Evaluation of a Clinic-Based Exercise Program in Patients with Pancreatic Cancer Undergoing Nonsurgical Treatment.
Luo, H
Galvão, DA
Newton, RU
Tang, CI
Hart, NH
Singh, F
Dean, A
Jasas, K
Johansson, M
Yusoff, I
Spry, N
Taaffe, DR
- Publisher:
- Wolters Kluwer
- Publication Type:
- Journal Article
- Citation:
- Med Sci Sports Exerc, 2023, 55, (1), pp. 9-19
- Issue Date:
- 2023-01-01
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Evaluation of a Clinic-Based Exercise Program in Patients with Pancreatic Cancer Undergoing Nonsurgical Treatment.pdf | 501.65 kB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Luo, H | |
dc.contributor.author | Galvão, DA | |
dc.contributor.author | Newton, RU | |
dc.contributor.author | Tang, CI | |
dc.contributor.author | Hart, NH | |
dc.contributor.author | Singh, F | |
dc.contributor.author | Dean, A | |
dc.contributor.author | Jasas, K | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | Yusoff, I | |
dc.contributor.author | Spry, N | |
dc.contributor.author | Taaffe, DR | |
dc.date.accessioned | 2023-09-12T03:01:58Z | |
dc.date.available | 2023-09-12T03:01:58Z | |
dc.date.issued | 2023-01-01 | |
dc.identifier.citation | Med Sci Sports Exerc, 2023, 55, (1), pp. 9-19 | |
dc.identifier.issn | 0195-9131 | |
dc.identifier.issn | 1530-0315 | |
dc.identifier.uri | http://hdl.handle.net/10453/172047 | |
dc.description.abstract | INTRODUCTION: Evidence regarding the role of exercise in pancreatic cancer (PanCa) is limited and is derived exclusively under tightly controlled research conditions. This study aimed to quantify adherence, adverse events, and changes in physical and psychological outcomes in any patients with PanCa referred to undertake exercise during nonsurgical treatment. METHODS: The study involved 22 patients with localized or metastatic PanCa undertaking a clinic-based exercise program during chemotherapy or chemoradiotherapy. The program included supervised aerobic and resistance exercise undertaken twice weekly for 12 wk and a 12-wk follow-up with supervised exercise optional dependent on patient preference and condition. Patients were monitored for adherence and adverse events. Objective and patient-reported outcomes were assessed at baseline, 12 wk, and 24 wk. RESULTS: A total of 251 sessions were attended by 19 patients over the first 12 wk (attendance rate, 55%). Complete case analyses indicated significant ( P < 0.05) improvements in functional ability (5.2%-17.2%), muscle strength (16.9%-25.1%), and static balance (6.8%). There were no significant changes in body composition or patient-reported outcomes except for sleep quality, which deteriorated; however, at an individual level, several patients had clinically relevant improvements in cancer-related fatigue and quality of life. Patients who continued with supervised exercise to week 24 largely preserved improvements in functional ability, muscle strength, and static balance. No serious adverse events resulted from the exercise program. CONCLUSIONS: Individualized, supervised aerobic and resistance exercise in a clinic-based setting appears to be safe and may improve or maintain physical and psychological health in patients with PanCa undergoing nonsurgical treatment. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Wolters Kluwer | |
dc.relation.ispartof | Med Sci Sports Exerc | |
dc.relation.isbasedon | 10.1249/MSS.0000000000003019 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1106 Human Movement and Sports Sciences, 1116 Medical Physiology, 1117 Public Health and Health Services | |
dc.subject.classification | Sport Sciences | |
dc.subject.classification | 3202 Clinical sciences | |
dc.subject.classification | 3208 Medical physiology | |
dc.subject.classification | 4207 Sports science and exercise | |
dc.subject.mesh | Exercise | |
dc.subject.mesh | Exercise Therapy | |
dc.subject.mesh | Fatigue | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Pancreatic Neoplasms | |
dc.subject.mesh | Quality of Life | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Quality of Life | |
dc.subject.mesh | Exercise | |
dc.subject.mesh | Fatigue | |
dc.subject.mesh | Exercise Therapy | |
dc.subject.mesh | Pancreatic Neoplasms | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Pancreatic Neoplasms | |
dc.subject.mesh | Fatigue | |
dc.subject.mesh | Exercise | |
dc.subject.mesh | Exercise Therapy | |
dc.subject.mesh | Quality of Life | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Quality of Life | |
dc.subject.mesh | Exercise | |
dc.subject.mesh | Fatigue | |
dc.subject.mesh | Exercise Therapy | |
dc.subject.mesh | Pancreatic Neoplasms | |
dc.title | Evaluation of a Clinic-Based Exercise Program in Patients with Pancreatic Cancer Undergoing Nonsurgical Treatment. | |
dc.type | Journal Article | |
utslib.citation.volume | 55 | |
utslib.location.activity | United States | |
utslib.for | 1106 Human Movement and Sports Sciences | |
utslib.for | 1116 Medical Physiology | |
utslib.for | 1117 Public Health and Health Services | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
pubs.organisational-group | /University of Technology Sydney/Strength - HPRC - Human Performance Research Centre | |
utslib.copyright.status | closed_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2023-09-12T03:01:57Z | |
pubs.issue | 1 | |
pubs.publication-status | Published | |
pubs.volume | 55 | |
utslib.citation.issue | 1 |
Abstract:
INTRODUCTION: Evidence regarding the role of exercise in pancreatic cancer (PanCa) is limited and is derived exclusively under tightly controlled research conditions. This study aimed to quantify adherence, adverse events, and changes in physical and psychological outcomes in any patients with PanCa referred to undertake exercise during nonsurgical treatment. METHODS: The study involved 22 patients with localized or metastatic PanCa undertaking a clinic-based exercise program during chemotherapy or chemoradiotherapy. The program included supervised aerobic and resistance exercise undertaken twice weekly for 12 wk and a 12-wk follow-up with supervised exercise optional dependent on patient preference and condition. Patients were monitored for adherence and adverse events. Objective and patient-reported outcomes were assessed at baseline, 12 wk, and 24 wk. RESULTS: A total of 251 sessions were attended by 19 patients over the first 12 wk (attendance rate, 55%). Complete case analyses indicated significant ( P < 0.05) improvements in functional ability (5.2%-17.2%), muscle strength (16.9%-25.1%), and static balance (6.8%). There were no significant changes in body composition or patient-reported outcomes except for sleep quality, which deteriorated; however, at an individual level, several patients had clinically relevant improvements in cancer-related fatigue and quality of life. Patients who continued with supervised exercise to week 24 largely preserved improvements in functional ability, muscle strength, and static balance. No serious adverse events resulted from the exercise program. CONCLUSIONS: Individualized, supervised aerobic and resistance exercise in a clinic-based setting appears to be safe and may improve or maintain physical and psychological health in patients with PanCa undergoing nonsurgical treatment.
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