Volumetric response and pattern of failure of histone altered high grade glioma in adults following management with radiation therapy

Knight, A; Horsley, P; Yuile, A; Yim, J; Suh, M; Venketesha, V; Kastelan, M; Wheeler, H; Back, M

Volumetric response and pattern of failure of histone altered high grade glioma in adults following management with radiation therapy

Knight, A Horsley, P Yuile, A Yim, J Suh, M Venketesha, V Kastelan, M Wheeler, H Back, M

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Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: Journal of Neuro-Oncology, 2023, 163, (1), pp. 281-288
Issue Date:: 2023-05

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Field	Value	Language
dc.contributor.author	Knight, A
dc.contributor.author	Horsley, P
dc.contributor.author	Yuile, A
dc.contributor.author	Yim, J
dc.contributor.author	Suh, M
dc.contributor.author	Venketesha, V
dc.contributor.author	Kastelan, M
dc.contributor.author	Wheeler, H
dc.contributor.author	Back, M
dc.date.accessioned	2024-03-26T22:13:14Z
dc.date.available	2023-05-03
dc.date.available	2024-03-26T22:13:14Z
dc.date.issued	2023-05
dc.identifier.citation	Journal of Neuro-Oncology, 2023, 163, (1), pp. 281-288
dc.identifier.issn	0167-594X
dc.identifier.issn	1573-7373
dc.identifier.uri	http://hdl.handle.net/10453/177197
dc.description.abstract	PurposeH3K27M and H3G34R mutant gliomas are recently classified subgroups of high grade gliomas HGGs affecting younger adults This study aimed to describe patterns of infiltration and failure and the volumetric response of these tumours to radiotherapy MethodsPatients with histone mutant gliomas aged 16 50 years managed from 2009 to 2021 were identified and clinical radiological and histopathological characteristics collected Tumour volume was assessed on MRI at diagnosis pre radiotherapy month 1 3 and 5 post radiation and at relapse ResultsOf 538 IDH1 2 wild type HGGs 18 15 had a histone alteration Eleven were H3K27M and 7 H3G34R mutant respectively Median age at diagnosis was 20 years range17 48 years Median overall survival was 20 months 95 CI 14 29 months Both H3K27M and H3G34R mutant tumours exhibited extensive T2F infiltration involving a median of 4 neuroanatomical subsites at diagnosis Median volume of disease pre radiotherapy on T1gd and T2F respectively was 0 5cm3 IQR 0 1 7cm3 and 11 9 cm3 IQR 7 5 29 6cm3 for H3K27M and 0 9cm3 IQR 0 8 4cm3 and 43 8cm3 IQR 25 2 86 6 cm3 for H3G34R tumours T2F volume reduction 50 was observed 3 months post IMRT in 7 64 patients with H3K27M and 1 14 with H3G34R tumours Fourteen patients had relapsed Relapse was local only distant only and both in 4 44 3 33 and 2 22 H3K27M mutant and 1 20 2 40 and 2 40 H3G34R mutant tumours On last scan before death leptomeningeal spread was present in 4 8 50 and 1 5 20 and subependymal spread in 4 8 50 and 0 5 H3K27M and G34R mutant cases respectively ConclusionH3K27M mutant gliomas are highly responsive to radiotherapy but exhibit high propensity for subsequent leptomeningeal and subependymal spread H3G34R mutant tumours exhibit lesser early volumetric response to radiotherapy and propensity for distant in brain failure
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	Journal of Neuro-Oncology
dc.relation.isbasedon	10.1007/s11060-023-04332-4
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1109 Neurosciences, 1112 Oncology and Carcinogenesis
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.classification	3209 Neurosciences
dc.subject.classification	3211 Oncology and carcinogenesis
dc.subject.mesh	Humans
dc.subject.mesh	Adult
dc.subject.mesh	Adolescent
dc.subject.mesh	Young Adult
dc.subject.mesh	Middle Aged
dc.subject.mesh	Histones
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Prognosis
dc.subject.mesh	Mutation
dc.subject.mesh	Neoplasm Recurrence, Local
dc.subject.mesh	Glioma
dc.subject.mesh	Humans
dc.subject.mesh	Glioma
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Neoplasm Recurrence, Local
dc.subject.mesh	Histones
dc.subject.mesh	Prognosis
dc.subject.mesh	Mutation
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Middle Aged
dc.subject.mesh	Young Adult
dc.subject.mesh	Humans
dc.subject.mesh	Adult
dc.subject.mesh	Adolescent
dc.subject.mesh	Young Adult
dc.subject.mesh	Middle Aged
dc.subject.mesh	Histones
dc.subject.mesh	Brain Neoplasms
dc.subject.mesh	Prognosis
dc.subject.mesh	Mutation
dc.subject.mesh	Neoplasm Recurrence, Local
dc.subject.mesh	Glioma
dc.title	Volumetric response and pattern of failure of histone altered high grade glioma in adults following management with radiation therapy
dc.type	Journal Article
utslib.citation.volume	163
utslib.location.activity	United States
utslib.for	1109 Neurosciences
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Centre for Health Economics Research and Evaluation
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2024-03-26T22:13:12Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	163
utslib.citation.issue	1

Abstract:

PurposeH3K27M and H3G34R mutant gliomas are recently classified subgroups of high grade gliomas HGGs affecting younger adults This study aimed to describe patterns of infiltration and failure and the volumetric response of these tumours to radiotherapy MethodsPatients with histone mutant gliomas aged 16 50 years managed from 2009 to 2021 were identified and clinical radiological and histopathological characteristics collected Tumour volume was assessed on MRI at diagnosis pre radiotherapy month 1 3 and 5 post radiation and at relapse ResultsOf 538 IDH1 2 wild type HGGs 18 15 had a histone alteration Eleven were H3K27M and 7 H3G34R mutant respectively Median age at diagnosis was 20 years range17 48 years Median overall survival was 20 months 95 CI 14 29 months Both H3K27M and H3G34R mutant tumours exhibited extensive T2F infiltration involving a median of 4 neuroanatomical subsites at diagnosis Median volume of disease pre radiotherapy on T1gd and T2F respectively was 0 5cm3 IQR 0 1 7cm3 and 11 9 cm3 IQR 7 5 29 6cm3 for H3K27M and 0 9cm3 IQR 0 8 4cm3 and 43 8cm3 IQR 25 2 86 6 cm3 for H3G34R tumours T2F volume reduction 50 was observed 3 months post IMRT in 7 64 patients with H3K27M and 1 14 with H3G34R tumours Fourteen patients had relapsed Relapse was local only distant only and both in 4 44 3 33 and 2 22 H3K27M mutant and 1 20 2 40 and 2 40 H3G34R mutant tumours On last scan before death leptomeningeal spread was present in 4 8 50 and 1 5 20 and subependymal spread in 4 8 50 and 0 5 H3K27M and G34R mutant cases respectively ConclusionH3K27M mutant gliomas are highly responsive to radiotherapy but exhibit high propensity for subsequent leptomeningeal and subependymal spread H3G34R mutant tumours exhibit lesser early volumetric response to radiotherapy and propensity for distant in brain failure

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http://hdl.handle.net/10453/177197