Tricuspid Regurgitation After Heart Transplantation: The Cause or the Result of Graft Dysfunction?
Bart, NK
Hungerford, SL
Namasivayam, M
Granger, E
Conellan, M
Kotlyar, E
Muthiah, K
Jabbour, A
Hayward, C
Jansz, PC
Keogh, AM
Macdonald, PS
- Publisher:
- Wolters Kluwer
- Publication Type:
- Journal Article
- Citation:
- Transplantation, 2023, 107, (6), pp. 1390-1397
- Issue Date:
- 2023-06-01
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Tricuspid Regurgitation After Heart Transplantation_ The Cause or the Result of Graft Dysfunction_.pdf | Published version | 655.33 kB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Bart, NK | |
dc.contributor.author | Hungerford, SL | |
dc.contributor.author | Namasivayam, M | |
dc.contributor.author | Granger, E | |
dc.contributor.author | Conellan, M | |
dc.contributor.author | Kotlyar, E | |
dc.contributor.author | Muthiah, K | |
dc.contributor.author | Jabbour, A | |
dc.contributor.author | Hayward, C | |
dc.contributor.author | Jansz, PC | |
dc.contributor.author | Keogh, AM | |
dc.contributor.author | Macdonald, PS | |
dc.date.accessioned | 2024-04-09T22:44:33Z | |
dc.date.available | 2024-04-09T22:44:33Z | |
dc.date.issued | 2023-06-01 | |
dc.identifier.citation | Transplantation, 2023, 107, (6), pp. 1390-1397 | |
dc.identifier.issn | 0041-1337 | |
dc.identifier.issn | 1534-6080 | |
dc.identifier.uri | http://hdl.handle.net/10453/177633 | |
dc.description.abstract | BACKGROUND: Tricuspid regurgitation (TR) is common following heart transplantation and has been shown to adversely influence patient outcomes. The aim of this study was to identify causes of progression to moderate-severe TR in the first 2 y after transplantation. METHODS: This was a retrospective, single-center study of all patients who underwent heart transplantation over a 6-y period. Transthoracic echocardiogram (TTE) was performed at month 0, between 6 and 12 mo, and 1-2 y postoperatively to determine the presence and severity of TR. RESULTS: A total of 163 patients were included, of whom 142 underwent TTE before first endomyocardial biopsy. At month 0, 127 (78%) patients had nil-mild TR before first biopsy, whereas 36 (22%) had moderate-severe TR. In patients with nil-mild TR, 9 (7%) progressed to moderate-severe TR by 6 mo and 1 underwent tricuspid valve (TV) surgery. Of patients with moderate-severe TR before first biopsy, by 2 y, 3 had undergone TV surgery. The use of postoperative extracorporeal membrane oxygenation (ECMO) in the latter group was significant (78%; P < 0.05) as was rejection profile ( P = 0.02). Patients with late progressive moderate-severe TR had a significantly higher 2-y mortality than those who had moderate-severe TR immediately. CONCLUSIONS: Overall, our study has shown that in the 2 main groups of interest (early moderate-severe TR and progression from nil-mild to moderate-severe TR), TR is more likely to be the result of significant underling graft dysfunction rather than the cause of it. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Wolters Kluwer | |
dc.relation.ispartof | Transplantation | |
dc.relation.isbasedon | 10.1097/TP.0000000000004511 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 11 Medical and Health Sciences | |
dc.subject.classification | Surgery | |
dc.subject.classification | 3202 Clinical sciences | |
dc.subject.classification | 3204 Immunology | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Tricuspid Valve Insufficiency | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Heart Transplantation | |
dc.subject.mesh | Echocardiography | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Tricuspid Valve Insufficiency | |
dc.subject.mesh | Echocardiography | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Heart Transplantation | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Tricuspid Valve Insufficiency | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Heart Transplantation | |
dc.subject.mesh | Echocardiography | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Treatment Outcome | |
dc.title | Tricuspid Regurgitation After Heart Transplantation: The Cause or the Result of Graft Dysfunction? | |
dc.type | Journal Article | |
utslib.citation.volume | 107 | |
utslib.location.activity | United States | |
utslib.for | 11 Medical and Health Sciences | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Health | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2024-04-09T22:44:31Z | |
pubs.issue | 6 | |
pubs.publication-status | Published | |
pubs.volume | 107 | |
utslib.citation.issue | 6 |
Abstract:
BACKGROUND: Tricuspid regurgitation (TR) is common following heart transplantation and has been shown to adversely influence patient outcomes. The aim of this study was to identify causes of progression to moderate-severe TR in the first 2 y after transplantation. METHODS: This was a retrospective, single-center study of all patients who underwent heart transplantation over a 6-y period. Transthoracic echocardiogram (TTE) was performed at month 0, between 6 and 12 mo, and 1-2 y postoperatively to determine the presence and severity of TR. RESULTS: A total of 163 patients were included, of whom 142 underwent TTE before first endomyocardial biopsy. At month 0, 127 (78%) patients had nil-mild TR before first biopsy, whereas 36 (22%) had moderate-severe TR. In patients with nil-mild TR, 9 (7%) progressed to moderate-severe TR by 6 mo and 1 underwent tricuspid valve (TV) surgery. Of patients with moderate-severe TR before first biopsy, by 2 y, 3 had undergone TV surgery. The use of postoperative extracorporeal membrane oxygenation (ECMO) in the latter group was significant (78%; P < 0.05) as was rejection profile ( P = 0.02). Patients with late progressive moderate-severe TR had a significantly higher 2-y mortality than those who had moderate-severe TR immediately. CONCLUSIONS: Overall, our study has shown that in the 2 main groups of interest (early moderate-severe TR and progression from nil-mild to moderate-severe TR), TR is more likely to be the result of significant underling graft dysfunction rather than the cause of it.
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