3D Printing for Microfluidics

Publication Type:
Thesis
Issue Date:
2022
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Microfluidics is a science that allows the manipulation of minuscule fluid samples, ordinarily in the range of microliters, within networks of channels ranging from tens to hundreds of micrometers. Microfluidics has enormous features, including reduced reagent consumption, deeper analysis, higher sensitivity, rapid processing, detailed spatial resolution, process integration, and automation. However, the fabrication of these devices has been considered an ongoing challenging issue for this community. Although photolithography has considered the gold standard for fabricating microfluidic devices, it requires time-consuming sets of principles and adroit users. More importantly, for designing a new microchannel and re-iteration, all fabrication steps need to be repeated from the beginning, implying a huge gap between brainstorming and experimental testing. Furthermore, the easy and rapid fabrication of microfluidic devices is an ideal scenario for biologists, while it is unnecessary for them to learn the tedious fabrication process. As such, the current time-consuming, multi-step fabrication process of microfluidic devices impedes rapid development and innovation in microfluidic areas. In recent years, additive manufacturing, in particular, 3D printing, has gained significant traction, being named the third industrial revolution. Due to the expanding use of microfluidic systems in laboratories, 3D printing has emerged as an alternative method to the traditional, costly fabrication process. The ability to fabricate structures ranging from a few microns to several centimeters is a complex process that can only be accomplished by taking advantage of 3D printing methods. Rapid prototyping provides an opportunity to adopt a “fail fast and often” strategy, motivating researchers to utilize 3D printers in the field of microfluidics. In this thesis, I will optimize the use of 3D printing for microfluidics for a wide variety of applications.
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