Methods for Silk Property Analyses across Structural Hierarchies and Scales.

Blamires, SJ; Rawal, A; Edwards, AD; Yarger, JL; Oberst, S; Allardyce, BJ; Rajkhowa, R

Methods for Silk Property Analyses across Structural Hierarchies and Scales.

Blamires, SJ Rawal, A Edwards, AD Yarger, JL Oberst, S

Allardyce, BJ Rajkhowa, R

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Molecules, 2023, 28, (5), pp. 2120
Issue Date:: 2023-02-24

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Field	Value	Language
dc.contributor.author	Blamires, SJ
dc.contributor.author	Rawal, A
dc.contributor.author	Edwards, AD
dc.contributor.author	Yarger, JL
dc.contributor.author	Oberst, S https://orcid.org/0000-0002-1388-2749
dc.contributor.author	Allardyce, BJ
dc.contributor.author	Rajkhowa, R
dc.date.accessioned	2023-03-30T05:29:54Z
dc.date.available	2023-02-20
dc.date.available	2023-03-30T05:29:54Z
dc.date.issued	2023-02-24
dc.identifier.citation	Molecules, 2023, 28, (5), pp. 2120
dc.identifier.issn	1420-3049
dc.identifier.issn	1420-3049
dc.identifier.uri	http://hdl.handle.net/10453/168847
dc.description.abstract	Silk from silkworms and spiders is an exceptionally important natural material, inspiring a range of new products and applications due to its high strength, elasticity, and toughness at low density, as well as its unique conductive and optical properties. Transgenic and recombinant technologies offer great promise for the scaled-up production of new silkworm- and spider-silk-inspired fibres. However, despite considerable effort, producing an artificial silk that recaptures the physico-chemical properties of naturally spun silk has thus far proven elusive. The mechanical, biochemical, and other properties of pre-and post-development fibres accordingly should be determined across scales and structural hierarchies whenever feasible. We have herein reviewed and made recommendations on some of those practices for measuring the bulk fibre properties; skin-core structures; and the primary, secondary, and tertiary structures of silk proteins and the properties of dopes and their proteins. We thereupon examine emerging methodologies and make assessments on how they might be utilized to realize the goal of developing high quality bio-inspired fibres.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Molecules
dc.relation.isbasedon	10.3390/molecules28052120
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, 0307 Theoretical and Computational Chemistry
dc.subject.classification	Organic Chemistry
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Genetically Modified
dc.subject.mesh	Elasticity
dc.subject.mesh	Spiders
dc.subject.mesh	Bombyx
dc.subject.mesh	Fibroins
dc.subject.mesh	Animals
dc.subject.mesh	Animals, Genetically Modified
dc.subject.mesh	Spiders
dc.subject.mesh	Bombyx
dc.subject.mesh	Fibroins
dc.subject.mesh	Elasticity
dc.title	Methods for Silk Property Analyses across Structural Hierarchies and Scales.
dc.type	Journal Article
utslib.citation.volume	28
utslib.location.activity	Switzerland
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	0305 Organic Chemistry
utslib.for	0307 Theoretical and Computational Chemistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2023-03-30T05:29:47Z
pubs.issue	5
pubs.publication-status	Published online
pubs.volume	28
utslib.citation.issue	5

Abstract:

Silk from silkworms and spiders is an exceptionally important natural material, inspiring a range of new products and applications due to its high strength, elasticity, and toughness at low density, as well as its unique conductive and optical properties. Transgenic and recombinant technologies offer great promise for the scaled-up production of new silkworm- and spider-silk-inspired fibres. However, despite considerable effort, producing an artificial silk that recaptures the physico-chemical properties of naturally spun silk has thus far proven elusive. The mechanical, biochemical, and other properties of pre-and post-development fibres accordingly should be determined across scales and structural hierarchies whenever feasible. We have herein reviewed and made recommendations on some of those practices for measuring the bulk fibre properties; skin-core structures; and the primary, secondary, and tertiary structures of silk proteins and the properties of dopes and their proteins. We thereupon examine emerging methodologies and make assessments on how they might be utilized to realize the goal of developing high quality bio-inspired fibres.

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http://hdl.handle.net/10453/168847