Inorganic nanoparticles in dermopharmaceutical and cosmetic products: properties, formulation development, toxicity, and regulatory issues.

Mascarenhas-Melo, F; Mathur, A; Murugappan, S; Sharma, A; Tanwar, K; Dua, K; Kumar Singh, S; Gava Mazzola, P; Nagalaxmi Yadav, D; Kumar Rengan, A; Veiga, F; Cláudia Paiva-Santos, A

Inorganic nanoparticles in dermopharmaceutical and cosmetic products: properties, formulation development, toxicity, and regulatory issues.

Mascarenhas-Melo, F Mathur, A Murugappan, S Sharma, A Tanwar, K Dua, K

Kumar Singh, S Gava Mazzola, P Nagalaxmi Yadav, D Kumar Rengan, A Veiga, F Cláudia Paiva-Santos, A

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Eur J Pharm Biopharm, 2023, pp. S0939-6411(23)00244-8
Issue Date:: 2023-09-20

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Field	Value	Language
dc.contributor.author	Mascarenhas-Melo, F
dc.contributor.author	Mathur, A
dc.contributor.author	Murugappan, S
dc.contributor.author	Sharma, A
dc.contributor.author	Tanwar, K
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Kumar Singh, S
dc.contributor.author	Gava Mazzola, P
dc.contributor.author	Nagalaxmi Yadav, D
dc.contributor.author	Kumar Rengan, A
dc.contributor.author	Veiga, F
dc.contributor.author	Cláudia Paiva-Santos, A
dc.date.accessioned	2023-09-30T08:41:02Z
dc.date.available	2023-09-19
dc.date.available	2023-09-30T08:41:02Z
dc.date.issued	2023-09-20
dc.identifier.citation	Eur J Pharm Biopharm, 2023, pp. S0939-6411(23)00244-8
dc.identifier.issn	0939-6411
dc.identifier.issn	1873-3441
dc.identifier.uri	http://hdl.handle.net/10453/172409
dc.description.abstract	The use of nanotechnology strategies is a current hot topic, and research in this field has been growing significantly in the cosmetics industry. Inorganic nanoparticles stand out in this context for their distinctive physicochemical properties, leading in particular to an increased refractive index and absorption capacity giving them a broad potential for cutaneous applications and making them of special interest in research for dermopharmaceutical and cosmetic purposes. This performance is responsible for its heavy inclusion in the manufacture of skin health products such as sunscreens, lotions, beauty creams, skin ointments, makeup, and others. In particular, their suitable bandgap energy characteristics allow them to be used as photocatalytic semiconductors. They provide excellent UV absorption, commonly known as UV filters, and are responsible for their wide worldwide use in sunscreen formulations without the undesirable white residue after consumer application. In addition, cosmetics based on inorganic nanoparticles have several additional characteristics relevant to formulation development, such as being less expensive compared to other nanomaterials, having greater stability, and ensuring less irritation, itching, and propensity for skin allergies. This review will address in detail the main inorganic nanoparticles used in dermopharmaceutical and cosmetic products, such as titanium dioxide, zinc oxide, silicon dioxide, silver, gold, copper, and aluminum nanoparticles, nanocrystals, and quantum dots, reporting their physicochemical characteristics, but also their additional intrinsic properties that contribute to their use in this type of formulations. Safety issues regarding inorganic nanoparticles, based on toxicity studies, both to humans and the environment, as well as regulatory affairs associated with their use in dermopharmaceuticals and cosmetics, will be addressed.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Eur J Pharm Biopharm
dc.relation.isbasedon	10.1016/j.ejpb.2023.09.011
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	Inorganic nanoparticles in dermopharmaceutical and cosmetic products: properties, formulation development, toxicity, and regulatory issues.
dc.type	Journal Article
utslib.location.activity	Netherlands
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2023-09-30T08:40:56Z
pubs.publication-status	Published online

Abstract:

The use of nanotechnology strategies is a current hot topic, and research in this field has been growing significantly in the cosmetics industry. Inorganic nanoparticles stand out in this context for their distinctive physicochemical properties, leading in particular to an increased refractive index and absorption capacity giving them a broad potential for cutaneous applications and making them of special interest in research for dermopharmaceutical and cosmetic purposes. This performance is responsible for its heavy inclusion in the manufacture of skin health products such as sunscreens, lotions, beauty creams, skin ointments, makeup, and others. In particular, their suitable bandgap energy characteristics allow them to be used as photocatalytic semiconductors. They provide excellent UV absorption, commonly known as UV filters, and are responsible for their wide worldwide use in sunscreen formulations without the undesirable white residue after consumer application. In addition, cosmetics based on inorganic nanoparticles have several additional characteristics relevant to formulation development, such as being less expensive compared to other nanomaterials, having greater stability, and ensuring less irritation, itching, and propensity for skin allergies. This review will address in detail the main inorganic nanoparticles used in dermopharmaceutical and cosmetic products, such as titanium dioxide, zinc oxide, silicon dioxide, silver, gold, copper, and aluminum nanoparticles, nanocrystals, and quantum dots, reporting their physicochemical characteristics, but also their additional intrinsic properties that contribute to their use in this type of formulations. Safety issues regarding inorganic nanoparticles, based on toxicity studies, both to humans and the environment, as well as regulatory affairs associated with their use in dermopharmaceuticals and cosmetics, will be addressed.

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http://hdl.handle.net/10453/172409