From Plants to Therapies: Exploring the Pharmacology of Coumestrol for Neurological Conditions.

Singla, M; Verma, S; Thakur, K; Goyal, A; Sharma, V; Sharma, D; Porwal, O; Subramaniyan, V; Behl, T; Singh, SK; Dua, K; Gupta, G; Gupta, S

From Plants to Therapies: Exploring the Pharmacology of Coumestrol for Neurological Conditions.

Singla, M Verma, S Thakur, K Goyal, A Sharma, V Sharma, D Porwal, O Subramaniyan, V Behl, T Singh, SK Dua, K

Gupta, G Gupta, S

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Curr Med Chem, 2023, 31
Issue Date:: 2023-10-26

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Field	Value	Language
dc.contributor.author	Singla, M
dc.contributor.author	Verma, S
dc.contributor.author	Thakur, K
dc.contributor.author	Goyal, A
dc.contributor.author	Sharma, V
dc.contributor.author	Sharma, D
dc.contributor.author	Porwal, O
dc.contributor.author	Subramaniyan, V
dc.contributor.author	Behl, T
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gupta, G
dc.contributor.author	Gupta, S
dc.date.accessioned	2023-11-25T06:22:31Z
dc.date.available	2023-09-11
dc.date.available	2023-11-25T06:22:31Z
dc.date.issued	2023-10-26
dc.identifier.citation	Curr Med Chem, 2023, 31
dc.identifier.issn	0929-8673
dc.identifier.issn	1875-533X
dc.identifier.uri	http://hdl.handle.net/10453/173551
dc.description.abstract	Neurological disorders are possibly the most prevalent and have been identified to occur among individuals with autism beyond chance. These disorders encompass a diverse range of consequences with neurological causes and have been regarded as a major threat to public mental health. There is no tried-and-true approach for completely protecting the nervous system. Therefore, plant-derived compounds have developed significantly nowadays. Coumestrol (CML) is a potent isoflavone phytoestrogen with a protective effect against neurological dysfunction and has been discovered to be structurally and functionally similar to estrogen. In recent years, more research has been undertaken on phytoestrogens. This research demonstrates the biological complexity of phytoestrogens, which consist of multiple chemical families and function in various ways. This review aimed to explore recent findings on the most significant pharmacological advantages of CML by emphasising neurological benefits. Numerous CML extraction strategies and their pharmacological effects on various neurological disorders, including PD, AD, HD, anxiety, and cognitive impairments, were also documented.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Bentham Science Publishers Ltd.
dc.relation.ispartof	Curr Med Chem
dc.relation.isbasedon	10.2174/0109298673250784231011094322
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0304 Medicinal and Biomolecular Chemistry, 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.classification	3404 Medicinal and biomolecular chemistry
dc.title	From Plants to Therapies: Exploring the Pharmacology of Coumestrol for Neurological Conditions.
dc.type	Journal Article
utslib.citation.volume	31
utslib.location.activity	United Arab Emirates
utslib.for	0304 Medicinal and Biomolecular Chemistry
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	embargoed	*
utslib.copyright.embargo	2024-10-26T00:00:00+1000Z
dc.date.updated	2023-11-25T06:22:29Z
pubs.publication-status	Published online
pubs.volume	31

Abstract:

Neurological disorders are possibly the most prevalent and have been identified to occur among individuals with autism beyond chance. These disorders encompass a diverse range of consequences with neurological causes and have been regarded as a major threat to public mental health. There is no tried-and-true approach for completely protecting the nervous system. Therefore, plant-derived compounds have developed significantly nowadays. Coumestrol (CML) is a potent isoflavone phytoestrogen with a protective effect against neurological dysfunction and has been discovered to be structurally and functionally similar to estrogen. In recent years, more research has been undertaken on phytoestrogens. This research demonstrates the biological complexity of phytoestrogens, which consist of multiple chemical families and function in various ways. This review aimed to explore recent findings on the most significant pharmacological advantages of CML by emphasising neurological benefits. Numerous CML extraction strategies and their pharmacological effects on various neurological disorders, including PD, AD, HD, anxiety, and cognitive impairments, were also documented.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/173551