UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW
- Publication Type:
- Journal Article
- EXCLI Journal, 2024, 23, pp. 34-52
- Issue Date:
This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, in-cluding cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes opti-mistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's cru-cial role in LC.
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