Prevalence and variability of HIV/AIDS-associated neurocognitive impairments in Africa: a systematic review and meta-analysis

Mekuriaw, B; Belayneh, Z; Teshome, W; Akalu, Y

Prevalence and variability of HIV/AIDS-associated neurocognitive impairments in Africa: a systematic review and meta-analysis

Mekuriaw, B Belayneh, Z Teshome, W Akalu, Y

Permalink

Publisher:: Springer Nature
Publication Type:: Journal Article
Citation:: BMC Public Health, 2023, 23, (1), pp. 997
Issue Date:: 2023-05-30

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (3.06 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Mekuriaw, B
dc.contributor.author	Belayneh, Z
dc.contributor.author	Teshome, W
dc.contributor.author	Akalu, Y
dc.date.accessioned	2024-05-23T20:19:53Z
dc.date.available	2023-05-19
dc.date.available	2024-05-23T20:19:53Z
dc.date.issued	2023-05-30
dc.identifier.citation	BMC Public Health, 2023, 23, (1), pp. 997
dc.identifier.issn	1471-2458
dc.identifier.issn	1471-2458
dc.identifier.uri	http://hdl.handle.net/10453/179170
dc.description.abstract	AbstractsBackgroundHIV AIDS associated neurocognitive impairments negatively affect treatment adherence viral load suppression CD4 count functionality and the overall quality of life of people with seropositive status However huge variability is observed across primary studies regarding the prevalence and determinants of neurocognitive impairment in people with HIV AIDS This systematic review and meta analysis sought to determine the pooled prevalence of neurocognitive impairment and identify factors contributing to variations in its estimate among people living with HIV AIDS in Africa MethodsA comprehensive literature search of scientific databases Medline PubMed SCOPUS Web of Science PsycINFO and EMBASE was performed from inception onward Google and Google Scholar were also searched for grey literature Research articles available until July 15 2022 were included We used STATA version 14 statistical software for analysis A random effect model was executed to pool the reported prevalence of neurocognitive impairments Subgroup analysis was done to show variations in the prevalence of neurocognitive impairments and factors that might contribute to these variations ResultsA literature search resulted in 8 047 articles After the removal of duplications and thorough evaluation a total of 49 studies were included in the meta analysis The prevalence of HIV AIDS associated neurocognitive impairments was highly variable across studies ranging from 14 to 88 yielding the pooled prevalence of HIV AIDS associated neurocognitive impairment to be 46 34 95 CI 40 32 52 36 and I2 98 5 with a P value of 0 001 ConclusionsA large proportion of people living with HIV AIDS in Africa have HIV AIDS associated neurocognitive impairment This illustrates the need to establish practical approaches to early identification and effective control of HIV AIDS associated neurocognitive impairments However there were variabilities in the reported prevalence of HIV AIDS associated neurocognitive impair
dc.format	Electronic
dc.language	eng
dc.publisher	Springer Nature
dc.relation.ispartof	BMC Public Health
dc.relation.isbasedon	10.1186/s12889-023-15935-x
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1117 Public Health and Health Services
dc.subject.classification	Public Health
dc.subject.classification	4202 Epidemiology
dc.subject.classification	4203 Health services and systems
dc.subject.classification	4206 Public health
dc.subject.mesh	Humans
dc.subject.mesh	HIV Infections
dc.subject.mesh	Prevalence
dc.subject.mesh	Quality of Life
dc.subject.mesh	Acquired Immunodeficiency Syndrome
dc.subject.mesh	Africa
dc.subject.mesh	Humans
dc.subject.mesh	HIV Infections
dc.subject.mesh	Acquired Immunodeficiency Syndrome
dc.subject.mesh	Prevalence
dc.subject.mesh	Quality of Life
dc.subject.mesh	Africa
dc.subject.mesh	Humans
dc.subject.mesh	HIV Infections
dc.subject.mesh	Prevalence
dc.subject.mesh	Quality of Life
dc.subject.mesh	Acquired Immunodeficiency Syndrome
dc.subject.mesh	Africa
dc.title	Prevalence and variability of HIV/AIDS-associated neurocognitive impairments in Africa: a systematic review and meta-analysis
dc.type	Journal Article
utslib.citation.volume	23
utslib.location.activity	England
utslib.for	1117 Public Health and Health Services
utslib.copyright.status	open_access	*
pubs.consider-herdc	true
dc.date.updated	2024-05-23T20:19:47Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	23
utslib.citation.issue	1

Abstract:

AbstractsBackgroundHIV AIDS associated neurocognitive impairments negatively affect treatment adherence viral load suppression CD4 count functionality and the overall quality of life of people with seropositive status However huge variability is observed across primary studies regarding the prevalence and determinants of neurocognitive impairment in people with HIV AIDS This systematic review and meta analysis sought to determine the pooled prevalence of neurocognitive impairment and identify factors contributing to variations in its estimate among people living with HIV AIDS in Africa MethodsA comprehensive literature search of scientific databases Medline PubMed SCOPUS Web of Science PsycINFO and EMBASE was performed from inception onward Google and Google Scholar were also searched for grey literature Research articles available until July 15 2022 were included We used STATA version 14 statistical software for analysis A random effect model was executed to pool the reported prevalence of neurocognitive impairments Subgroup analysis was done to show variations in the prevalence of neurocognitive impairments and factors that might contribute to these variations ResultsA literature search resulted in 8 047 articles After the removal of duplications and thorough evaluation a total of 49 studies were included in the meta analysis The prevalence of HIV AIDS associated neurocognitive impairments was highly variable across studies ranging from 14 to 88 yielding the pooled prevalence of HIV AIDS associated neurocognitive impairment to be 46 34 95 CI 40 32 52 36 and I2 98 5 with a P value of 0 001 ConclusionsA large proportion of people living with HIV AIDS in Africa have HIV AIDS associated neurocognitive impairment This illustrates the need to establish practical approaches to early identification and effective control of HIV AIDS associated neurocognitive impairments However there were variabilities in the reported prevalence of HIV AIDS associated neurocognitive impair

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/179170