UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW

Hussain, MS; Afzal, O; Gupta, G; Goyal, A; Almalki, WH; Kazmi, I; Alzarea, SI; Altamimi, ASA; Kukreti, N; Chakraborty, A; Singh, SK; Dua, K

UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW

Hussain, MS Afzal, O Gupta, G Goyal, A Almalki, WH Kazmi, I Alzarea, SI Altamimi, ASA Kukreti, N Chakraborty, A Singh, SK Dua, K

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Publication Type:: Journal Article
Citation:: EXCLI Journal, 2024, 23, pp. 34-52
Issue Date:: 2024-01-03

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Field	Value	Language
dc.contributor.author	Hussain, MS
dc.contributor.author	Afzal, O
dc.contributor.author	Gupta, G
dc.contributor.author	Goyal, A
dc.contributor.author	Almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Alzarea, SI
dc.contributor.author	Altamimi, ASA
dc.contributor.author	Kukreti, N
dc.contributor.author	Chakraborty, A
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2024-02-10T04:46:47Z
dc.date.available	2024-02-10T04:46:47Z
dc.date.issued	2024-01-03
dc.identifier.citation	EXCLI Journal, 2024, 23, pp. 34-52
dc.identifier.issn	1611-2156
dc.identifier.uri	http://hdl.handle.net/10453/175555
dc.description.abstract	This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, in-cluding cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes opti-mistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's cru-cial role in LC.
dc.language	en
dc.relation.ispartof	EXCLI Journal
dc.relation.isbasedon	10.17179/excli2023-6553
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	This is an Open Access article distributed under the terms of the Creative Commons Attribution License
dc.subject.classification	Toxicology
dc.title	UNRAVELING NEAT1'S COMPLEX ROLE IN LUNG CANCER BIOLOGY: A COMPREHENSIVE REVIEW
dc.type	Journal Article
utslib.citation.volume	23
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2024-02-10T04:46:46Z
pubs.publication-status	Published
pubs.volume	23

Abstract:

This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, in-cluding cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically. The review concludes opti-mistically, suggesting future avenues for research and personalized LC therapies, shedding light on NEAT1's cru-cial role in LC.

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http://hdl.handle.net/10453/175555