An X-ray activatable gold nanorod encapsulated liposome delivery system for mitochondria-targeted photodynamic therapy (PDT).

Gu, X; Shu, T; Deng, W; Shen, C; Wu, Y

An X-ray activatable gold nanorod encapsulated liposome delivery system for mitochondria-targeted photodynamic therapy (PDT).

Gu, X Shu, T Deng, W

Shen, C Wu, Y

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Publisher:: Royal Society of Chemistry (RSC)
Publication Type:: Journal Article
Citation:: J Mater Chem B, 2023, 11, (20), pp. 4539-4547
Issue Date:: 2023-05-24

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Field	Value	Language
dc.contributor.author	Gu, X
dc.contributor.author	Shu, T
dc.contributor.author	Deng, W https://orcid.org/0000-0002-9413-0978
dc.contributor.author	Shen, C
dc.contributor.author	Wu, Y
dc.date.accessioned	2024-03-15T04:45:31Z
dc.date.available	2024-03-15T04:45:31Z
dc.date.issued	2023-05-24
dc.identifier.citation	J Mater Chem B, 2023, 11, (20), pp. 4539-4547
dc.identifier.issn	2050-750X
dc.identifier.issn	2050-7518
dc.identifier.uri	http://hdl.handle.net/10453/176780
dc.description.abstract	In this work, we developed a mitochondria-targeted nanomaterial for neoadjuvant X-ray-triggered photodynamic therapy of rectal cancer. Herein, we designed a biodegradable liposome incorporating a photosensitizer, verteporfin, to generate X-ray-induced reactive oxygen species, gold nanorods as radiation enhancers, and triphenylphosphonium as the mitochondrial targeting moiety. The average size of the nanocarrier was about 150 nm. Due to the synergetic effect between X-ray and a combination of verteporfin and gold nanorods, as well as precise site-targeted TPP-modified liposomal nanocarriers, our nanoconjugates generated sufficient cytotoxic singlet oxygen within the mitochondria under X-ray irradiation, triggering the loss of membrane potential and mitochondria-related apoptosis of cancer cells.
dc.format	Electronic
dc.language	eng
dc.publisher	Royal Society of Chemistry (RSC)
dc.relation	http://purl.org/au-research/grants/nhmrc/1181889
dc.relation.ispartof	J Mater Chem B
dc.relation.isbasedon	10.1039/d3tb00608e
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0903 Biomedical Engineering
dc.subject.classification	3403 Macromolecular and materials chemistry
dc.subject.classification	4003 Biomedical engineering
dc.subject.classification	4004 Chemical engineering
dc.subject.mesh	Liposomes
dc.subject.mesh	Verteporfin
dc.subject.mesh	X-Rays
dc.subject.mesh	Gold
dc.subject.mesh	Photochemotherapy
dc.subject.mesh	Nanotubes
dc.subject.mesh	Mitochondria
dc.subject.mesh	Mitochondria
dc.subject.mesh	Gold
dc.subject.mesh	Liposomes
dc.subject.mesh	Photochemotherapy
dc.subject.mesh	X-Rays
dc.subject.mesh	Nanotubes
dc.subject.mesh	Verteporfin
dc.subject.mesh	Liposomes
dc.subject.mesh	Verteporfin
dc.subject.mesh	X-Rays
dc.subject.mesh	Gold
dc.subject.mesh	Photochemotherapy
dc.subject.mesh	Nanotubes
dc.subject.mesh	Mitochondria
dc.title	An X-ray activatable gold nanorod encapsulated liposome delivery system for mitochondria-targeted photodynamic therapy (PDT).
dc.type	Journal Article
utslib.citation.volume	11
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0903 Biomedical Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2024-04-27T00:00:00+1000Z
dc.date.updated	2024-03-15T04:45:29Z
pubs.issue	20
pubs.publication-status	Published online
pubs.volume	11
utslib.citation.issue	20

Abstract:

In this work, we developed a mitochondria-targeted nanomaterial for neoadjuvant X-ray-triggered photodynamic therapy of rectal cancer. Herein, we designed a biodegradable liposome incorporating a photosensitizer, verteporfin, to generate X-ray-induced reactive oxygen species, gold nanorods as radiation enhancers, and triphenylphosphonium as the mitochondrial targeting moiety. The average size of the nanocarrier was about 150 nm. Due to the synergetic effect between X-ray and a combination of verteporfin and gold nanorods, as well as precise site-targeted TPP-modified liposomal nanocarriers, our nanoconjugates generated sufficient cytotoxic singlet oxygen within the mitochondria under X-ray irradiation, triggering the loss of membrane potential and mitochondria-related apoptosis of cancer cells.

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http://hdl.handle.net/10453/176780