl.org/au-research/grants/arc/DP180103003
dc.relation	http://purl.org/au-research/grants/nhmrc/1143377
dc.relation.ispartof	Biosensors (Basel)
dc.relation.isbasedon	10.3390/bios12010020
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0301 Analytical Chemistry, 0601 Biochemistry and Cell Biology
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Microfluidics
dc.subject.mesh	Regenerative Medicine
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Microfluidics
dc.subject.mesh	Regenerative Medicine
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Microfluidics
dc.subject.mesh	Regenerative Medicine
dc.subject.mesh	Tissue Engineering
dc.title	Microfluidic-Based Droplets for Advanced Regenerative Medicine: Current Challenges and Future Trends.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	Switzerland
utslib.for	0301 Analytical Chemistry
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2023-03-12T22:43:25Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	12
utslib.citation.issue	1

Abstract:

Microfluidics is a promising approach for the facile and large-scale fabrication of monodispersed droplets for various applications in biomedicine. This technology has demonstrated great potential to address the limitations of regenerative medicine. Microfluidics provides safe, accurate, reliable, and cost-effective methods for encapsulating different stem cells, gametes, biomaterials, biomolecules, reagents, genes, and nanoparticles inside picoliter-sized droplets or droplet-derived microgels for different applications. Moreover, microenvironments made using such droplets can mimic niches of stem cells for cell therapy purposes, simulate native extracellular matrix (ECM) for tissue engineering applications, and remove challenges in cell encapsulation and three-dimensional (3D) culture methods. The fabrication of droplets using microfluidics also provides controllable microenvironments for manipulating gametes, fertilization, and embryo cultures for reproductive medicine. This review focuses on the relevant studies, and the latest progress in applying droplets in stem cell therapy, tissue engineering, reproductive biology, and gene therapy are separately evaluated. In the end, we discuss the challenges ahead in the field of microfluidics-based droplets for advanced regenerative medicine.

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http://hdl.handle.net/10453/167077