Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study.

Nguyen, HT; Nguyen, BT; Thai, THN; Tran, AV; Nguyen, TT; Vo, T; Mai, LD; Tran, TS; Nguyen, TV; Ho-Pham, LT

Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study.

Nguyen, HT Nguyen, BT Thai, THN Tran, AV Nguyen, TT Vo, T Mai, LD Tran, TS Nguyen, TV Ho-Pham, LT

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Sci Rep, 2024, 14, (1), pp. 32
Issue Date:: 2024-01-02

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Field	Value	Language
dc.contributor.author	Nguyen, HT
dc.contributor.author	Nguyen, BT
dc.contributor.author	Thai, THN
dc.contributor.author	Tran, AV
dc.contributor.author	Nguyen, TT
dc.contributor.author	Vo, T
dc.contributor.author	Mai, LD
dc.contributor.author	Tran, TS
dc.contributor.author	Nguyen, TV
dc.contributor.author	Ho-Pham, LT
dc.date.accessioned	2024-02-27T06:41:06Z
dc.date.available	2023-12-15
dc.date.available	2024-02-27T06:41:06Z
dc.date.issued	2024-01-02
dc.identifier.citation	Sci Rep, 2024, 14, (1), pp. 32
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/175903
dc.description.abstract	The epidemiology of vertebral fractures (VF) in underrepresented populations is not well-documented. This cohort study was part of a longitudinal osteoporosis research project with the aim of determining the prevalence, incidence, and risk factors for VF. 401 individuals (155 men) aged 50 years and older without a clinical diagnosis of VF were took radiographs at baseline and 2 years later. VF were ascertained using the Genant's semi-quantitative method. Bone mineral density (BMD) of femoral neck and lumbar spine were measured by dual-energy X-ray absorptiometry (Hologic Inc). The association between VF and risk factors was analyzed by the multiple logistic regression. The 95% confidence interval for prevalence and incidence was estimated by exact Poisson test. At baseline, the prevalence of VF was 12.2% (n = 49, 95% CI 9.0-16.2%) and increased with advancing age with one-fifth of those aged 70 and older having a VF. During the follow-up period, we observed 6 new VF, making the incidence of 6.6/1000 person-years (n = 6, 95% CI 2.4-14.3). The risk of prevalent VF was associated with male gender (OR: 2.67; 95% CI 1.28-5.87) and T-score at the femoral neck (OR per one SD decrease: 1.1; 1.03-1.17). These data indicate that VF is common among adults, and that lower femoral neck BMD was a risk factor for VF.
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Sci Rep
dc.relation.isbasedon	10.1038/s41598-023-50145-w
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject.mesh	Adult
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Middle Aged
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Spinal Fractures
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Prevalence
dc.subject.mesh	Incidence
dc.subject.mesh	Vietnam
dc.subject.mesh	Osteoporosis
dc.subject.mesh	Bone Density
dc.subject.mesh	Absorptiometry, Photon
dc.subject.mesh	Risk Factors
dc.subject.mesh	Lumbar Vertebrae
dc.subject.mesh	Lumbar Vertebrae
dc.subject.mesh	Humans
dc.subject.mesh	Osteoporosis
dc.subject.mesh	Spinal Fractures
dc.subject.mesh	Absorptiometry, Photon
dc.subject.mesh	Incidence
dc.subject.mesh	Prevalence
dc.subject.mesh	Risk Factors
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Bone Density
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Middle Aged
dc.subject.mesh	Vietnam
dc.subject.mesh	Male
dc.subject.mesh	Adult
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Middle Aged
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 and over
dc.subject.mesh	Spinal Fractures
dc.subject.mesh	Cohort Studies
dc.subject.mesh	Prevalence
dc.subject.mesh	Incidence
dc.subject.mesh	Vietnam
dc.subject.mesh	Osteoporosis
dc.subject.mesh	Bone Density
dc.subject.mesh	Absorptiometry, Photon
dc.subject.mesh	Risk Factors
dc.subject.mesh	Lumbar Vertebrae
dc.title	Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study.
dc.type	Journal Article
utslib.citation.volume	14
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	recently_added	*
dc.date.updated	2024-02-27T06:41:02Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	14
utslib.citation.issue	1

Abstract:

The epidemiology of vertebral fractures (VF) in underrepresented populations is not well-documented. This cohort study was part of a longitudinal osteoporosis research project with the aim of determining the prevalence, incidence, and risk factors for VF. 401 individuals (155 men) aged 50 years and older without a clinical diagnosis of VF were took radiographs at baseline and 2 years later. VF were ascertained using the Genant's semi-quantitative method. Bone mineral density (BMD) of femoral neck and lumbar spine were measured by dual-energy X-ray absorptiometry (Hologic Inc). The association between VF and risk factors was analyzed by the multiple logistic regression. The 95% confidence interval for prevalence and incidence was estimated by exact Poisson test. At baseline, the prevalence of VF was 12.2% (n = 49, 95% CI 9.0-16.2%) and increased with advancing age with one-fifth of those aged 70 and older having a VF. During the follow-up period, we observed 6 new VF, making the incidence of 6.6/1000 person-years (n = 6, 95% CI 2.4-14.3). The risk of prevalent VF was associated with male gender (OR: 2.67; 95% CI 1.28-5.87) and T-score at the femoral neck (OR per one SD decrease: 1.1; 1.03-1.17). These data indicate that VF is common among adults, and that lower femoral neck BMD was a risk factor for VF.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/175903