Unique microstructural design of ceramic scaffolds for bone regeneration under load.

Roohani-Esfahani, SI; Dunstan, CR; Li, JJ; Lu, Z; Davies, B; Pearce, S; Field, J; Williams, R; Zreiqat, H

Unique microstructural design of ceramic scaffolds for bone regeneration under load.

Roohani-Esfahani, SI Dunstan, CR Li, JJ Lu, Z Davies, B Pearce, S Field, J Williams, R Zreiqat, H

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Publisher:: ELSEVIER SCI LTD
Publication Type:: Journal Article
Citation:: Acta Biomater, 2013, 9, (6), pp. 7014-7024
Issue Date:: 2013-06

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Field	Value	Language
dc.contributor.author	Roohani-Esfahani, SI
dc.contributor.author	Dunstan, CR
dc.contributor.author	Li, JJ
dc.contributor.author	Lu, Z
dc.contributor.author	Davies, B
dc.contributor.author	Pearce, S
dc.contributor.author	Field, J
dc.contributor.author	Williams, R
dc.contributor.author	Zreiqat, H
dc.date.accessioned	2023-03-27T06:21:41Z
dc.date.available	2013-02-22
dc.date.available	2023-03-27T06:21:41Z
dc.date.issued	2013-06
dc.identifier.citation	Acta Biomater, 2013, 9, (6), pp. 7014-7024
dc.identifier.issn	1742-7061
dc.identifier.issn	1878-7568
dc.identifier.uri	http://hdl.handle.net/10453/168607
dc.description.abstract	During the past two decades, research on ceramic scaffolds for bone regeneration has progressed rapidly; however, currently available porous scaffolds remain unsuitable for load-bearing applications. The key to success is to apply microstructural design strategies to develop ceramic scaffolds with mechanical properties approaching those of bone. Here we report on the development of a unique microstructurally designed ceramic scaffold, strontium-hardystonite-gahnite (Sr-HT-gahnite), with 85% porosity, 500μm pore size, a competitive compressive strength of 4.1±0.3MPa and a compressive modulus of 170±20MPa. The in vitro biocompatibility of the scaffolds was studied using primary human bone-derived cells. The ability of Sr-HT-gahnite scaffolds to repair critical-sized bone defects was also investigated in a rabbit radius under normal load, with β-tricalcium phosphate/hydroxyapatite scaffolds used in the control group. Studies with primary human osteoblast cultures confirmed the bioactivity of these scaffolds, and regeneration of rabbit radial critical defects demonstrated that this material induces new bone defect bridging, with clear evidence of regeneration of original radial architecture and bone marrow environment.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCI LTD
dc.relation.ispartof	Acta Biomater
dc.relation.isbasedon	10.1016/j.actbio.2013.02.039
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Biomedical Engineering
dc.subject.mesh	Animals
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Equipment Design
dc.subject.mesh	Equipment Failure Analysis
dc.subject.mesh	Fracture Healing
dc.subject.mesh	Guided Tissue Regeneration
dc.subject.mesh	Male
dc.subject.mesh	Materials Testing
dc.subject.mesh	Rabbits
dc.subject.mesh	Radius Fractures
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Animals
dc.subject.mesh	Rabbits
dc.subject.mesh	Radius Fractures
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Guided Tissue Regeneration
dc.subject.mesh	Equipment Design
dc.subject.mesh	Equipment Failure Analysis
dc.subject.mesh	Materials Testing
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Fracture Healing
dc.subject.mesh	Male
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Animals
dc.subject.mesh	Bone Regeneration
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Ceramics
dc.subject.mesh	Equipment Design
dc.subject.mesh	Equipment Failure Analysis
dc.subject.mesh	Fracture Healing
dc.subject.mesh	Guided Tissue Regeneration
dc.subject.mesh	Male
dc.subject.mesh	Materials Testing
dc.subject.mesh	Rabbits
dc.subject.mesh	Radius Fractures
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Treatment Outcome
dc.title	Unique microstructural design of ceramic scaffolds for bone regeneration under load.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2023-03-27T06:21:38Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	6

Abstract:

During the past two decades, research on ceramic scaffolds for bone regeneration has progressed rapidly; however, currently available porous scaffolds remain unsuitable for load-bearing applications. The key to success is to apply microstructural design strategies to develop ceramic scaffolds with mechanical properties approaching those of bone. Here we report on the development of a unique microstructurally designed ceramic scaffold, strontium-hardystonite-gahnite (Sr-HT-gahnite), with 85% porosity, 500μm pore size, a competitive compressive strength of 4.1±0.3MPa and a compressive modulus of 170±20MPa. The in vitro biocompatibility of the scaffolds was studied using primary human bone-derived cells. The ability of Sr-HT-gahnite scaffolds to repair critical-sized bone defects was also investigated in a rabbit radius under normal load, with β-tricalcium phosphate/hydroxyapatite scaffolds used in the control group. Studies with primary human osteoblast cultures confirmed the bioactivity of these scaffolds, and regeneration of rabbit radial critical defects demonstrated that this material induces new bone defect bridging, with clear evidence of regeneration of original radial architecture and bone marrow environment.

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http://hdl.handle.net/10453/168607