Compelling Impacts of Natural Polymer-Centered Drug Delivery Systems as Prophylactic and Therapeutic Approaches in Various Pulmonary Disorders/Lung Diseases

Gopal, K; Pathak, S; Deruiter, J; Nadar, RM; Ramesh, S; Babu, RJ; Watts Alexander, CS; Dua, K; Clark, R; Moore, T; Dhanasekaran, M

Compelling Impacts of Natural Polymer-Centered Drug Delivery Systems as Prophylactic and Therapeutic Approaches in Various Pulmonary Disorders/Lung Diseases

Gopal, K Pathak, S Deruiter, J Nadar, RM Ramesh, S Babu, RJ Watts Alexander, CS Dua, K

Clark, R Moore, T Dhanasekaran, M

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Publisher:: Springer Nature
Publication Type:: Chapter
Citation:: Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases, 2023, pp. 445-464
Issue Date:: 2023-01-01

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Field	Value	Language
dc.contributor.author	Gopal, K
dc.contributor.author	Pathak, S
dc.contributor.author	Deruiter, J
dc.contributor.author	Nadar, RM
dc.contributor.author	Ramesh, S
dc.contributor.author	Babu, RJ
dc.contributor.author	Watts Alexander, CS
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Clark, R
dc.contributor.author	Moore, T
dc.contributor.author	Dhanasekaran, M
dc.date.accessioned	2023-10-18T23:05:21Z
dc.date.available	2023-10-18T23:05:21Z
dc.date.issued	2023-01-01
dc.identifier.citation	Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases, 2023, pp. 445-464
dc.identifier.isbn	9789811976551
dc.identifier.uri	http://hdl.handle.net/10453/172800
dc.description.abstract	Pulmonary disorders are common illness that affects people of all ages worldwide. Common pulmonary disorders include pulmonary hypertension, CF (cystic fibrosis), asthma, chronic obstructive pulmonary disorder, emphysema, chronic bronchitis, lung cancer, and COVID-19. Treatments of these disorders vary but can be broadly categorized into pharmacological (medicinal), non-pharmacological, rehabilitation, and surgical techniques. Often, a combination of these approaches is used, both for symptomatic relief and treatment. Regarding these prophylactic and therapeutic approaches, advances are rapidly being made, and scientists are currently investigating modern and unique theranostic methods. However, there is a lacuna in drug delivery, pharmacokinetic aspects, and drug-induced adverse effects. One particular area for improvement that needs to be immediately addressed is the drug delivery system to significantly improve healthcare associated with pulmonary disorders. Natural polymer-based drug delivery systems are widely adopted for their ease of production, lack of biotoxicity, and strong bioaffinity. Of the natural polymerbased drug delivery systems, chitosan, sodium alginates, albumin, hydroxyapatite, and hyaluronic acid are the most common natural polymers. Each of these natural polymers has its preferred use, either due to tissue-specific delivery or medical property packaging. The current scientific article discusses the common pulmonary disorders, their pathophysiology, and the current therapeutic approaches. Additionally, we discuss the major natural polymer drug delivery systems, including their properties and common uses.
dc.language	en
dc.publisher	Springer Nature
dc.relation.ispartof	Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases
dc.relation.isbasedon	10.1007/978-981-19-7656-8_24
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	Compelling Impacts of Natural Polymer-Centered Drug Delivery Systems as Prophylactic and Therapeutic Approaches in Various Pulmonary Disorders/Lung Diseases
dc.type	Chapter
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2023-10-18T23:05:19Z
pubs.publication-status	Published

Abstract:

Pulmonary disorders are common illness that affects people of all ages worldwide. Common pulmonary disorders include pulmonary hypertension, CF (cystic fibrosis), asthma, chronic obstructive pulmonary disorder, emphysema, chronic bronchitis, lung cancer, and COVID-19. Treatments of these disorders vary but can be broadly categorized into pharmacological (medicinal), non-pharmacological, rehabilitation, and surgical techniques. Often, a combination of these approaches is used, both for symptomatic relief and treatment. Regarding these prophylactic and therapeutic approaches, advances are rapidly being made, and scientists are currently investigating modern and unique theranostic methods. However, there is a lacuna in drug delivery, pharmacokinetic aspects, and drug-induced adverse effects. One particular area for improvement that needs to be immediately addressed is the drug delivery system to significantly improve healthcare associated with pulmonary disorders. Natural polymer-based drug delivery systems are widely adopted for their ease of production, lack of biotoxicity, and strong bioaffinity. Of the natural polymerbased drug delivery systems, chitosan, sodium alginates, albumin, hydroxyapatite, and hyaluronic acid are the most common natural polymers. Each of these natural polymers has its preferred use, either due to tissue-specific delivery or medical property packaging. The current scientific article discusses the common pulmonary disorders, their pathophysiology, and the current therapeutic approaches. Additionally, we discuss the major natural polymer drug delivery systems, including their properties and common uses.

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http://hdl.handle.net/10453/172800