Nutritional status and its determinants among adolescents with HIV on anti-retroviral treatment in low- and middle-income countries: a systematic review and meta-analysis.

Gebrie, M; Perry, L; Xu, X; Kassa, A; Cruickshank, M

Nutritional status and its determinants among adolescents with HIV on anti-retroviral treatment in low- and middle-income countries: a systematic review and meta-analysis.

Gebrie, M Perry, L

Xu, X

Kassa, A Cruickshank, M

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: BMC Nutr, 2023, 9, (1), pp. 60
Issue Date:: 2023-03-28

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Field	Value	Language
dc.contributor.author	Gebrie, M
dc.contributor.author	Perry, L https://orcid.org/0000-0002-8507-1283
dc.contributor.author	Xu, X https://orcid.org/0000-0003-4787-6547
dc.contributor.author	Kassa, A
dc.contributor.author	Cruickshank, M https://orcid.org/0000-0001-9890-3141
dc.date.accessioned	2023-10-06T05:23:23Z
dc.date.available	2023-03-15
dc.date.available	2023-10-06T05:23:23Z
dc.date.issued	2023-03-28
dc.identifier.citation	BMC Nutr, 2023, 9, (1), pp. 60
dc.identifier.issn	2055-0928
dc.identifier.issn	2055-0928
dc.identifier.uri	http://hdl.handle.net/10453/172560
dc.description.abstract	PURPOSE: This review aimed to determine what methods are used to assess nutritional status, the levels of nutritional status, determinants of undernutrition, and nutritional interventions employed for adolescents with HIV on Anti-Retroviral Therapy follow-up in Low- and Middle-Income countries. METHODS: Established methods were used to systematically identify and retrieve studies published in five databases between January 2000 to May 2021, and citation searching. Quality was appraised and findings were synthesized using narrative analysis and meta-analysis. RESULT: Body Mass Index is the major indicator of nutritional status. The pooled prevalence of stunting, wasting, and overweight were 28.0%, 17.0%, and 5.0%, respectively. Adolescent males are 1.85 and 2.55 times more likely than adolescent females to suffer from both stunting and wasting at AOR = 1.85 (95%:1.47, 2.31) and AOR = 2.55 (95%: 1.88, 3.48), respectively. Similarly, adolescents with a history of opportunistic infections were 2.97 times more likely to be stunted than uninfected adolescents, AOR = 2.97 (95%:1.73, 5.12). One single intervention study found significant improvements in anthropometric status after nutritional supplementation. CONCLUSION AND RECOMMENDATION: The few studies that have been conducted on nutritional status in adolescents living with HIV in low- and middle-income countries indicate that stunting and wasting are common in this population. Avoiding opportunistic infections is an important protective factor but the review highlighted the generally inadequate and fragmented nature of nutritional screening and support programs. Development of comprehensive and integrated systems for nutritional assessment and intervention services during ART follow-up should be prioritized to improve adolescent clinical outcomes and survival.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	BMC Nutr
dc.relation.isbasedon	10.1186/s40795-023-00714-z
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	3210 Nutrition and dietetics
dc.title	Nutritional status and its determinants among adolescents with HIV on anti-retroviral treatment in low- and middle-income countries: a systematic review and meta-analysis.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHSP - Health Services and Practice
utslib.copyright.status	open_access	*
dc.date.updated	2023-10-06T05:23:22Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	9
utslib.citation.issue	1

Abstract:

PURPOSE: This review aimed to determine what methods are used to assess nutritional status, the levels of nutritional status, determinants of undernutrition, and nutritional interventions employed for adolescents with HIV on Anti-Retroviral Therapy follow-up in Low- and Middle-Income countries. METHODS: Established methods were used to systematically identify and retrieve studies published in five databases between January 2000 to May 2021, and citation searching. Quality was appraised and findings were synthesized using narrative analysis and meta-analysis. RESULT: Body Mass Index is the major indicator of nutritional status. The pooled prevalence of stunting, wasting, and overweight were 28.0%, 17.0%, and 5.0%, respectively. Adolescent males are 1.85 and 2.55 times more likely than adolescent females to suffer from both stunting and wasting at AOR = 1.85 (95%:1.47, 2.31) and AOR = 2.55 (95%: 1.88, 3.48), respectively. Similarly, adolescents with a history of opportunistic infections were 2.97 times more likely to be stunted than uninfected adolescents, AOR = 2.97 (95%:1.73, 5.12). One single intervention study found significant improvements in anthropometric status after nutritional supplementation. CONCLUSION AND RECOMMENDATION: The few studies that have been conducted on nutritional status in adolescents living with HIV in low- and middle-income countries indicate that stunting and wasting are common in this population. Avoiding opportunistic infections is an important protective factor but the review highlighted the generally inadequate and fragmented nature of nutritional screening and support programs. Development of comprehensive and integrated systems for nutritional assessment and intervention services during ART follow-up should be prioritized to improve adolescent clinical outcomes and survival.

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