Plug-and-Play Multimaterial Chaotic Printing/Bioprinting to Produce Radial and Axial Micropatterns in Hydrogel Filaments

Ceballos-González, CF; Bolívar-Monsalve, EJ; Quevedo-Moreno, DA; Chávez-Madero, C; Velásquez-Marín, S; Lam-Aguilar, LL; Solís-Pérez, ÓE; Cantoral-Sánchez, A; Neher, M; Yzar-García, E; Zhang, YS; Gentile, C; Boccaccini, AR; Alvarez, MM; Trujillo-de Santiago, G

Plug-and-Play Multimaterial Chaotic Printing/Bioprinting to Produce Radial and Axial Micropatterns in Hydrogel Filaments

Ceballos-González, CF Bolívar-Monsalve, EJ Quevedo-Moreno, DA Chávez-Madero, C Velásquez-Marín, S Lam-Aguilar, LL Solís-Pérez, ÓE Cantoral-Sánchez, A Neher, M Yzar-García, E Zhang, YS Gentile, C

Boccaccini, AR Alvarez, MM Trujillo-de Santiago, G

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Advanced Materials Technologies, 2023, 8, (17)
Issue Date:: 2023-09-11

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Field	Value	Language
dc.contributor.author	Ceballos-González, CF
dc.contributor.author	Bolívar-Monsalve, EJ
dc.contributor.author	Quevedo-Moreno, DA
dc.contributor.author	Chávez-Madero, C
dc.contributor.author	Velásquez-Marín, S
dc.contributor.author	Lam-Aguilar, LL
dc.contributor.author	Solís-Pérez, ÓE
dc.contributor.author	Cantoral-Sánchez, A
dc.contributor.author	Neher, M
dc.contributor.author	Yzar-García, E
dc.contributor.author	Zhang, YS
dc.contributor.author	Gentile, C https://orcid.org/0000-0002-3689-4275
dc.contributor.author	Boccaccini, AR
dc.contributor.author	Alvarez, MM
dc.contributor.author	Trujillo-de Santiago, G
dc.date.accessioned	2024-04-29T08:15:48Z
dc.date.available	2024-04-29T08:15:48Z
dc.date.issued	2023-09-11
dc.identifier.citation	Advanced Materials Technologies, 2023, 8, (17)
dc.identifier.issn	2365-709X
dc.identifier.issn	2365-709X
dc.identifier.uri	http://hdl.handle.net/10453/178468
dc.description.abstract	Nature abounds with micro-architected materials containing layered multi-material patterns that often transition within the very same monolithic piece. Fabricating these complex materials using current technologies is challenging. Multimaterial chaotic printing is presented—an extrusive printing method based on the use of chaotic advection—that can fabricate microstructured hydrogels with well-defined multimaterial and multilayered micropatterns. Printheads containing internal Kenics static mixing (KSM) elements and top- and lateral-positioned inlets are used to produce a wide repertoire of multilayered hydrogel filaments. In this plug-and-play system, the radial and axial micropatterns can be designed ad hoc by defining the printhead configuration (i.e., the number of KSM elements and inlets, and the inlet positions) and the flow program (i.e., activation/deactivation of the ink-flow through each inlet). Computational fluid dynamics simulations closely predict the microstructure obtained by a given printhead configuration. The application of this platform is illustrated for easy fabrication of fibers with radial microgradients, bacterial ecosystems, structured emulsions, micro-channeled hydrogel filaments, a pre-vascularized tumor niche model, and skeletal muscle-like tissues with axial and radial transitions of bioactive glass compartments. It is envisioned that multimaterial chaotic printing will be a valuable addition to the toolbox of additive manufacturing for the rational fabrication of advanced materials.
dc.language	English
dc.publisher	WILEY
dc.relation.ispartof	Advanced Materials Technologies
dc.relation.isbasedon	10.1002/admt.202202208
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	34 Chemical sciences
dc.subject.classification	40 Engineering
dc.subject.classification	51 Physical sciences
dc.title	Plug-and-Play Multimaterial Chaotic Printing/Bioprinting to Produce Radial and Axial Micropatterns in Hydrogel Filaments
dc.type	Journal Article
utslib.citation.volume	8
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-29T08:15:46Z
pubs.issue	17
pubs.publication-status	Published
pubs.volume	8
utslib.citation.issue	17

Abstract:

Nature abounds with micro-architected materials containing layered multi-material patterns that often transition within the very same monolithic piece. Fabricating these complex materials using current technologies is challenging. Multimaterial chaotic printing is presented—an extrusive printing method based on the use of chaotic advection—that can fabricate microstructured hydrogels with well-defined multimaterial and multilayered micropatterns. Printheads containing internal Kenics static mixing (KSM) elements and top- and lateral-positioned inlets are used to produce a wide repertoire of multilayered hydrogel filaments. In this plug-and-play system, the radial and axial micropatterns can be designed ad hoc by defining the printhead configuration (i.e., the number of KSM elements and inlets, and the inlet positions) and the flow program (i.e., activation/deactivation of the ink-flow through each inlet). Computational fluid dynamics simulations closely predict the microstructure obtained by a given printhead configuration. The application of this platform is illustrated for easy fabrication of fibers with radial microgradients, bacterial ecosystems, structured emulsions, micro-channeled hydrogel filaments, a pre-vascularized tumor niche model, and skeletal muscle-like tissues with axial and radial transitions of bioactive glass compartments. It is envisioned that multimaterial chaotic printing will be a valuable addition to the toolbox of additive manufacturing for the rational fabrication of advanced materials.

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http://hdl.handle.net/10453/178468