Association between physical activity levels and healing in people with venous leg ulcers: secondary analysis of prospective cohort data

Qiu, Y; Osadnik, CR; Brusco, NK; Sussman, G; Reeves, J; Gleghorn, L; Weller, CD; Team, V

Association between physical activity levels and healing in people with venous leg ulcers: secondary analysis of prospective cohort data

Qiu, Y Osadnik, CR Brusco, NK Sussman, G Reeves, J Gleghorn, L Weller, CD Team, V

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Publisher:: Frontiers
Publication Type:: Journal Article
Citation:: Frontiers in Medicine, 10, pp. 1305594

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Field	Value	Language
dc.contributor.author	Qiu, Y
dc.contributor.author	Osadnik, CR
dc.contributor.author	Brusco, NK
dc.contributor.author	Sussman, G
dc.contributor.author	Reeves, J
dc.contributor.author	Gleghorn, L
dc.contributor.author	Weller, CD
dc.contributor.author	Team, V
dc.date.accessioned	2024-01-09T09:06:55Z
dc.date.available	2024-01-09T09:06:55Z
dc.identifier.citation	Frontiers in Medicine, 10, pp. 1305594
dc.identifier.issn	2296-858X
dc.identifier.issn	2296-858X
dc.identifier.uri	http://hdl.handle.net/10453/174165
dc.description.abstract	<jats:sec><jats:title>Aim</jats:title><jats:p>To explore the relationship between physical activity levels and wound healing and recurrence in people with venous leg ulcers.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Questionnaires and medical records were used to collect data, with responses used to group participants into different physical activity groups. The differences in healing and recurrence outcomes of ulcers among different physical activity groups were compared using Chi-square, Kaplan Meier survival analysis, Cox proportional hazards regression analysis, and Kruskal-Wallis test. To measure the strength of the association between physical activity levels and patient outcomes, Spearman’s Rho tests were used. We used descriptive analysis to examine how physical activity levels change over 24 weeks.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Participants were classified into four distinct groups based on physical activity levels reported at baseline and week 12. The survival analysis showed higher physical activity level was associated with a shorter time to healing (log-rank test = 14.78, <jats:italic>df</jats:italic> = 3; <jats:italic>p</jats:italic> = 0.002). The persistently moderate-to-vigorous group had a 7.3-fold increased likelihood of healing compared to the persistently sedentary group. High levels of physical activity were also associated with a better quality of life score at baseline (<jats:inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>ρ</mml:mi></mml:math></jats:inline-formula> = 0.41, <jats:italic>p</jats:italic> < 0.000), week 12 (<jats:inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>ρ</mml:mi></mml:math></jats:inline-formula> = 0.36, <jats:italic>p</jats:italic> < 0.001), and week 24 (<jats:inline-formula><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>ρ</mml:mi></mml:math></jats:inline-formula> = 0.49, <jats:italic>p</jats:italic> < 0.000). Most participants (48.5%) reported low levels of physical activity, which remained low for the entire study period.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>An increased level of physical activity was linked to a shorter healing time and enhanced quality of life. Low levels of physical activity appeared common among people with venous leg ulcers.</jats:p></jats:sec>
dc.language	en
dc.publisher	Frontiers
dc.relation.ispartof	Frontiers in Medicine
dc.relation.isbasedon	10.3389/fmed.2023.1305594
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.title	Association between physical activity levels and healing in people with venous leg ulcers: secondary analysis of prospective cohort data
dc.type	Journal Article
utslib.citation.volume	10
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2024-01-09T09:06:54Z
pubs.publication-status	Published online
pubs.volume	10

Abstract:

AimTo explore the relationship between physical activity levels and wound healing and recurrence in people with venous leg ulcers.MethodsQuestionnaires and medical records were used to collect data, with responses used to group participants into different physical activity groups. The differences in healing and recurrence outcomes of ulcers among different physical activity groups were compared using Chi-square, Kaplan Meier survival analysis, Cox proportional hazards regression analysis, and Kruskal-Wallis test. To measure the strength of the association between physical activity levels and patient outcomes, Spearman’s Rho tests were used. We used descriptive analysis to examine how physical activity levels change over 24 weeks.ResultsParticipants were classified into four distinct groups based on physical activity levels reported at baseline and week 12. The survival analysis showed higher physical activity level was associated with a shorter time to healing (log-rank test = 14.78, df = 3; p = 0.002). The persistently moderate-to-vigorous group had a 7.3-fold increased likelihood of healing compared to the persistently sedentary group. High levels of physical activity were also associated with a better quality of life score at baseline (ρ = 0.41, p < 0.000), week 12 (ρ = 0.36, p < 0.001), and week 24 (ρ = 0.49, p < 0.000). Most participants (48.5%) reported low levels of physical activity, which remained low for the entire study period.ConclusionAn increased level of physical activity was linked to a shorter healing time and enhanced quality of life. Low levels of physical activity appeared common among people with venous leg ulcers.

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http://hdl.handle.net/10453/174165