Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications.
Radfar, P
Aboulkheyr Es, H
Salomon, R
Kulasinghe, A
Ramalingam, N
Sarafraz-Yazdi, E
Thiery, JP
Warkiani, ME
- Publisher:
- ELSEVIER SCIENCE LONDON
- Publication Type:
- Journal Article
- Citation:
- Trends Biotechnol, 2022, 40, (9), pp. 1041-1060
- Issue Date:
- 2022-09
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Radfar, P | |
dc.contributor.author | Aboulkheyr Es, H | |
dc.contributor.author |
Salomon, R https://orcid.org/0000-0003-4504-2901 |
|
dc.contributor.author | Kulasinghe, A | |
dc.contributor.author | Ramalingam, N | |
dc.contributor.author | Sarafraz-Yazdi, E | |
dc.contributor.author | Thiery, JP | |
dc.contributor.author | Warkiani, ME | |
dc.date.accessioned | 2023-04-03T04:09:29Z | |
dc.date.available | 2022-02-16 | |
dc.date.available | 2023-04-03T04:09:29Z | |
dc.date.issued | 2022-09 | |
dc.identifier.citation | Trends Biotechnol, 2022, 40, (9), pp. 1041-1060 | |
dc.identifier.issn | 0167-7799 | |
dc.identifier.issn | 1879-3096 | |
dc.identifier.uri | http://hdl.handle.net/10453/169069 | |
dc.description.abstract | Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide remarkable insight for cancer development and metastasis. CTCs and CTC clusters investigation using single-cell analysis, enables researchers to gain crucial information on metastatic mechanisms and the genomic alterations responsible for drug resistance, empowering treatment, and management of cancer. Despite a plethora of CTC isolation technologies, careful attention to the strengths and weaknesses of each method should be considered in order to isolate these rare cells. Here, we provide an overview of cutting-edge technologies used for single-cell isolation and analysis of CTCs. Additionally, we highlight the biological features, clinical application, and the therapeutic potential of CTCs and CTC clusters using single-cell analysis platforms for cancer management. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | ELSEVIER SCIENCE LONDON | |
dc.relation | http://purl.org/au-research/grants/arc/DP200101860 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/GNT1143377 | |
dc.relation.ispartof | Trends Biotechnol | |
dc.relation.isbasedon | 10.1016/j.tibtech.2022.02.004 | |
dc.rights | info:eu-repo/semantics/embargoedAccess | |
dc.subject | 06 Biological Sciences, 09 Engineering, 10 Technology | |
dc.subject.classification | Biotechnology | |
dc.subject.mesh | Cell Separation | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Neoplastic Cells, Circulating | |
dc.subject.mesh | Single-Cell Analysis | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Cell Separation | |
dc.subject.mesh | Neoplastic Cells, Circulating | |
dc.subject.mesh | Single-Cell Analysis | |
dc.subject.mesh | Cell Separation | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Neoplastic Cells, Circulating | |
dc.subject.mesh | Single-Cell Analysis | |
dc.title | Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications. | |
dc.type | Journal Article | |
utslib.citation.volume | 40 | |
utslib.location.activity | England | |
utslib.for | 06 Biological Sciences | |
utslib.for | 09 Engineering | |
utslib.for | 10 Technology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | open_access | * |
utslib.copyright.embargo | 2023-09-01T00:00:00+1000Z | |
dc.date.updated | 2023-04-03T04:09:27Z | |
pubs.issue | 9 | |
pubs.publication-status | Published | |
pubs.volume | 40 | |
utslib.citation.issue | 9 |
Abstract:
Multimodal analysis of circulating tumour cells (CTCs) has the potential to provide remarkable insight for cancer development and metastasis. CTCs and CTC clusters investigation using single-cell analysis, enables researchers to gain crucial information on metastatic mechanisms and the genomic alterations responsible for drug resistance, empowering treatment, and management of cancer. Despite a plethora of CTC isolation technologies, careful attention to the strengths and weaknesses of each method should be considered in order to isolate these rare cells. Here, we provide an overview of cutting-edge technologies used for single-cell isolation and analysis of CTCs. Additionally, we highlight the biological features, clinical application, and the therapeutic potential of CTCs and CTC clusters using single-cell analysis platforms for cancer management.
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