Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

Hussain, MS; Moglad, E; Afzal, M; Sharma, S; Gupta, G; Sivaprasad, GV; Deorari, M; Almalki, WH; Kazmi, I; Alzarea, SI; Shahwan, M; Pant, K; Ali, H; Singh, SK; Dua, K; Subramaniyan, V

Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

Hussain, MS Moglad, E Afzal, M Sharma, S Gupta, G Sivaprasad, GV Deorari, M Almalki, WH Kazmi, I Alzarea, SI Shahwan, M Pant, K Ali, H Singh, SK Dua, K

Subramaniyan, V

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Publisher:: Wiley
Publication Type:: Journal Article
Citation:: CNS Neuroscience and Therapeutics, 2024, 30, (5)
Issue Date:: 2024-05

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Field	Value	Language
dc.contributor.author	Hussain, MS
dc.contributor.author	Moglad, E
dc.contributor.author	Afzal, M
dc.contributor.author	Sharma, S
dc.contributor.author	Gupta, G
dc.contributor.author	Sivaprasad, GV
dc.contributor.author	Deorari, M
dc.contributor.author	Almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Alzarea, SI
dc.contributor.author	Shahwan, M
dc.contributor.author	Pant, K
dc.contributor.author	Ali, H
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Subramaniyan, V
dc.date.accessioned	2024-05-27T06:36:15Z
dc.date.available	2024-05-27T06:36:15Z
dc.date.issued	2024-05
dc.identifier.citation	CNS Neuroscience and Therapeutics, 2024, 30, (5)
dc.identifier.issn	1755-5930
dc.identifier.issn	1755-5949
dc.identifier.uri	http://hdl.handle.net/10453/179234
dc.description.abstract	<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence suggests a significant role for disrupted autophagy—a crucial cellular process for maintaining protein and organelle integrity.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This review focuses on the role of non‐coding RNAs (ncRNAs) in modulating autophagy in PD. We conducted a comprehensive review of recent studies to explore how ncRNAs influence autophagy and contribute to PD pathophysiology. Special attention was given to the examination of ncRNAs' regulatory impacts in various PD models and patient samples.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Findings reveal that ncRNAs are pivotal in regulating key processes associated with PD progression, including autophagy, α‐synuclein aggregation, mitochondrial dysfunction, and neuroinflammation. Dysregulation of specific ncRNAs appears to be closely linked to these pathogenic processes.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>ncRNAs hold significant therapeutic potential for addressing autophagy‐related mechanisms in PD. The review highlights innovative therapeutic strategies targeting autophagy‐related ncRNAs and discusses the challenges and prospective directions for developing ncRNA‐based therapies in clinical practice. The insights from this study underline the importance of ncRNAs in the molecular landscape of PD and their potential in novel treatment approaches.</jats:p></jats:sec>
dc.language	en
dc.publisher	Wiley
dc.relation.ispartof	CNS Neuroscience and Therapeutics
dc.relation.isbasedon	10.1111/cns.14763
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1109 Neurosciences, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Pharmacology & Pharmacy
dc.subject.classification	3209 Neurosciences
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis
dc.type	Journal Article
utslib.citation.volume	30
utslib.for	1109 Neurosciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-05-27T06:36:14Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	30
utslib.citation.issue	5

Abstract:

AbstractBackgroundParkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The precise etiology of PD remains unclear, but emerging evidence suggests a significant role for disrupted autophagy—a crucial cellular process for maintaining protein and organelle integrity.MethodsThis review focuses on the role of non‐coding RNAs (ncRNAs) in modulating autophagy in PD. We conducted a comprehensive review of recent studies to explore how ncRNAs influence autophagy and contribute to PD pathophysiology. Special attention was given to the examination of ncRNAs' regulatory impacts in various PD models and patient samples.ResultsFindings reveal that ncRNAs are pivotal in regulating key processes associated with PD progression, including autophagy, α‐synuclein aggregation, mitochondrial dysfunction, and neuroinflammation. Dysregulation of specific ncRNAs appears to be closely linked to these pathogenic processes.ConclusionncRNAs hold significant therapeutic potential for addressing autophagy‐related mechanisms in PD. The review highlights innovative therapeutic strategies targeting autophagy‐related ncRNAs and discusses the challenges and prospective directions for developing ncRNA‐based therapies in clinical practice. The insights from this study underline the importance of ncRNAs in the molecular landscape of PD and their potential in novel treatment approaches.

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