Development of Precision 3D-Printed Medical Implants

Wazir, Hakim Ullah

Development of Precision 3D-Printed Medical Implants

Wazir, Hakim Ullah

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Publication Type:: Thesis
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Wazir, Hakim Ullah
dc.date.accessioned	2023-10-17T21:25:22Z
dc.date.available	2023-10-17T21:25:22Z
dc.date.issued	2023
dc.identifier.uri	http://hdl.handle.net/10453/172746
dc.description	University of Technology Sydney. Faculty of Engineering and Information Technology.	en_US.UTF-8
dc.description.abstract	This research investigated the cellular efficacies of combining biocompatibility and antibacterial properties in biomedical materials. The osteogenic response of both osteoblast and osteocyte cells and the bacteria S. aureus adhesion on a newly developed titanium alloy Ti-12Nb-12Zr-12Sn alloy (Ti12), Ti-6Al-4V alloy (Ti64), and commercially pure titanium (CPT) were investigated. Materials exhibited biocompatibility and demonstrated distinct cell morphological differences with osteoblast and osteocyte cells on the alloy surfaces suggesting Ti64 promoting faster cell migration and Ti12 supporting coordinated cellular responses during bone remodelling due to branched out interconnected dendritic processes, which was supported by gene expression profiles. Interestingly, only the Ti12 alloy inhibited S. aureus bacterial adhesion without negatively affecting bone cell proliferation. This low-modulus Ti-Nb-Zr-Sn alloy presents biocompatible-antibacterial attributes, offering new potential for bone regeneration surgeries. Additionally, aseptic loosening, a common implant failure cause, necessitates arthroplasty revisions. Metal 3D printing enables complex porous implants that enhance osseointegration, reducing aseptic loosening risks. Furthermore, in this research, the osteogenic responses to pre-designed structures of porous titanium alloy samples to optimize bone-implant integration was evaluated. Bone cell morphology and gene expression on porous surfaces indicated that the cells favour dense, compact porous structures, aiding implant design for improved integration and lower Young's modulus. This research bridges the gap between biocompatibility and antibacterial properties, offering innovative solutions for enhanced bone regeneration and implant longevity.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/172746/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2023 Hakim Ullah Wazir
dc.rights	au.edu.uts.lib/cph
dc.title	Development of Precision 3D-Printed Medical Implants	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

This research investigated the cellular efficacies of combining biocompatibility and antibacterial properties in biomedical materials. The osteogenic response of both osteoblast and osteocyte cells and the bacteria S. aureus adhesion on a newly developed titanium alloy Ti-12Nb-12Zr-12Sn alloy (Ti12), Ti-6Al-4V alloy (Ti64), and commercially pure titanium (CPT) were investigated. Materials exhibited biocompatibility and demonstrated distinct cell morphological differences with osteoblast and osteocyte cells on the alloy surfaces suggesting Ti64 promoting faster cell migration and Ti12 supporting coordinated cellular responses during bone remodelling due to branched out interconnected dendritic processes, which was supported by gene expression profiles. Interestingly, only the Ti12 alloy inhibited S. aureus bacterial adhesion without negatively affecting bone cell proliferation. This low-modulus Ti-Nb-Zr-Sn alloy presents biocompatible-antibacterial attributes, offering new potential for bone regeneration surgeries. Additionally, aseptic loosening, a common implant failure cause, necessitates arthroplasty revisions. Metal 3D printing enables complex porous implants that enhance osseointegration, reducing aseptic loosening risks. Furthermore, in this research, the osteogenic responses to pre-designed structures of porous titanium alloy samples to optimize bone-implant integration was evaluated. Bone cell morphology and gene expression on porous surfaces indicated that the cells favour dense, compact porous structures, aiding implant design for improved integration and lower Young's modulus. This research bridges the gap between biocompatibility and antibacterial properties, offering innovative solutions for enhanced bone regeneration and implant longevity.

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http://hdl.handle.net/10453/172746