Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997-2022: A Systematic Review and Meta-Analysis.

Yendewa, GA; Wang, G-M; James, PB; Massaquoi, SPE; Yendewa, SA; Ghazawi, M; Babawo, LS; Ocama, P; Russell, JBW; Deen, GF; Sahr, F; Kabba, M; Tatsuoka, C; Lakoh, S; Salata, RA

Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997-2022: A Systematic Review and Meta-Analysis.

Yendewa, GA Wang, G-M James, PB Massaquoi, SPE Yendewa, SA Ghazawi, M Babawo, LS Ocama, P Russell, JBW Deen, GF Sahr, F Kabba, M Tatsuoka, C Lakoh, S Salata, RA

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Publisher:: American Society of Tropical Medicine and Hygiene
Publication Type:: Journal Article
Citation:: Am J Trop Med Hyg, 2023, 109, (1), pp. 105-114
Issue Date:: 2023-07-05

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Field	Value	Language
dc.contributor.author	Yendewa, GA
dc.contributor.author	Wang, G-M
dc.contributor.author	James, PB
dc.contributor.author	Massaquoi, SPE
dc.contributor.author	Yendewa, SA
dc.contributor.author	Ghazawi, M
dc.contributor.author	Babawo, LS
dc.contributor.author	Ocama, P
dc.contributor.author	Russell, JBW
dc.contributor.author	Deen, GF
dc.contributor.author	Sahr, F
dc.contributor.author	Kabba, M
dc.contributor.author	Tatsuoka, C
dc.contributor.author	Lakoh, S
dc.contributor.author	Salata, RA
dc.date.accessioned	2023-09-19T02:54:00Z
dc.date.available	2023-02-18
dc.date.available	2023-09-19T02:54:00Z
dc.date.issued	2023-07-05
dc.identifier.citation	Am J Trop Med Hyg, 2023, 109, (1), pp. 105-114
dc.identifier.issn	0002-9637
dc.identifier.issn	1476-1645
dc.identifier.uri	http://hdl.handle.net/10453/172198
dc.description.abstract	Hepatitis B virus (HBV) infection is a major public health problem in Sierra Leone, yet reliable estimates of cases are lacking. This study aimed to provide an estimate of the national prevalence of chronic HBV infection in the general population and select groups in Sierra Leone. We used the electronic databases PubMed/MEDLINE, Embase, Scopus, ScienceDirect, Web of Science, Google Scholar, and African Journals Online to systematically review articles reporting hepatitis B infection surface antigen seroprevalence estimates in Sierra Leone during 1997-2022. We estimated pooled HBV seroprevalence rates and assessed potential sources of heterogeneity. Of 546 publications screened, 22 studies with a total sample size of 107,186 people were included in the systematic review and meta-analysis. The pooled prevalence of chronic HBV infection was 13.0% (95% CI, 10.0-16.0) (I2 = 99%; Pheterogeneity < 0.01). During the study period, the HBV prevalence rates were as follows: 17.9% (95% CI, 6.7-39.8) before 2015, 13.3% (95% CI, 10.4-16.9) during 2015-2019, and 10.7% (95% CI, 7.5-14.9) during 2020-2022. The use of the 2020-2022 HBV prevalence estimates corresponded to 870,000 cases of chronic HBV infection (uncertainty interval, 610,000-1,213,000), or approximately one in nine people. The highest HBV seroprevalence estimates were among adolescents aged 10-17 years (17.0%; 95% CI, 8.8-30.5), Ebola survivors (36.8%; 95% CI, 26.2-48.8), people living with HIV (15.9%; 95% CI, 10.6-23.0), and those in the Northern Province (19.0%; 95% CI, 6.4-44.7) and Southern Province (19.7%; 95% CI, 10.9-32.8) regions. These findings may help inform national HBV program implementation in Sierra Leone.
dc.format	Electronic-Print
dc.language	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartof	Am J Trop Med Hyg
dc.relation.isbasedon	10.4269/ajtmh.22-0711
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences
dc.subject.classification	Tropical Medicine
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.subject.mesh	Adolescent
dc.subject.mesh	Humans
dc.subject.mesh	Hepatitis B, Chronic
dc.subject.mesh	Seroepidemiologic Studies
dc.subject.mesh	Prevalence
dc.subject.mesh	Sierra Leone
dc.subject.mesh	Hepatitis B
dc.subject.mesh	Hepatitis B virus
dc.subject.mesh	Hepatitis B Surface Antigens
dc.subject.mesh	Humans
dc.subject.mesh	Hepatitis B virus
dc.subject.mesh	Hepatitis B
dc.subject.mesh	Hepatitis B, Chronic
dc.subject.mesh	Hepatitis B Surface Antigens
dc.subject.mesh	Prevalence
dc.subject.mesh	Seroepidemiologic Studies
dc.subject.mesh	Adolescent
dc.subject.mesh	Sierra Leone
dc.subject.mesh	Adolescent
dc.subject.mesh	Humans
dc.subject.mesh	Hepatitis B, Chronic
dc.subject.mesh	Seroepidemiologic Studies
dc.subject.mesh	Prevalence
dc.subject.mesh	Sierra Leone
dc.subject.mesh	Hepatitis B
dc.subject.mesh	Hepatitis B virus
dc.subject.mesh	Hepatitis B Surface Antigens
dc.title	Prevalence of Chronic Hepatitis B Virus Infection in Sierra Leone, 1997-2022: A Systematic Review and Meta-Analysis.
dc.type	Journal Article
utslib.citation.volume	109
utslib.location.activity	United States
utslib.for	11 Medical and Health Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2023-09-19T02:53:56Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	109
utslib.citation.issue	1

Abstract:

Hepatitis B virus (HBV) infection is a major public health problem in Sierra Leone, yet reliable estimates of cases are lacking. This study aimed to provide an estimate of the national prevalence of chronic HBV infection in the general population and select groups in Sierra Leone. We used the electronic databases PubMed/MEDLINE, Embase, Scopus, ScienceDirect, Web of Science, Google Scholar, and African Journals Online to systematically review articles reporting hepatitis B infection surface antigen seroprevalence estimates in Sierra Leone during 1997-2022. We estimated pooled HBV seroprevalence rates and assessed potential sources of heterogeneity. Of 546 publications screened, 22 studies with a total sample size of 107,186 people were included in the systematic review and meta-analysis. The pooled prevalence of chronic HBV infection was 13.0% (95% CI, 10.0-16.0) (I2 = 99%; Pheterogeneity < 0.01). During the study period, the HBV prevalence rates were as follows: 17.9% (95% CI, 6.7-39.8) before 2015, 13.3% (95% CI, 10.4-16.9) during 2015-2019, and 10.7% (95% CI, 7.5-14.9) during 2020-2022. The use of the 2020-2022 HBV prevalence estimates corresponded to 870,000 cases of chronic HBV infection (uncertainty interval, 610,000-1,213,000), or approximately one in nine people. The highest HBV seroprevalence estimates were among adolescents aged 10-17 years (17.0%; 95% CI, 8.8-30.5), Ebola survivors (36.8%; 95% CI, 26.2-48.8), people living with HIV (15.9%; 95% CI, 10.6-23.0), and those in the Northern Province (19.0%; 95% CI, 6.4-44.7) and Southern Province (19.7%; 95% CI, 10.9-32.8) regions. These findings may help inform national HBV program implementation in Sierra Leone.

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http://hdl.handle.net/10453/172198