Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Can Alleviate the Proctitis Model Through TLR4/NF-Κb Pathway
- Publication Type:
- Journal Article
- Citation:
- Journal of Cellular and Molecular Anesthesia, 2023, 8, (4), pp. 246-255
- Issue Date:
- 2023-10-01
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Background Proctitis is a significant concern of inflammatory bowel diseases especially ulcerative colitis Exosomes are a new method for treating many diseases by their immunosuppressive and tissue repairing potential Here we tried Mesenchymal stem cells MSCs derived Exosomes for treating the proctitis model of rats Materials and Methods Rats were assigned into four groups sham control group rectal and intraperitoneal exosome injection The proctitis model was induced by rectal administration of 4 acetic acid The exosome was derived from human MSCs isolated from human umbilical cords After seven days rectum samples were assessed for histopathological IHC and PCR analysis Results The histopathologic scores collagen deposition and the expression of NF B TLR4 TNF IL 6 and TGF were decreased in intraperitoneal exosome compared to controls The result was not promising for the rectal administration of exosomes Conclusion Exosomes can suppress the inflammatory response in the proctitis model and improve the rectum s healing process Exosomes can inhabit the NF B TLR4 pathway and downstream pro inflammatory cytokines This study implicates the therapeutic benefits of exomes in treating proctitis 2023 Shahid Beheshti University of Medical Sciences Anesthesiology Research Center All rights reserved
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