Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs

Chan, M; Ghadieh, C; Irfan, I; Khair, E; Padilla, N; Rebeiro, S; Sidgreaves, A; Patravale, V; Disouza, J; Catanzariti, R; Pont, L; Williams, K; De Rubis, G; Mehndiratta, S; Dhanasekaran, M; Dua, K

Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs

Chan, M Ghadieh, C Irfan, I Khair, E Padilla, N Rebeiro, S Sidgreaves, A Patravale, V Disouza, J Catanzariti, R Pont, L Williams, K De Rubis, G Mehndiratta, S Dhanasekaran, M Dua, K

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Publisher:: Springer Science and Business Media LLC
Publication Type:: Journal Article
Citation:: Naunyn-Schmiedeberg's Archives of Pharmacology

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Field	Value	Language
dc.contributor.author	Chan, M
dc.contributor.author	Ghadieh, C
dc.contributor.author	Irfan, I
dc.contributor.author	Khair, E
dc.contributor.author	Padilla, N
dc.contributor.author	Rebeiro, S
dc.contributor.author	Sidgreaves, A
dc.contributor.author	Patravale, V
dc.contributor.author	Disouza, J
dc.contributor.author	Catanzariti, R
dc.contributor.author	Pont, L
dc.contributor.author	Williams, K
dc.contributor.author	De Rubis, G
dc.contributor.author	Mehndiratta, S
dc.contributor.author	Dhanasekaran, M
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2023-09-01T10:42:05Z
dc.date.available	2023-09-01T10:42:05Z
dc.identifier.citation	Naunyn-Schmiedeberg's Archives of Pharmacology
dc.identifier.issn	0028-1298
dc.identifier.issn	1432-1912
dc.identifier.uri	http://hdl.handle.net/10453/171882
dc.description.abstract	<jats:title>Abstract</jats:title><jats:p>The microbiome is increasingly implicated in playing a role in physiology and pharmacology; in this review, we investigate the literature on the possibility of bacterial influence on the pharmacology of anti-asthmatic drugs, and the potential impact this has on asthmatic patients. Current knowledge in this area of research reveals an interaction between the gut and lung microbiome and the development of asthma. The influence of microbiome on the pharmacokinetics and pharmacodynamics of anti-asthmatic drugs is limited; however, understanding this interaction will assist in creating a more efficient treatment approach. This literature review highlighted that bioaccumulation and biotransformation in the presence of certain gut bacterial strains could affect drug metabolism in anti-asthmatic drugs. Furthermore, the bacterial richness in the lungs and the gut can influence drug efficacy and could also play a role in drug response. The implications of the above findings suggest that the microbiome is a contributing factor to an individuals’ pharmacological response to anti-asthmatic drugs. Hence, future directions for research should follow investigating how these processes affect asthmatic patients and consider the role of the microbiome on drug efficacy and modify treatment guidelines accordingly.</jats:p>
dc.language	en
dc.publisher	Springer Science and Business Media LLC
dc.relation.ispartof	Naunyn-Schmiedeberg's Archives of Pharmacology
dc.relation.isbasedon	10.1007/s00210-023-02681-5
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences, 1116 Medical Physiology
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs
dc.type	Journal Article
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2023-09-01T10:42:04Z
pubs.publication-status	Published online

Abstract:

AbstractThe microbiome is increasingly implicated in playing a role in physiology and pharmacology; in this review, we investigate the literature on the possibility of bacterial influence on the pharmacology of anti-asthmatic drugs, and the potential impact this has on asthmatic patients. Current knowledge in this area of research reveals an interaction between the gut and lung microbiome and the development of asthma. The influence of microbiome on the pharmacokinetics and pharmacodynamics of anti-asthmatic drugs is limited; however, understanding this interaction will assist in creating a more efficient treatment approach. This literature review highlighted that bioaccumulation and biotransformation in the presence of certain gut bacterial strains could affect drug metabolism in anti-asthmatic drugs. Furthermore, the bacterial richness in the lungs and the gut can influence drug efficacy and could also play a role in drug response. The implications of the above findings suggest that the microbiome is a contributing factor to an individuals’ pharmacological response to anti-asthmatic drugs. Hence, future directions for research should follow investigating how these processes affect asthmatic patients and consider the role of the microbiome on drug efficacy and modify treatment guidelines accordingly.

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http://hdl.handle.net/10453/171882