Is cortical inhibition in primary motor cortex related to executive control?

Loomes, M; Tran, DMD; Chowdhury, NS; Birney, DP; Harris, JA; Livesey, EJ

Is cortical inhibition in primary motor cortex related to executive control?

Loomes, M

Tran, DMD Chowdhury, NS Birney, DP Harris, JA Livesey, EJ

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Cortex, 2023, 160, pp. 100-114
Issue Date:: 2023-03

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Field	Value	Language
dc.contributor.author	Loomes, M https://orcid.org/0000-0003-1042-0968
dc.contributor.author	Tran, DMD
dc.contributor.author	Chowdhury, NS
dc.contributor.author	Birney, DP
dc.contributor.author	Harris, JA
dc.contributor.author	Livesey, EJ
dc.date.accessioned	2024-03-28T05:13:54Z
dc.date.available	2022-12-05
dc.date.available	2024-03-28T05:13:54Z
dc.date.issued	2023-03
dc.identifier.citation	Cortex, 2023, 160, pp. 100-114
dc.identifier.issn	0010-9452
dc.identifier.issn	1973-8102
dc.identifier.uri	http://hdl.handle.net/10453/177348
dc.description.abstract	Recent research using paired-pulse transcranial magnetic stimulation (TMS) has shown that the speed with which people can stop an action is linked to GABAergic inhibitory activity in the motor system. Specifically, a significant proportion of the variance in stop signal reaction time (SSRT; a widely used measure of inhibitory control) is accounted for by short-interval cortical inhibition (SICI). It is still unclear whether this relationship reflects a broader link between GABAergic processes and executive functions, or a specific link between GABAergic processes and motor stopping ability. The current study sought to replicate the correlation between SSRT and SICI while investigating whether this association generalises to other measures of inhibitory control and working memory, and to long-interval cortical inhibition (LICI). Participants completed a battery of inhibition (Stop-Signal, Stroop, Flanker) and working memory (n-back, Digit Span, and Operation Span) tasks. We replicated the correlation between SICI and SSRT but found no other correlations between behavioural measures of executive control and the two cortical measures of inhibition. These findings indicate that the relationship between SSRT and SICI is specific to a particular property of response inhibition and likely reflects the function of local inhibitory networks mediated by GABAA.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	Cortex
dc.relation.isbasedon	10.1016/j.cortex.2022.12.013
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1109 Neurosciences, 1701 Psychology, 1702 Cognitive Sciences
dc.subject.classification	Experimental Psychology
dc.subject.classification	3209 Neurosciences
dc.subject.classification	5202 Biological psychology
dc.subject.classification	5204 Cognitive and computational psychology
dc.subject.mesh	Humans
dc.subject.mesh	Executive Function
dc.subject.mesh	Motor Cortex
dc.subject.mesh	Neural Inhibition
dc.subject.mesh	Evoked Potentials, Motor
dc.subject.mesh	Reaction Time
dc.subject.mesh	Transcranial Magnetic Stimulation
dc.subject.mesh	Electromyography
dc.subject.mesh	Motor Cortex
dc.subject.mesh	Humans
dc.subject.mesh	Electromyography
dc.subject.mesh	Reaction Time
dc.subject.mesh	Evoked Potentials, Motor
dc.subject.mesh	Neural Inhibition
dc.subject.mesh	Transcranial Magnetic Stimulation
dc.subject.mesh	Executive Function
dc.subject.mesh	Humans
dc.subject.mesh	Executive Function
dc.subject.mesh	Motor Cortex
dc.subject.mesh	Neural Inhibition
dc.subject.mesh	Evoked Potentials, Motor
dc.subject.mesh	Reaction Time
dc.subject.mesh	Transcranial Magnetic Stimulation
dc.subject.mesh	Electromyography
dc.title	Is cortical inhibition in primary motor cortex related to executive control?
dc.type	Journal Article
utslib.citation.volume	160
utslib.location.activity	Italy
utslib.for	1109 Neurosciences
utslib.for	1701 Psychology
utslib.for	1702 Cognitive Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2024-03-28T05:13:53Z
pubs.publication-status	Published
pubs.volume	160

Abstract:

Recent research using paired-pulse transcranial magnetic stimulation (TMS) has shown that the speed with which people can stop an action is linked to GABAergic inhibitory activity in the motor system. Specifically, a significant proportion of the variance in stop signal reaction time (SSRT; a widely used measure of inhibitory control) is accounted for by short-interval cortical inhibition (SICI). It is still unclear whether this relationship reflects a broader link between GABAergic processes and executive functions, or a specific link between GABAergic processes and motor stopping ability. The current study sought to replicate the correlation between SSRT and SICI while investigating whether this association generalises to other measures of inhibitory control and working memory, and to long-interval cortical inhibition (LICI). Participants completed a battery of inhibition (Stop-Signal, Stroop, Flanker) and working memory (n-back, Digit Span, and Operation Span) tasks. We replicated the correlation between SICI and SSRT but found no other correlations between behavioural measures of executive control and the two cortical measures of inhibition. These findings indicate that the relationship between SSRT and SICI is specific to a particular property of response inhibition and likely reflects the function of local inhibitory networks mediated by GABAA.

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http://hdl.handle.net/10453/177348