Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study.

Ho-Pham, LT; Nguyen, HG; Nguyen-Pham, SQ; Hoang, DK; Tran, TS; Nguyen, TV

Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study.

Ho-Pham, LT Nguyen, HG Nguyen-Pham, SQ Hoang, DK Tran, TS Nguyen, TV

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Publisher:: SPRINGER LONDON LTD
Publication Type:: Journal Article
Citation:: Osteoporos Int, 2023, 34, (8), pp. 1381-1387
Issue Date:: 2023-08

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Field	Value	Language
dc.contributor.author	Ho-Pham, LT
dc.contributor.author	Nguyen, HG
dc.contributor.author	Nguyen-Pham, SQ
dc.contributor.author	Hoang, DK
dc.contributor.author	Tran, TS
dc.contributor.author	Nguyen, TV
dc.date.accessioned	2024-04-29T08:21:53Z
dc.date.available	2023-04-13
dc.date.available	2024-04-29T08:21:53Z
dc.date.issued	2023-08
dc.identifier.citation	Osteoporos Int, 2023, 34, (8), pp. 1381-1387
dc.identifier.issn	0937-941X
dc.identifier.issn	1433-2965
dc.identifier.uri	http://hdl.handle.net/10453/178470
dc.description.abstract	UNLABELLED: Based on the prospective cohort of the Vietnam Osteoporosis Study, we show that bone loss occurred before menopause, and that the loss accelerated in the first 5 years post-menopause. PURPOSE: To define the change in bone mineral density (BMD) among women during the menopausal transition. METHODS: The study involved 1062 women aged 40-59 who were participants of the population-based prospective Vietnam Osteoporosis Study. BMD at the femoral neck (FN), lumbar spine (LS), and whole body scan was measured by DXA. Each woman has had two BMD measurements separated by approximately 2 years, and the rate of BMD change was calculated for each woman. Multivariable linear regression models were used to quantify the association between body composition parameters and the rate of BMD change. RESULTS: At FN, there were 3 phases of BMD change: a slight decline before the age of 45-49 (average loss of 0.51%/year); a substantial decline between the ages of 49 and 54 (average loss of 1.39%/year); and then slowed down between the ages of 54 and 59 (average loss of 0.31%/year). The same trend was also observed at LS: a slight decline (- 0.56%/year) among women aged 45-49; then a significant decline between the ages of 50 and 54 (- 1.33%/year); but then slowed down at - 0.31%/year after the age of 55. Changes in BMD were not significantly associated with changes in lean mass or fat mass. CONCLUSIONS: Although bone loss occurred before menopause, the loss accelerated in the early perimenopausal transition (45-50 years of age). This finding suggests that screening for osteoporosis in women should be considered at the age of 45.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER LONDON LTD
dc.relation.ispartof	Osteoporos Int
dc.relation.isbasedon	10.1007/s00198-023-06757-z
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0903 Biomedical Engineering, 1103 Clinical Sciences, 1117 Public Health and Health Services
dc.subject.classification	Endocrinology & Metabolism
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	4202 Epidemiology
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Middle Aged
dc.subject.mesh	Bone Density
dc.subject.mesh	Perimenopause
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Vietnam
dc.subject.mesh	Osteoporosis
dc.subject.mesh	Lumbar Vertebrae
dc.subject.mesh	Osteoporosis, Postmenopausal
dc.subject.mesh	Femur Neck
dc.subject.mesh	Femur Neck
dc.subject.mesh	Lumbar Vertebrae
dc.subject.mesh	Humans
dc.subject.mesh	Osteoporosis
dc.subject.mesh	Osteoporosis, Postmenopausal
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Perimenopause
dc.subject.mesh	Bone Density
dc.subject.mesh	Middle Aged
dc.subject.mesh	Vietnam
dc.subject.mesh	Female
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Middle Aged
dc.subject.mesh	Bone Density
dc.subject.mesh	Perimenopause
dc.subject.mesh	Prospective Studies
dc.subject.mesh	Vietnam
dc.subject.mesh	Osteoporosis
dc.subject.mesh	Lumbar Vertebrae
dc.subject.mesh	Osteoporosis, Postmenopausal
dc.subject.mesh	Femur Neck
dc.title	Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study.
dc.type	Journal Article
utslib.citation.volume	34
utslib.location.activity	England
utslib.for	0903 Biomedical Engineering
utslib.for	1103 Clinical Sciences
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2024-04-29T08:21:51Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	34
utslib.citation.issue	8

Abstract:

UNLABELLED: Based on the prospective cohort of the Vietnam Osteoporosis Study, we show that bone loss occurred before menopause, and that the loss accelerated in the first 5 years post-menopause. PURPOSE: To define the change in bone mineral density (BMD) among women during the menopausal transition. METHODS: The study involved 1062 women aged 40-59 who were participants of the population-based prospective Vietnam Osteoporosis Study. BMD at the femoral neck (FN), lumbar spine (LS), and whole body scan was measured by DXA. Each woman has had two BMD measurements separated by approximately 2 years, and the rate of BMD change was calculated for each woman. Multivariable linear regression models were used to quantify the association between body composition parameters and the rate of BMD change. RESULTS: At FN, there were 3 phases of BMD change: a slight decline before the age of 45-49 (average loss of 0.51%/year); a substantial decline between the ages of 49 and 54 (average loss of 1.39%/year); and then slowed down between the ages of 54 and 59 (average loss of 0.31%/year). The same trend was also observed at LS: a slight decline (- 0.56%/year) among women aged 45-49; then a significant decline between the ages of 50 and 54 (- 1.33%/year); but then slowed down at - 0.31%/year after the age of 55. Changes in BMD were not significantly associated with changes in lean mass or fat mass. CONCLUSIONS: Although bone loss occurred before menopause, the loss accelerated in the early perimenopausal transition (45-50 years of age). This finding suggests that screening for osteoporosis in women should be considered at the age of 45.

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http://hdl.handle.net/10453/178470