Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.

Kapellos, TS; Baßler, K; Fujii, W; Nalkurthi, C; Schaar, AC; Bonaguro, L; Pecht, T; Galvao, I; Agrawal, S; Saglam, A; Dudkin, E; Frishberg, A; de Domenico, E; Horne, A; Donovan, C; Kim, RY; Gallego-Ortega, D; Gillett, TE; Ansari, M; Schulte-Schrepping, J; Offermann, N; Antignano, I; Sivri, B; Lu, W; Eapen, MS; van Uelft, M; Osei-Sarpong, C; van den Berge, M; Donker, HC; Groen, HJM; Sohal, SS; Klein, J; Schreiber, T; Feißt, A; Yildirim, AÖ; Schiller, HB; Nawijn, MC; Becker, M; Händler, K; Beyer, M; Capasso, M; Ulas, T; Hasenauer, J; Pizarro, C; Theis, FJ; Hansbro, PM; Skowasch, D; Schultze, JL

Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.

Kapellos, TS Baßler, K Fujii, W Nalkurthi, C Schaar, AC Bonaguro, L Pecht, T Galvao, I Agrawal, S Saglam, A Dudkin, E Frishberg, A de Domenico, E Horne, A Donovan, C

Kim, RY Gallego-Ortega, D Gillett, TE Ansari, M Schulte-Schrepping, J Offermann, N Antignano, I Sivri, B Lu, W Eapen, MS van Uelft, M Osei-Sarpong, C van den Berge, M Donker, HC Groen, HJM Sohal, SS Klein, J Schreiber, T Feißt, A Yildirim, AÖ Schiller, HB Nawijn, MC Becker, M Händler, K Beyer, M Capasso, M Ulas, T Hasenauer, J Pizarro, C Theis, FJ Hansbro, PM Skowasch, D Schultze, JL

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Cell Rep, 2023, 42, (6), pp. 112525
Issue Date:: 2023-05-25

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Field	Value	Language
dc.contributor.author	Kapellos, TS
dc.contributor.author	Baßler, K
dc.contributor.author	Fujii, W
dc.contributor.author	Nalkurthi, C
dc.contributor.author	Schaar, AC
dc.contributor.author	Bonaguro, L
dc.contributor.author	Pecht, T
dc.contributor.author	Galvao, I
dc.contributor.author	Agrawal, S
dc.contributor.author	Saglam, A
dc.contributor.author	Dudkin, E
dc.contributor.author	Frishberg, A
dc.contributor.author	de Domenico, E
dc.contributor.author	Horne, A
dc.contributor.author	Donovan, C https://orcid.org/0000-0003-4558-329X
dc.contributor.author	Kim, RY
dc.contributor.author	Gallego-Ortega, D
dc.contributor.author	Gillett, TE
dc.contributor.author	Ansari, M
dc.contributor.author	Schulte-Schrepping, J
dc.contributor.author	Offermann, N
dc.contributor.author	Antignano, I
dc.contributor.author	Sivri, B
dc.contributor.author	Lu, W
dc.contributor.author	Eapen, MS
dc.contributor.author	van Uelft, M
dc.contributor.author	Osei-Sarpong, C
dc.contributor.author	van den Berge, M
dc.contributor.author	Donker, HC
dc.contributor.author	Groen, HJM
dc.contributor.author	Sohal, SS
dc.contributor.author	Klein, J
dc.contributor.author	Schreiber, T
dc.contributor.author	Feißt, A
dc.contributor.author	Yildirim, AÖ
dc.contributor.author	Schiller, HB
dc.contributor.author	Nawijn, MC
dc.contributor.author	Becker, M
dc.contributor.author	Händler, K
dc.contributor.author	Beyer, M
dc.contributor.author	Capasso, M
dc.contributor.author	Ulas, T
dc.contributor.author	Hasenauer, J
dc.contributor.author	Pizarro, C
dc.contributor.author	Theis, FJ
dc.contributor.author	Hansbro, PM
dc.contributor.author	Skowasch, D
dc.contributor.author	Schultze, JL
dc.date.accessioned	2023-08-09T05:30:20Z
dc.date.available	2023-05-01
dc.date.available	2023-08-09T05:30:20Z
dc.date.issued	2023-05-25
dc.identifier.citation	Cell Rep, 2023, 42, (6), pp. 112525
dc.identifier.issn	2211-1247
dc.identifier.issn	2211-1247
dc.identifier.uri	http://hdl.handle.net/10453/171766
dc.description.abstract	Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation	http://purl.org/au-research/grants/nhmrc/1175134
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1175134
dc.relation.ispartof	Cell Rep
dc.relation.isbasedon	10.1016/j.celrep.2023.112525
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 1116 Medical Physiology
dc.subject.classification	31 Biological sciences
dc.title	Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.
dc.type	Journal Article
utslib.citation.volume	42
utslib.location.activity	United States
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	open_access	*
dc.date.updated	2023-08-09T05:30:19Z
pubs.issue	6
pubs.publication-status	Published online
pubs.volume	42
utslib.citation.issue	6

Abstract:

Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/171766