miRNA interplay: mechanisms and consequences in cancer

Hill, M; Tran, N

miRNA interplay: mechanisms and consequences in cancer

Hill, M

Tran, N

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Publisher:: Company of Biologists
Publication Type:: Journal Article
Citation:: Disease Models and Mechanisms, 2021, 14, (4), pp. 1-9
Issue Date:: 2021-04-01

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Field	Value	Language
dc.contributor.author	Hill, M https://orcid.org/0000-0003-4637-1483
dc.contributor.author	Tran, N https://orcid.org/0000-0001-7747-2530
dc.date.accessioned	2023-03-27T23:12:05Z
dc.date.available	2023-03-27T23:12:05Z
dc.date.issued	2021-04-01
dc.identifier.citation	Disease Models and Mechanisms, 2021, 14, (4), pp. 1-9
dc.identifier.issn	1754-8403
dc.identifier.issn	1754-8411
dc.identifier.uri	http://hdl.handle.net/10453/168637
dc.description.abstract	Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown that miRNAs are also capable of targeting non-coding RNAs, including long non-coding RNAs and miRNAs. The latter, termed a miRNA:miRNA interaction, is a form of self-regulation. In this Review, we discuss the three main modes of miRNA:miRNA regulation: direct, indirect and global interactions, and their implications in cancer biology. We also discuss the cell-type-specific nature of miRNA:miRNA interactions, current experimental approaches and bioinformatic techniques, and how these strategies are not sufficient for the identification of novel miRNA:miRNA interactions. The self-regulation of miRNAs and their impact on gene regulation has yet to be fully understood. Investigating this hidden world of miRNA self-regulation will assist in discovering novel regulatory mechanisms associated with disease pathways
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Company of Biologists
dc.relation.ispartof	Disease Models and Mechanisms
dc.relation.isbasedon	10.1242/dmm.047662
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	06 Biological Sciences, 11 Medical and Health Sciences
dc.subject.classification	Developmental Biology
dc.subject.mesh	Animals
dc.subject.mesh	Gene Expression Regulation, Neoplastic
dc.subject.mesh	Humans
dc.subject.mesh	MicroRNAs
dc.subject.mesh	Models, Biological
dc.subject.mesh	Neoplasms
dc.subject.mesh	Transcription Factors
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Transcription Factors
dc.subject.mesh	MicroRNAs
dc.subject.mesh	Gene Expression Regulation, Neoplastic
dc.subject.mesh	Models, Biological
dc.subject.mesh	Animals
dc.subject.mesh	Gene Expression Regulation, Neoplastic
dc.subject.mesh	Humans
dc.subject.mesh	MicroRNAs
dc.subject.mesh	Models, Biological
dc.subject.mesh	Neoplasms
dc.subject.mesh	Transcription Factors
dc.title	miRNA interplay: mechanisms and consequences in cancer
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	England
utslib.for	06 Biological Sciences
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2023-03-27T23:12:04Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	14
utslib.citation.issue	4

Abstract:

Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown that miRNAs are also capable of targeting non-coding RNAs, including long non-coding RNAs and miRNAs. The latter, termed a miRNA:miRNA interaction, is a form of self-regulation. In this Review, we discuss the three main modes of miRNA:miRNA regulation: direct, indirect and global interactions, and their implications in cancer biology. We also discuss the cell-type-specific nature of miRNA:miRNA interactions, current experimental approaches and bioinformatic techniques, and how these strategies are not sufficient for the identification of novel miRNA:miRNA interactions. The self-regulation of miRNAs and their impact on gene regulation has yet to be fully understood. Investigating this hidden world of miRNA self-regulation will assist in discovering novel regulatory mechanisms associated with disease pathways

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http://hdl.handle.net/10453/168637