Localized Delivery of Bioactives using Structured Liposomal Gels.

Kumar, D; Dua, K; Tiwari, S

Localized Delivery of Bioactives using Structured Liposomal Gels.

Kumar, D Dua, K

Tiwari, S

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Publisher:: Bentham Science Publishers
Publication Type:: Journal Article
Citation:: Curr Pharm Des, 2023, 29, (40), pp. 3206-3220
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Kumar, D
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Tiwari, S
dc.date.accessioned	2024-01-29T01:38:36Z
dc.date.available	2023-10-03
dc.date.available	2024-01-29T01:38:36Z
dc.date.issued	2023
dc.identifier.citation	Curr Pharm Des, 2023, 29, (40), pp. 3206-3220
dc.identifier.issn	1381-6128
dc.identifier.issn	1873-4286
dc.identifier.uri	http://hdl.handle.net/10453/174989
dc.description.abstract	Liposomes have gained a lot of interest for drug delivery applications, and some of these preparations have been commercialized. These are formulated with biocompatible components and can be used for delivering a wide range of payloads differing in aqueous solubility and molecular weight. Liposome-based delivery approaches are limited mainly by two factors: (a) poor dispersion stability, and (b) pre-mature leakage of payloads. In this review, we have discussed the stabilization of liposomal vesicles by their entrapment in hydrogels. Studies reveal that such hydrogels can maintain the structural integrity of liposomes. Release of liposomes from the hydrogel network can be modulated through careful screening of matrix former and degree of its cross-linking. Accordingly, we have reviewed the approaches of stabilizing liposomal vesicles through entrapment in hydrogels. Application of liposome-embedded hydrogels has been reviewed in context of localized drug delivery. Our discussion is focussed on the delivery of bioactives to the skin. Such an approach appears alluring from the standpoint of minimizing the undesirable distribution of payload(s) the systemic circulation and off-target sites.
dc.format	Print
dc.language	eng
dc.publisher	Bentham Science Publishers
dc.relation.ispartof	Curr Pharm Des
dc.relation.isbasedon	10.2174/0113816128263001231102053654
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Medicinal & Biomolecular Chemistry
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.mesh	Humans
dc.subject.mesh	Liposomes
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Skin
dc.subject.mesh	Gels
dc.subject.mesh	Skin Absorption
dc.subject.mesh	Hydrogels
dc.subject.mesh	Skin
dc.subject.mesh	Humans
dc.subject.mesh	Liposomes
dc.subject.mesh	Gels
dc.subject.mesh	Hydrogels
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Skin Absorption
dc.title	Localized Delivery of Bioactives using Structured Liposomal Gels.
dc.type	Journal Article
utslib.citation.volume	29
utslib.location.activity	United Arab Emirates
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2024-01-29T01:38:34Z
pubs.issue	40
pubs.publication-status	Published
pubs.volume	29
utslib.citation.issue	40

Abstract:

Liposomes have gained a lot of interest for drug delivery applications, and some of these preparations have been commercialized. These are formulated with biocompatible components and can be used for delivering a wide range of payloads differing in aqueous solubility and molecular weight. Liposome-based delivery approaches are limited mainly by two factors: (a) poor dispersion stability, and (b) pre-mature leakage of payloads. In this review, we have discussed the stabilization of liposomal vesicles by their entrapment in hydrogels. Studies reveal that such hydrogels can maintain the structural integrity of liposomes. Release of liposomes from the hydrogel network can be modulated through careful screening of matrix former and degree of its cross-linking. Accordingly, we have reviewed the approaches of stabilizing liposomal vesicles through entrapment in hydrogels. Application of liposome-embedded hydrogels has been reviewed in context of localized drug delivery. Our discussion is focussed on the delivery of bioactives to the skin. Such an approach appears alluring from the standpoint of minimizing the undesirable distribution of payload(s) the systemic circulation and off-target sites.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/174989