3D bioprinting approaches for spinal cord injury repair.

Jiu, J; Liu, H; Li, D; Li, J; Liu, L; Yang, W; Yan, L; Li, S; Zhang, J; Li, X; Li, JJ; Wang, B

3D bioprinting approaches for spinal cord injury repair.

Jiu, J Liu, H Li, D Li, J

Liu, L Yang, W Yan, L Li, S Zhang, J Li, X Li, JJ Wang, B

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Publisher:: IOP Publishing Ltd
Publication Type:: Journal Article
Citation:: Biofabrication, 2024, 16, (3)
Issue Date:: 2024-04-22

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Field	Value	Language
dc.contributor.author	Jiu, J
dc.contributor.author	Liu, H
dc.contributor.author	Li, D
dc.contributor.author	Li, J https://orcid.org/0000-0002-3584-6765
dc.contributor.author	Liu, L
dc.contributor.author	Yang, W
dc.contributor.author	Yan, L
dc.contributor.author	Li, S
dc.contributor.author	Zhang, J
dc.contributor.author	Li, X
dc.contributor.author	Li, JJ
dc.contributor.author	Wang, B
dc.date.accessioned	2024-07-31T23:13:03Z
dc.date.available	2024-04-03
dc.date.available	2024-07-31T23:13:03Z
dc.date.issued	2024-04-22
dc.identifier.citation	Biofabrication, 2024, 16, (3)
dc.identifier.issn	1758-5082
dc.identifier.issn	1758-5090
dc.identifier.uri	http://hdl.handle.net/10453/179887
dc.description.abstract	Regenerative healing of spinal cord injury (SCI) poses an ongoing medical challenge by causing persistent neurological impairment and a significant socioeconomic burden. The complexity of spinal cord tissue presents hurdles to successful regeneration following injury, due to the difficulty of forming a biomimetic structure that faithfully replicates native tissue using conventional tissue engineering scaffolds. 3D bioprinting is a rapidly evolving technology with unmatched potential to create 3D biological tissues with complicated and hierarchical structure and composition. With the addition of biological additives such as cells and biomolecules, 3D bioprinting can fabricate preclinical implants, tissue or organ-like constructs, andin vitromodels through precise control over the deposition of biomaterials and other building blocks. This review highlights the characteristics and advantages of 3D bioprinting for scaffold fabrication to enable SCI repair, including bottom-up manufacturing, mechanical customization, and spatial heterogeneity. This review also critically discusses the impact of various fabrication parameters on the efficacy of spinal cord repair using 3D bioprinted scaffolds, including the choice of printing method, scaffold shape, biomaterials, and biological supplements such as cells and growth factors. High-quality preclinical studies are required to accelerate the translation of 3D bioprinting into clinical practice for spinal cord repair. Meanwhile, other technological advances will continue to improve the regenerative capability of bioprinted scaffolds, such as the incorporation of nanoscale biological particles and the development of 4D printing.
dc.format	Electronic
dc.language	eng
dc.publisher	IOP Publishing Ltd
dc.relation	http://purl.org/au-research/grants/nhmrc/1120249
dc.relation.ispartof	Biofabrication
dc.relation.isbasedon	10.1088/1758-5090/ad3a13
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0903 Biomedical Engineering, 1004 Medical Biotechnology, 1099 Other Technology
dc.subject.classification	3206 Medical biotechnology
dc.subject.classification	4003 Biomedical engineering
dc.subject.mesh	Spinal Cord Injuries
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Bioprinting
dc.subject.mesh	Humans
dc.subject.mesh	Animals
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Spinal Cord Injuries
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Bioprinting
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Spinal Cord Injuries
dc.subject.mesh	Printing, Three-Dimensional
dc.subject.mesh	Bioprinting
dc.subject.mesh	Humans
dc.subject.mesh	Animals
dc.subject.mesh	Tissue Scaffolds
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Biocompatible Materials
dc.title	3D bioprinting approaches for spinal cord injury repair.
dc.type	Journal Article
utslib.citation.volume	16
utslib.location.activity	England
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
utslib.for	1099 Other Technology
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	recently_added	*
dc.date.updated	2024-07-31T23:12:58Z
pubs.issue	3
pubs.publication-status	Published online
pubs.volume	16
utslib.citation.issue	3

Abstract:

Regenerative healing of spinal cord injury (SCI) poses an ongoing medical challenge by causing persistent neurological impairment and a significant socioeconomic burden. The complexity of spinal cord tissue presents hurdles to successful regeneration following injury, due to the difficulty of forming a biomimetic structure that faithfully replicates native tissue using conventional tissue engineering scaffolds. 3D bioprinting is a rapidly evolving technology with unmatched potential to create 3D biological tissues with complicated and hierarchical structure and composition. With the addition of biological additives such as cells and biomolecules, 3D bioprinting can fabricate preclinical implants, tissue or organ-like constructs, andin vitromodels through precise control over the deposition of biomaterials and other building blocks. This review highlights the characteristics and advantages of 3D bioprinting for scaffold fabrication to enable SCI repair, including bottom-up manufacturing, mechanical customization, and spatial heterogeneity. This review also critically discusses the impact of various fabrication parameters on the efficacy of spinal cord repair using 3D bioprinted scaffolds, including the choice of printing method, scaffold shape, biomaterials, and biological supplements such as cells and growth factors. High-quality preclinical studies are required to accelerate the translation of 3D bioprinting into clinical practice for spinal cord repair. Meanwhile, other technological advances will continue to improve the regenerative capability of bioprinted scaffolds, such as the incorporation of nanoscale biological particles and the development of 4D printing.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/179887