Exercise and the gut microbiome: implications for supportive care in cancer.

Hart, NH; Wallen, MP; Farley, MJ; Haywood, D; Boytar, AN; Secombe, K; Joseph, R; Chan, RJ; Kenkhuis, M-F; Buffart, LM; Skinner, TL; Wardill, HR

Exercise and the gut microbiome: implications for supportive care in cancer.

Hart, NH Wallen, MP Farley, MJ Haywood, D

Boytar, AN Secombe, K Joseph, R Chan, RJ Kenkhuis, M-F Buffart, LM Skinner, TL Wardill, HR

Permalink

Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Support Care Cancer, 2023, 31, (12), pp. 724
Issue Date:: 2023-11-28

Closed Access

	Filename	Description	Size
	s00520-023-08183-7.pdf		1.16 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Hart, NH
dc.contributor.author	Wallen, MP
dc.contributor.author	Farley, MJ
dc.contributor.author	Haywood, D https://orcid.org/0000-0002-9317-4135
dc.contributor.author	Boytar, AN
dc.contributor.author	Secombe, K
dc.contributor.author	Joseph, R
dc.contributor.author	Chan, RJ
dc.contributor.author	Kenkhuis, M-F
dc.contributor.author	Buffart, LM
dc.contributor.author	Skinner, TL
dc.contributor.author	Wardill, HR
dc.date.accessioned	2024-01-11T01:31:07Z
dc.date.available	2023-11-12
dc.date.available	2024-01-11T01:31:07Z
dc.date.issued	2023-11-28
dc.identifier.citation	Support Care Cancer, 2023, 31, (12), pp. 724
dc.identifier.issn	0941-4355
dc.identifier.issn	1433-7339
dc.identifier.uri	http://hdl.handle.net/10453/174268
dc.description.abstract	PURPOSE: Growing recognition of the gut microbiome as an influential modulator of cancer treatment efficacy and toxicity has led to the emergence of clinical interventions targeting the microbiome to enhance cancer and health outcomes. The highly modifiable nature of microbiota to endogenous, exogenous, and environmental inputs enables interventions to promote resilience of the gut microbiome that have rapid effects on host health, or response to cancer treatment. While diet, probiotics, and faecal microbiota transplant are primary avenues of therapy focused on restoring or protecting gut function in people undergoing cancer treatment, the role of physical activity and exercise has scarcely been examined in this population. METHODS: A narrative review was conducted to explore the nexus between cancer care and the gut microbiome in the context of physical activity and exercise as a widely available and clinically effective supportive care strategy used by cancer survivors. RESULTS: Exercise can facilitate a more diverse gut microbiome and functional metabolome in humans; however, most physical activity and exercise studies have been conducted in healthy or athletic populations, primarily using aerobic exercise modalities. A scarcity of exercise and microbiome studies in cancer exists. CONCLUSIONS: Exercise remains an attractive avenue to promote microbiome health in cancer survivors. Future research should elucidate the various influences of exercise modalities, intensities, frequencies, durations, and volumes to explore dose-response relationships between exercise and the gut microbiome among cancer survivors, as well as multifaceted approaches (such as diet and probiotics), and examine the influences of exercise on the gut microbiome and associated symptom burden prior to, during, and following cancer treatment.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Support Care Cancer
dc.relation.isbasedon	10.1007/s00520-023-08183-7
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.classification	32 Biomedical and clinical sciences
dc.subject.classification	42 Health sciences
dc.subject.classification	52 Psychology
dc.subject.mesh	Humans
dc.subject.mesh	Gastrointestinal Microbiome
dc.subject.mesh	Exercise
dc.subject.mesh	Neoplasms
dc.subject.mesh	Diet
dc.subject.mesh	Sports
dc.subject.mesh	Probiotics
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Exercise
dc.subject.mesh	Diet
dc.subject.mesh	Sports
dc.subject.mesh	Probiotics
dc.subject.mesh	Gastrointestinal Microbiome
dc.title	Exercise and the gut microbiome: implications for supportive care in cancer.
dc.type	Journal Article
utslib.citation.volume	31
utslib.location.activity	Germany
utslib.for	11 Medical and Health Sciences
utslib.for	17 Psychology and Cognitive Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - HPRC - Human Performance Research Centre
utslib.copyright.status	closed_access	*
dc.date.updated	2024-01-11T01:31:06Z
pubs.issue	12
pubs.publication-status	Published online
pubs.volume	31
utslib.citation.issue	12

Abstract:

PURPOSE: Growing recognition of the gut microbiome as an influential modulator of cancer treatment efficacy and toxicity has led to the emergence of clinical interventions targeting the microbiome to enhance cancer and health outcomes. The highly modifiable nature of microbiota to endogenous, exogenous, and environmental inputs enables interventions to promote resilience of the gut microbiome that have rapid effects on host health, or response to cancer treatment. While diet, probiotics, and faecal microbiota transplant are primary avenues of therapy focused on restoring or protecting gut function in people undergoing cancer treatment, the role of physical activity and exercise has scarcely been examined in this population. METHODS: A narrative review was conducted to explore the nexus between cancer care and the gut microbiome in the context of physical activity and exercise as a widely available and clinically effective supportive care strategy used by cancer survivors. RESULTS: Exercise can facilitate a more diverse gut microbiome and functional metabolome in humans; however, most physical activity and exercise studies have been conducted in healthy or athletic populations, primarily using aerobic exercise modalities. A scarcity of exercise and microbiome studies in cancer exists. CONCLUSIONS: Exercise remains an attractive avenue to promote microbiome health in cancer survivors. Future research should elucidate the various influences of exercise modalities, intensities, frequencies, durations, and volumes to explore dose-response relationships between exercise and the gut microbiome among cancer survivors, as well as multifaceted approaches (such as diet and probiotics), and examine the influences of exercise on the gut microbiome and associated symptom burden prior to, during, and following cancer treatment.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/174268