New horizons in lung cancer management through ATR/CHK1 pathway modulation.

Thapa, R; Afzal, O; Bhat, AA; Goyal, A; Alfawaz Altamimi, AS; Almalki, WH; Alzarea, SI; Kazmi, I; Singh, SK; Dua, K; Thangavelu, L; Gupta, G

New horizons in lung cancer management through ATR/CHK1 pathway modulation.

Thapa, R Afzal, O Bhat, AA Goyal, A Alfawaz Altamimi, AS Almalki, WH Alzarea, SI Kazmi, I Singh, SK Dua, K

Thangavelu, L Gupta, G

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Publication Type:: Journal Article
Citation:: Future Med Chem, 2023
Issue Date:: 2023-10-25

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Field	Value	Language
dc.contributor.author	Thapa, R
dc.contributor.author	Afzal, O
dc.contributor.author	Bhat, AA
dc.contributor.author	Goyal, A
dc.contributor.author	Alfawaz Altamimi, AS
dc.contributor.author	Almalki, WH
dc.contributor.author	Alzarea, SI
dc.contributor.author	Kazmi, I
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Thangavelu, L
dc.contributor.author	Gupta, G
dc.date.accessioned	2023-10-26T01:40:48Z
dc.date.available	2023-10-26T01:40:48Z
dc.date.issued	2023-10-25
dc.identifier.citation	Future Med Chem, 2023
dc.identifier.issn	1756-8927
dc.identifier.uri	http://hdl.handle.net/10453/172862
dc.description.abstract	Lung cancer is the leading cause of cancer-related deaths worldwide. Molecular profiling has contributed to a new classification of lung cancer, driving advancements in research and therapy. The ataxia telangiectasia and rad3/checkpoint kinase 1 (ATR/CHK1) pathway plays a crucial role in maintaining genomic stability, and its activation has been linked to the development of lung cancer, drug resistance and poor prognosis. Clinical and preclinical studies have demonstrated promising results in targeting this pathway. ATR and CHK1 are proteins that collaborate to repair DNA damage caused by radiation or chemotherapy. ATR/CHK1 inhibitors are currently under investigation in preclinical and clinical trials. This article explores the ATR/CHK1 pathway and its potential for treating lung cancer.
dc.language	eng
dc.relation.ispartof	Future Med Chem
dc.relation.isbasedon	10.4155/fmc-2023-0164
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.classification	3404 Medicinal and biomolecular chemistry
dc.title	New horizons in lung cancer management through ATR/CHK1 pathway modulation.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2023-10-26T01:40:47Z
pubs.publication-status	Published online

Abstract:

Lung cancer is the leading cause of cancer-related deaths worldwide. Molecular profiling has contributed to a new classification of lung cancer, driving advancements in research and therapy. The ataxia telangiectasia and rad3/checkpoint kinase 1 (ATR/CHK1) pathway plays a crucial role in maintaining genomic stability, and its activation has been linked to the development of lung cancer, drug resistance and poor prognosis. Clinical and preclinical studies have demonstrated promising results in targeting this pathway. ATR and CHK1 are proteins that collaborate to repair DNA damage caused by radiation or chemotherapy. ATR/CHK1 inhibitors are currently under investigation in preclinical and clinical trials. This article explores the ATR/CHK1 pathway and its potential for treating lung cancer.

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http://hdl.handle.net/10453/172862