P08.08.A EXPLORATION OF SURVIVORSHIP ISSUES AND QUALITY OF LIFE IN A COHORT OF IDH MUTATED HIGH GRADE GLIOMA 5 YEARS FOLLOWING DEFINITIVE TREATMENT
- Publisher:
- Oxford University Press (OUP)
- Publication Type:
- Journal Article
- Citation:
- Neuro-Oncology, 2023, 25, (Supplement_2), pp. ii57-ii57
- Issue Date:
- 2023-09-08
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Abstract BACKGROUND Approximately 2000 people are diagnosed with brain cancer in Australia each year Compared to glioblastoma patients the IDH mutated high grade glioma IDHmHGG is a more favourable diagnosis better prognosis and survival outcomes Coupled with improved treatments the IDHmHGG cohort is living longer which means treatment side effects eg fatigue cognitive deficits physical limitations etc can significantly impact their quality of life in the survivorship years Hence there is a need to identify and determine the survivorship issues most pertinent for the IDHmHGG cohort MATERIAL AND METHODS A mixed METHODS cross sectional study was conducted to investigate the relationship between socio demographic clinical factors and quality of life in the IDHmHGG cohort Qualitative data collection consisted of a neuro oncology clinician focus group n 11 regarding survivorship issues and was contrasted with semi structured patient interviews n 27 Quantitative data collection n 41 involved socio demographic questions the Functional Assessment of Cancer Therapy Brain FACT Br tool and The Hospital Anxiety and Depression Scale HADS RESULTS The results indicate that marital status employment status and treatment complications are strongly associated with quality of life in IDHmHGG patients Being single and unemployed is associated with lower quality of life p 0 05 Similarly our findings show that psychological distress specifically the presence of anxiety and depressive symptoms is a major factor that can negatively impact the QoL in an IDHmHGG cohort The order of ranking between clinician and patient identified issues only matched for physical limitations ranked 3rd Although not matched in ranking both groups identified cognitive function employment social function isolation and mental health as commonly experienced in the survivorship years CONCLUSION This study highlights the importance of considering socio demographic and clinical factors in the care and support of brai
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