Application of heliox for optimized drug delivery through respiratory tract

Farooq, U; Riaz, HH; Munir, A; Zhao, M; Tariq, A; Islam, MS

Application of heliox for optimized drug delivery through respiratory tract

Farooq, U Riaz, HH Munir, A Zhao, M Tariq, A Islam, MS

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Publisher:: AIP Publishing
Publication Type:: Journal Article
Citation:: Physics of Fluids, 2023, 35, (10)
Issue Date:: 2023-10-01

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Field	Value	Language
dc.contributor.author	Farooq, U
dc.contributor.author	Riaz, HH
dc.contributor.author	Munir, A
dc.contributor.author	Zhao, M
dc.contributor.author	Tariq, A
dc.contributor.author	Islam, MS
dc.date.accessioned	2023-10-18T06:05:25Z
dc.date.available	2023-10-18T06:05:25Z
dc.date.issued	2023-10-01
dc.identifier.citation	Physics of Fluids, 2023, 35, (10)
dc.identifier.issn	1070-6631
dc.identifier.issn	1089-7666
dc.identifier.uri	http://hdl.handle.net/10453/172797
dc.description.abstract	<jats:p>Understanding the transportation and deposition (TD) of inhaled particles in the upper respiratory tract is crucial for predicting health risks and treating pulmonary diseases. The available literature reports highly turbulent flow in the extrathoracic (ET) region during normal breathing, which leads to higher deposition of the drug aerosol in this region. To improve the targeted deposition of inhaled drugs, in the tracheobronchial airways, it is essential to understand the flow and particle transport dynamics and reduce the turbulence behavior at the ET region. The less-dense heliox gas could reduce the turbulence behavior at the ET; however, the knowledge of heliox inhalation therapies in drug aerosol TD remains underachieved to realize the full potential for assisted breathing and drug delivery. Additionally, the impact of the inhalation of heliox mixed with other gases on particle deposition is missing in the literature. Therefore, this study aims to develop a mixture model to advance the knowledge of inhalation therapy. A heliox (78% helium and 22% oxygen) and a mixture of heliox and air are used to understand the flow behavior and particle TD in airways. The impact of different inhalation and Stokes numbers on the deposition efficiencies in the ideal and age-specific upper airways is studied. The study reports that less-dense heliox gas has lower turbulence intensity and results in lower deposition efficiency in the G3–G5 lung airways compared to air and mixture inhalations. Moreover, slightly higher deposition efficiencies during mixture inhalation as compared to air inhalation are found in the upper airways. The deposition patterns of different inhalations obtained in this study could help improve targeted drug delivery into the upper and deeper lung airways.</jats:p>
dc.language	en
dc.publisher	AIP Publishing
dc.relation.ispartof	Physics of Fluids
dc.relation.isbasedon	10.1063/5.0169934
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	01 Mathematical Sciences, 02 Physical Sciences, 09 Engineering
dc.subject.classification	Fluids & Plasmas
dc.subject.classification	40 Engineering
dc.subject.classification	49 Mathematical sciences
dc.subject.classification	51 Physical sciences
dc.title	Application of heliox for optimized drug delivery through respiratory tract
dc.type	Journal Article
utslib.citation.volume	35
utslib.for	01 Mathematical Sciences
utslib.for	02 Physical Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2024-10-10T00:00:00+1000Z
dc.date.updated	2023-10-18T06:05:24Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	35
utslib.citation.issue	10

Abstract:

Understanding the transportation and deposition (TD) of inhaled particles in the upper respiratory tract is crucial for predicting health risks and treating pulmonary diseases. The available literature reports highly turbulent flow in the extrathoracic (ET) region during normal breathing, which leads to higher deposition of the drug aerosol in this region. To improve the targeted deposition of inhaled drugs, in the tracheobronchial airways, it is essential to understand the flow and particle transport dynamics and reduce the turbulence behavior at the ET region. The less-dense heliox gas could reduce the turbulence behavior at the ET; however, the knowledge of heliox inhalation therapies in drug aerosol TD remains underachieved to realize the full potential for assisted breathing and drug delivery. Additionally, the impact of the inhalation of heliox mixed with other gases on particle deposition is missing in the literature. Therefore, this study aims to develop a mixture model to advance the knowledge of inhalation therapy. A heliox (78% helium and 22% oxygen) and a mixture of heliox and air are used to understand the flow behavior and particle TD in airways. The impact of different inhalation and Stokes numbers on the deposition efficiencies in the ideal and age-specific upper airways is studied. The study reports that less-dense heliox gas has lower turbulence intensity and results in lower deposition efficiency in the G3–G5 lung airways compared to air and mixture inhalations. Moreover, slightly higher deposition efficiencies during mixture inhalation as compared to air inhalation are found in the upper airways. The deposition patterns of different inhalations obtained in this study could help improve targeted drug delivery into the upper and deeper lung airways.

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http://hdl.handle.net/10453/172797