3D Bioprinting for Cardiovascular Applications

Matthews, N; Ly, S; West, D; Gentile, C

3D Bioprinting for Cardiovascular Applications

Matthews, N Ly, S West, D Gentile, C

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Publisher:: CRC Press
Publication Type:: Chapter
Citation:: 3D Bioprinting for Cardiovascular Applications, 2023, 1st, pp. 169-190
Issue Date:: 2023-09-27

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Field	Value	Language
dc.contributor.author	Matthews, N
dc.contributor.author	Ly, S
dc.contributor.author	West, D
dc.contributor.author	Gentile, C
dc.contributor.editor	Muñoz, JLP
dc.contributor.editor	Martínez, LSDB
dc.contributor.editor	Ochoa, GP
dc.contributor.editor	Sesma, JZ
dc.date.accessioned	2023-09-04T00:15:52Z
dc.date.available	2023-09-04T00:15:52Z
dc.date.issued	2023-09-27
dc.identifier.citation	3D Bioprinting for Cardiovascular Applications, 2023, 1st, pp. 169-190
dc.identifier.isbn	9781003274568
dc.identifier.uri	http://hdl.handle.net/10453/171884
dc.description.abstract	A heart transplant is considered the gold standard treatment for end-stage heart failure patients, however the operation is reliant on organ donors and poses several clinical and economical risk factors. Tissue engineering has shown promise in providing a future alternative for organ transplants. The potential for mimicking native healthy tissue has been brought closer to realisation with 3D bioprinting. The method allows for precise deposition of cellular material into biomaterials suitable for transplantation. By culturing the cellular material using patient stem cells, the 3D bioprinted transplant can be personalised for each patient. This book chapter presents the current state of 3D bioprinting applied in developing personalised cardiac patches. An overview of cardiac anatomy and the impact of myocardial infarction is followed by a comparison of 3D bioprinting methods, commonly used biomaterials, and the characteristics of cells and cellular spheroids. This is followed by a review of findings from animal studies using 3D bioprinted cardiac patches to date and highlights the challenges of translating the method for clinical studies. Biological and design considerations for developing personalised cardiac patches conclude the review leading to the discussion of the chapter findings.
dc.format.extent	13
dc.language	en
dc.publisher	CRC Press
dc.relation.ispartof	3D Bioprinting for Cardiovascular Applications
dc.relation.isbasedon	10.1201/9781003274568-8
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.title	3D Bioprinting for Cardiovascular Applications
dc.type	Chapter
utslib.citation.edition	1st
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	embargoed	*
pubs.consider-herdc	true
utslib.copyright.embargo	2025-03-27T00:00:00+1000Z
dc.date.updated	2023-09-04T00:15:49Z
pubs.edition	1st
pubs.place-of-publication	Boca Raton
pubs.publication-status	Published online
dc.location	Boca Raton

Abstract:

A heart transplant is considered the gold standard treatment for end-stage heart failure patients, however the operation is reliant on organ donors and poses several clinical and economical risk factors. Tissue engineering has shown promise in providing a future alternative for organ transplants. The potential for mimicking native healthy tissue has been brought closer to realisation with 3D bioprinting. The method allows for precise deposition of cellular material into biomaterials suitable for transplantation. By culturing the cellular material using patient stem cells, the 3D bioprinted transplant can be personalised for each patient. This book chapter presents the current state of 3D bioprinting applied in developing personalised cardiac patches. An overview of cardiac anatomy and the impact of myocardial infarction is followed by a comparison of 3D bioprinting methods, commonly used biomaterials, and the characteristics of cells and cellular spheroids. This is followed by a review of findings from animal studies using 3D bioprinted cardiac patches to date and highlights the challenges of translating the method for clinical studies. Biological and design considerations for developing personalised cardiac patches conclude the review leading to the discussion of the chapter findings.

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http://hdl.handle.net/10453/171884