Determining the Role of FKBPL Signalling in Cardiac Fibrosis and Heart Disease

Chhor, Michael

Determining the Role of FKBPL Signalling in Cardiac Fibrosis and Heart Disease

Chhor, Michael

Permalink

Publication Type:: Thesis
Issue Date:: 2023

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download thesisAdobe PDF (10.71 MB)

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Chhor, Michael
dc.date.accessioned	2024-06-20T01:37:12Z
dc.date.available	2024-06-20T01:37:12Z
dc.date.issued	2023
dc.identifier.uri	http://hdl.handle.net/10453/179587
dc.description	University of Technology Sydney. Faculty of Science.	en_US.UTF-8
dc.description.abstract	Cardiovascular Diseases (CVDs) are the leading cause of mortality worldwide and hold a huge socioeconomic burden. Clinical manifestations of CVD are often heterogeneous and caused by various risk factors and co-morbidities that can lead to patient mortality and heart failure (HF). This multifactorial nature of CVD creates difficulty in determining the exact mechanisms of CVD pathophysiology and results in poor patient prognosis. In this thesis, we aim to elucidate key mechanisms in CVD pathophysiology including the emerging role of an immunophilin protein, FK506-binding protein like (FKBPL). Overall, the adverse impact of E-Cigs on cardiovascular health that increases the expression of anti-angiogenic FKBPL and inflammatory markers, was demonstrated. FKBPL shows promising therapeutic target potential in cardiac hypertrophy and fibrosis and could be used in the diagnosis of HFpEF in conjunction with other well-established biomarkers including NT-pro-BNP and Gal-3. Further research is needed to specifically elucidate the role of cardiac remodelling biomarkers including FKBPL in DM population.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/179587/1/thesis.pdf
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	© 2023 Michael Chhor
dc.rights	au.edu.uts.lib/cph
dc.title	Determining the Role of FKBPL Signalling in Cardiac Fibrosis and Heart Disease	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Cardiovascular Diseases (CVDs) are the leading cause of mortality worldwide and hold a huge socioeconomic burden. Clinical manifestations of CVD are often heterogeneous and caused by various risk factors and co-morbidities that can lead to patient mortality and heart failure (HF). This multifactorial nature of CVD creates difficulty in determining the exact mechanisms of CVD pathophysiology and results in poor patient prognosis. In this thesis, we aim to elucidate key mechanisms in CVD pathophysiology including the emerging role of an immunophilin protein, FK506-binding protein like (FKBPL). Overall, the adverse impact of E-Cigs on cardiovascular health that increases the expression of anti-angiogenic FKBPL and inflammatory markers, was demonstrated. FKBPL shows promising therapeutic target potential in cardiac hypertrophy and fibrosis and could be used in the diagnosis of HFpEF in conjunction with other well-established biomarkers including NT-pro-BNP and Gal-3. Further research is needed to specifically elucidate the role of cardiac remodelling biomarkers including FKBPL in DM population.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/179587