| Field |
Value |
Language |
|
dc.contributor.author |
Rennie, C
https://orcid.org/0000-0003-4533-6627
|
|
|
dc.contributor.author |
Huang, Y |
|
|
dc.contributor.author |
Siwakoti, P |
|
|
dc.contributor.author |
Du, Z |
|
|
dc.contributor.author |
Padula, M
https://orcid.org/0000-0002-8283-0643
|
|
|
dc.contributor.author |
Bao, G
https://orcid.org/0000-0001-5103-5009
|
|
|
dc.contributor.author |
Tuch, BE |
|
|
dc.contributor.author |
Xu, X
https://orcid.org/0000-0002-2598-3766
|
|
|
dc.contributor.author |
McClements, L
https://orcid.org/0000-0002-4911-1014
|
|
|
dc.date.accessioned |
2024-03-07T23:42:13Z |
|
|
dc.date.available |
2024-03-07T23:42:13Z |
|
|
dc.date.issued |
2023-01 |
|
|
dc.identifier.citation |
Nanomedicine (Lond), 2023, 18, (1), pp. 53-66 |
|
|
dc.identifier.issn |
1743-5889 |
|
|
dc.identifier.issn |
1748-6963 |
|
|
dc.identifier.uri |
http://hdl.handle.net/10453/176319
|
|
|
dc.description.abstract |
Background: Implantation of insulin-secreting cells has been trialed as a treatment for Type 1 diabetes mellitus; however, the host immunogenic response limits their effectiveness. Methodology: The authors developed a core-shell nanostructure of upconversion nanoparticle-mesoporous silica for controlled local delivery of an immunomodulatory agent, MCC950, using near-infrared light and validated it in in vitro models of fibrosis. Results: The individual components of the nanosystem did not affect the proliferation of insulin-secreting cells, unlike fibroblast proliferation (p < 0.01). The nanosystem is effective at releasing MCC950 and preventing fibroblast differentiation (p < 0.01), inflammation (IL-6 expression; p < 0.05) and monocyte adhesion (p < 0.01). Conclusion: This MCC950-loaded nanomedicine system could be used in the future together with insulin-secreting cell implants to increase their longevity as a curative treatment for Type 1 diabetes mellitus. |
|
|
dc.format |
Print-Electronic |
|
|
dc.language |
eng |
|
|
dc.publisher |
FUTURE MEDICINE LTD |
|
|
dc.relation |
Juvenile Diabetes Foundation InternationalJDRF International: 1-INO-2020-914-A-N |
|
|
dc.relation.ispartof |
Nanomedicine (Lond) |
|
|
dc.relation.isbasedon |
10.2217/nnm-2022-0231 |
|
|
dc.rights |
info:eu-repo/semantics/embargoedAccess |
|
|
dc.subject |
0306 Physical Chemistry (incl. Structural), 1004 Medical Biotechnology, 1007 Nanotechnology |
|
|
dc.subject.classification |
Nanoscience & Nanotechnology |
|
|
dc.subject.classification |
3206 Medical biotechnology |
|
|
dc.subject.classification |
4003 Biomedical engineering |
|
|
dc.subject.classification |
4018 Nanotechnology |
|
|
dc.subject.mesh |
Humans |
|
|
dc.subject.mesh |
Diabetes Mellitus, Type 1 |
|
|
dc.subject.mesh |
Drug Delivery Systems |
|
|
dc.subject.mesh |
Nanoparticles |
|
|
dc.subject.mesh |
Nanostructures |
|
|
dc.subject.mesh |
Humans |
|
|
dc.subject.mesh |
Diabetes Mellitus, Type 1 |
|
|
dc.subject.mesh |
Drug Delivery Systems |
|
|
dc.subject.mesh |
Nanostructures |
|
|
dc.subject.mesh |
Nanoparticles |
|
|
dc.subject.mesh |
Humans |
|
|
dc.subject.mesh |
Diabetes Mellitus, Type 1 |
|
|
dc.subject.mesh |
Drug Delivery Systems |
|
|
dc.subject.mesh |
Nanoparticles |
|
|
dc.subject.mesh |
Nanostructures |
|
|
dc.title |
In vitro evaluation of a hybrid drug-delivery nanosystem for fibrosis prevention in cell therapy for Type 1 diabetes. |
|
|
dc.type |
Journal Article |
|
|
utslib.citation.volume |
18 |
|
|
utslib.location.activity |
England |
|
|
utslib.for |
0306 Physical Chemistry (incl. Structural) |
|
|
utslib.for |
1004 Medical Biotechnology |
|
|
utslib.for |
1007 Nanotechnology |
|
|
pubs.organisational-group |
University of Technology Sydney |
|
|
pubs.organisational-group |
University of Technology Sydney/Faculty of Engineering and Information Technology |
|
|
pubs.organisational-group |
University of Technology Sydney/Faculty of Science |
|
|
pubs.organisational-group |
University of Technology Sydney/Faculty of Science/School of Life Sciences |
|
|
pubs.organisational-group |
University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences |
|
|
pubs.organisational-group |
University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering |
|
|
pubs.organisational-group |
University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices |
|
|
utslib.copyright.status |
open_access |
* |
|
utslib.copyright.embargo |
2024-03-20T00:00:00+1000Z |
|
|
dc.date.updated |
2024-03-07T23:42:11Z |
|
|
pubs.issue |
1 |
|
|
pubs.publication-status |
Published |
|
|
pubs.volume |
18 |
|
|
utslib.citation.issue |
1 |
|
