Impact of Aerobic Training on Cardiovascular Function, Fitness, and Patient Reported Outcomes During Anthracycline Chemotherapy: A Case Series in Women With Breast Cancer.

Murray, J; Bennett, H; Selva-Nayagam, S; Joshi, R; Bezak, E; Perry, R

Impact of Aerobic Training on Cardiovascular Function, Fitness, and Patient Reported Outcomes During Anthracycline Chemotherapy: A Case Series in Women With Breast Cancer.

Murray, J

Bennett, H Selva-Nayagam, S Joshi, R Bezak, E Perry, R

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Publisher:: SAGE PUBLICATIONS INC
Publication Type:: Journal Article
Citation:: Integr Cancer Ther, 2023, 22, pp. 15347354231210874
Issue Date:: 2023

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Field	Value	Language
dc.contributor.author	Murray, J https://orcid.org/0000-0002-9585-4951
dc.contributor.author	Bennett, H
dc.contributor.author	Selva-Nayagam, S
dc.contributor.author	Joshi, R
dc.contributor.author	Bezak, E
dc.contributor.author	Perry, R
dc.date.accessioned	2024-06-19T22:24:22Z
dc.date.available	2024-06-19T22:24:22Z
dc.date.issued	2023
dc.identifier.citation	Integr Cancer Ther, 2023, 22, pp. 15347354231210874
dc.identifier.issn	1534-7354
dc.identifier.issn	1552-695X
dc.identifier.uri	http://hdl.handle.net/10453/179581
dc.description.abstract	BACKGROUND: Chemotherapy for breast cancer can increase the risk of cancer therapy related cardiac dysfunction (CTRCD). Exercise has been proposed to prevent CTRCD, however, research to date has indicated high degrees of individual variability following exercise interventions in this population. AIM: This study aimed to explore the impact of regular, individualized aerobic exercise on CTRCD incidence (defined by global longitudinal strain [GLS]) during and immediately upon the completion of dose-dense anthracycline (DDAC) chemotherapy in 5 women with breast cancer. METHODS: Five women receiving DDAC with stage I-III breast cancer enrolled. Participants underwent resting echocardiography and exercise testing before, during, upon the completion of, and 3 months after the completion of DDAC treatment to measure GLS and aerobic fitness (VO2peak). Participants opted-in to an individualized 8-week aerobic exercise intervention (3 sessions per week, 24 sessions total) or standard care for the duration of their DDAC treatment. Data for each participant were presented descriptively. RESULTS: Four of the 5 participants completed the exercise intervention during DDAC treatment (adherence 79.2%-91.7%). Mild asymptomatic CTRCD occurred in 2 of the 4 exercising participants, of whom both were at an increased risk (one was >65 years of age and diagnosed with hypertension, with the other receiving trastuzumab prior to DDAC treatment). Varied responses in VO2peak were observed and did not align with changes in GLS. The only participant not to complete the exercise intervention reported poorer health related quality of life and increased cancer related fatigue at all measurement timepoints. CONCLUSION: This study details the individual variability in cardiovascular responses to exercise that can occur during DDAC treatment in women with breast cancer, which can inform exercise professionals and researchers when designing individualized exercise programs for this population.
dc.format	Print
dc.language	eng
dc.publisher	SAGE PUBLICATIONS INC
dc.relation.ispartof	Integr Cancer Ther
dc.relation.isbasedon	10.1177/15347354231210874
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1104 Complementary and Alternative Medicine, 1112 Oncology and Carcinogenesis
dc.subject.classification	Complementary & Alternative Medicine
dc.subject.classification	3211 Oncology and carcinogenesis
dc.subject.classification	4208 Traditional, complementary and integrative medicine
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Anthracyclines
dc.subject.mesh	Quality of Life
dc.subject.mesh	Antibiotics, Antineoplastic
dc.subject.mesh	Exercise
dc.subject.mesh	Heart Diseases
dc.subject.mesh	Patient Reported Outcome Measures
dc.subject.mesh	Humans
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Heart Diseases
dc.subject.mesh	Anthracyclines
dc.subject.mesh	Antibiotics, Antineoplastic
dc.subject.mesh	Exercise
dc.subject.mesh	Quality of Life
dc.subject.mesh	Female
dc.subject.mesh	Patient Reported Outcome Measures
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Breast Neoplasms
dc.subject.mesh	Anthracyclines
dc.subject.mesh	Quality of Life
dc.subject.mesh	Antibiotics, Antineoplastic
dc.subject.mesh	Exercise
dc.subject.mesh	Heart Diseases
dc.subject.mesh	Patient Reported Outcome Measures
dc.title	Impact of Aerobic Training on Cardiovascular Function, Fitness, and Patient Reported Outcomes During Anthracycline Chemotherapy: A Case Series in Women With Breast Cancer.
dc.type	Journal Article
utslib.citation.volume	22
utslib.location.activity	United States
utslib.for	1104 Complementary and Alternative Medicine
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-06-19T22:24:19Z
pubs.publication-status	Published
pubs.volume	22

Abstract:

BACKGROUND: Chemotherapy for breast cancer can increase the risk of cancer therapy related cardiac dysfunction (CTRCD). Exercise has been proposed to prevent CTRCD, however, research to date has indicated high degrees of individual variability following exercise interventions in this population. AIM: This study aimed to explore the impact of regular, individualized aerobic exercise on CTRCD incidence (defined by global longitudinal strain [GLS]) during and immediately upon the completion of dose-dense anthracycline (DDAC) chemotherapy in 5 women with breast cancer. METHODS: Five women receiving DDAC with stage I-III breast cancer enrolled. Participants underwent resting echocardiography and exercise testing before, during, upon the completion of, and 3 months after the completion of DDAC treatment to measure GLS and aerobic fitness (VO2peak). Participants opted-in to an individualized 8-week aerobic exercise intervention (3 sessions per week, 24 sessions total) or standard care for the duration of their DDAC treatment. Data for each participant were presented descriptively. RESULTS: Four of the 5 participants completed the exercise intervention during DDAC treatment (adherence 79.2%-91.7%). Mild asymptomatic CTRCD occurred in 2 of the 4 exercising participants, of whom both were at an increased risk (one was >65 years of age and diagnosed with hypertension, with the other receiving trastuzumab prior to DDAC treatment). Varied responses in VO2peak were observed and did not align with changes in GLS. The only participant not to complete the exercise intervention reported poorer health related quality of life and increased cancer related fatigue at all measurement timepoints. CONCLUSION: This study details the individual variability in cardiovascular responses to exercise that can occur during DDAC treatment in women with breast cancer, which can inform exercise professionals and researchers when designing individualized exercise programs for this population.

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http://hdl.handle.net/10453/179581