'Skeletal Age' for mapping the impact of fracture on mortality.
- Publisher:
- eLife
- Publication Type:
- Journal Article
- Citation:
- Elife, 2023, 12, pp. e83888
- Issue Date:
- 2023-05-16
Open Access
Copyright Clearance Process
- Recently Added
- In Progress
- Open Access
This item is open access.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tran, T | |
dc.contributor.author | Ho-Le, T | |
dc.contributor.author | Bliuc, D | |
dc.contributor.author | Abrahamsen, B | |
dc.contributor.author | Hansen, L | |
dc.contributor.author | Vestergaard, P | |
dc.contributor.author | Center, JR | |
dc.contributor.author | Nguyen, TV | |
dc.date.accessioned | 2023-08-02T02:11:50Z | |
dc.date.available | 2023-03-31 | |
dc.date.available | 2023-08-02T02:11:50Z | |
dc.date.issued | 2023-05-16 | |
dc.identifier.citation | Elife, 2023, 12, pp. e83888 | |
dc.identifier.issn | 2050-084X | |
dc.identifier.issn | 2050-084X | |
dc.identifier.uri | http://hdl.handle.net/10453/171698 | |
dc.description.abstract | BACKGROUND: Fragility fracture is associated with an increased risk of mortality, but mortality is not part of doctor-patient communication. Here, we introduce a new concept called 'Skeletal Age' as the age of an individual's skeleton resulting from a fragility fracture to convey the combined risk of fracture and fracture-associated mortality for an individual. METHODS: We used the Danish National Hospital Discharge Register which includes the whole-country data of 1,667,339 adults in Denmark born on or before January 1, 1950, who were followed up to December 31, 2016 for incident low-trauma fracture and mortality. Skeletal age is defined as the sum of chronological age and the number of years of life lost (YLL) associated with a fracture. Cox's proportional hazards model was employed to determine the hazard of mortality associated with a specific fracture for a given risk profile, and the hazard was then transformed into YLL using the Gompertz law of mortality. RESULTS: During the median follow-up period of 16 years, there had been 307,870 fractures and 122,744 post-fracture deaths. A fracture was associated with between 1 and 7 years of life lost, with the loss being greater in men than women. Hip fractures incurred the greatest loss of life years. For instance, a 60-year-old individual with a hip fracture is estimated to have a skeletal age of 66 for men and 65 for women. Skeletal Age was estimated for each age and fracture site stratified by gender. CONCLUSIONS: We propose 'Skeletal Age' as a new metric to assess the impact of a fragility fracture on an individual's life expectancy. This approach will enhance doctor-patient risk communication about the risks associated with osteoporosis. FUNDING: National Health and Medical Research Council in Australia and Amgen Competitive Grant Program 2019. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | eLife | |
dc.relation | http://purl.org/au-research/grants/nhmrc/GNT1195305 | |
dc.relation.ispartof | Elife | |
dc.relation.isbasedon | 10.7554/eLife.83888 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | 0601 Biochemistry and Cell Biology | |
dc.subject.classification | 31 Biological sciences | |
dc.subject.classification | 32 Biomedical and clinical sciences | |
dc.subject.classification | 42 Health sciences | |
dc.subject.mesh | Male | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Female | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Osteoporosis | |
dc.subject.mesh | Osteoporotic Fractures | |
dc.subject.mesh | Life Expectancy | |
dc.subject.mesh | Proportional Hazards Models | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Osteoporosis | |
dc.subject.mesh | Life Expectancy | |
dc.subject.mesh | Proportional Hazards Models | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Australia | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Osteoporotic Fractures | |
dc.subject.mesh | Male | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Female | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Osteoporosis | |
dc.subject.mesh | Osteoporotic Fractures | |
dc.subject.mesh | Life Expectancy | |
dc.subject.mesh | Proportional Hazards Models | |
dc.subject.mesh | Australia | |
dc.title | 'Skeletal Age' for mapping the impact of fracture on mortality. | |
dc.type | Journal Article | |
utslib.citation.volume | 12 | |
utslib.location.activity | England | |
utslib.for | 0601 Biochemistry and Cell Biology | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2023-08-02T02:11:47Z | |
pubs.publication-status | Published online | |
pubs.volume | 12 |
Abstract:
BACKGROUND: Fragility fracture is associated with an increased risk of mortality, but mortality is not part of doctor-patient communication. Here, we introduce a new concept called 'Skeletal Age' as the age of an individual's skeleton resulting from a fragility fracture to convey the combined risk of fracture and fracture-associated mortality for an individual. METHODS: We used the Danish National Hospital Discharge Register which includes the whole-country data of 1,667,339 adults in Denmark born on or before January 1, 1950, who were followed up to December 31, 2016 for incident low-trauma fracture and mortality. Skeletal age is defined as the sum of chronological age and the number of years of life lost (YLL) associated with a fracture. Cox's proportional hazards model was employed to determine the hazard of mortality associated with a specific fracture for a given risk profile, and the hazard was then transformed into YLL using the Gompertz law of mortality. RESULTS: During the median follow-up period of 16 years, there had been 307,870 fractures and 122,744 post-fracture deaths. A fracture was associated with between 1 and 7 years of life lost, with the loss being greater in men than women. Hip fractures incurred the greatest loss of life years. For instance, a 60-year-old individual with a hip fracture is estimated to have a skeletal age of 66 for men and 65 for women. Skeletal Age was estimated for each age and fracture site stratified by gender. CONCLUSIONS: We propose 'Skeletal Age' as a new metric to assess the impact of a fragility fracture on an individual's life expectancy. This approach will enhance doctor-patient risk communication about the risks associated with osteoporosis. FUNDING: National Health and Medical Research Council in Australia and Amgen Competitive Grant Program 2019.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph