Immunopathology of herpes simplex virus-associated neuroinflammation: Unveiling the mysteries.

Hussain, MS; Gupta, G; Samuel, VP; Almalki, WH; Kazmi, I; Alzarea, SI; Saleem, S; Khan, R; Altwaijry, N; Patel, S; Patel, A; Singh, SK; Dua, K

Immunopathology of herpes simplex virus-associated neuroinflammation: Unveiling the mysteries.

Hussain, MS Gupta, G Samuel, VP Almalki, WH Kazmi, I Alzarea, SI Saleem, S Khan, R Altwaijry, N Patel, S Patel, A Singh, SK Dua, K

Permalink

Publisher:: Wiley
Publication Type:: Journal Article
Citation:: Rev Med Virol, 2023, pp. e2491
Issue Date:: 2023-11-20

Closed Access

	Filename	Description	Size
	Herpes simplex virus_neuroinflammation.pdf	Published version	1.29 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Hussain, MS
dc.contributor.author	Gupta, G
dc.contributor.author	Samuel, VP
dc.contributor.author	Almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Alzarea, SI
dc.contributor.author	Saleem, S
dc.contributor.author	Khan, R
dc.contributor.author	Altwaijry, N
dc.contributor.author	Patel, S
dc.contributor.author	Patel, A
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2023-11-23T06:11:51Z
dc.date.available	2023-11-03
dc.date.available	2023-11-23T06:11:51Z
dc.date.issued	2023-11-20
dc.identifier.citation	Rev Med Virol, 2023, pp. e2491
dc.identifier.issn	1052-9276
dc.identifier.issn	1099-1654
dc.identifier.uri	http://hdl.handle.net/10453/173521
dc.description.abstract	The immunopathology of herpes simplex virus (HSV)-associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes the outcome of these infections. This review delves into the multifaceted immune reactions triggered by HSV within neural tissues, intricately encompassing the interplay between innate and adaptive immunity. Furthermore, this analysis delves into the delicate equilibrium between immune defence and the potential for immunopathology-induced neural damage. It meticulously dissects the roles of diverse immune cells, cytokines, and chemokines, unravelling the intricacies of neuroinflammation modulation and its subsequent effects. By exploring HSV's immune manipulation and exploitation mechanisms, this review endeavours to unveil the enigmas surrounding the immunopathology of HSV-associated neuroinflammation. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of HSV infections.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Wiley
dc.relation.ispartof	Rev Med Virol
dc.relation.isbasedon	10.1002/rmv.2491
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1108 Medical Microbiology
dc.subject.classification	Virology
dc.subject.classification	3107 Microbiology
dc.title	Immunopathology of herpes simplex virus-associated neuroinflammation: Unveiling the mysteries.
dc.type	Journal Article
utslib.location.activity	England
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2023-11-23T06:11:50Z
pubs.publication-status	Published online

Abstract:

The immunopathology of herpes simplex virus (HSV)-associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes the outcome of these infections. This review delves into the multifaceted immune reactions triggered by HSV within neural tissues, intricately encompassing the interplay between innate and adaptive immunity. Furthermore, this analysis delves into the delicate equilibrium between immune defence and the potential for immunopathology-induced neural damage. It meticulously dissects the roles of diverse immune cells, cytokines, and chemokines, unravelling the intricacies of neuroinflammation modulation and its subsequent effects. By exploring HSV's immune manipulation and exploitation mechanisms, this review endeavours to unveil the enigmas surrounding the immunopathology of HSV-associated neuroinflammation. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of HSV infections.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/173521