Non-Faradaic optoelectrodes for safe electrical neuromodulation.

Chen, J; Liu, Y; Chen, F; Guo, M; Zhou, J; Fu, P; Zhang, X; Wang, X; Wang, H; Hua, W; Chen, J; Hu, J; Mao, Y; Jin, D; Bu, W

Non-Faradaic optoelectrodes for safe electrical neuromodulation.

Chen, J Liu, Y Chen, F Guo, M Zhou, J

Fu, P Zhang, X Wang, X Wang, H Hua, W Chen, J Hu, J Mao, Y Jin, D

Bu, W

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Publisher:: NATURE PORTFOLIO
Publication Type:: Journal Article
Citation:: Nat Commun, 2024, 15, (1), pp. 405
Issue Date:: 2024-01-09

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Field	Value	Language
dc.contributor.author	Chen, J
dc.contributor.author	Liu, Y
dc.contributor.author	Chen, F
dc.contributor.author	Guo, M
dc.contributor.author	Zhou, J https://orcid.org/0000-0002-0605-5745
dc.contributor.author	Fu, P
dc.contributor.author	Zhang, X
dc.contributor.author	Wang, X
dc.contributor.author	Wang, H
dc.contributor.author	Hua, W
dc.contributor.author	Chen, J
dc.contributor.author	Hu, J
dc.contributor.author	Mao, Y
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666
dc.contributor.author	Bu, W
dc.date.accessioned	2024-08-01T03:24:33Z
dc.date.available	2023-12-20
dc.date.available	2024-08-01T03:24:33Z
dc.date.issued	2024-01-09
dc.identifier.citation	Nat Commun, 2024, 15, (1), pp. 405
dc.identifier.issn	2041-1723
dc.identifier.issn	2041-1723
dc.identifier.uri	http://hdl.handle.net/10453/179890
dc.description.abstract	Nanoscale optoelectrodes hold the potential to stimulate optically individual neurons and intracellular organelles, a challenge that demands both a high-density of photoelectron storage and significant charge injection. Here, we report that zinc porphyrin, commonly used in dye-sensitized solar cells, can be self-assembled into nanorods and then coated by TiO2. The J-aggregated zinc porphyrin array enables long-range exciton diffusion and allows for fast electron transfer into TiO2. The formation of TiO2(e-) attracts positive charges around the neuron membrane, contributing to the induction of action potentials. Far-field cranial irradiation of the motor cortex using a 670 nm laser or an 850 nm femtosecond laser can modulate local neuronal firing and trigger motor responses in the hind limb of mice. The pulsed photoelectrical stimulation of neurons in the subthalamic nucleus alleviates parkinsonian symptoms in mice, improving abnormal stepping and enhancing the activity of dopaminergic neurons. Our results suggest injectable nanoscopic optoelectrodes for optical neuromodulation with high efficiency and negligible side effects.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PORTFOLIO
dc.relation.ispartof	Nat Commun
dc.relation.isbasedon	10.1038/s41467-023-44635-8
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Action Potentials
dc.subject.mesh	Cranial Irradiation
dc.subject.mesh	Diffusion
dc.subject.mesh	Dopaminergic Neurons
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Cranial Irradiation
dc.subject.mesh	Diffusion
dc.subject.mesh	Action Potentials
dc.subject.mesh	Dopaminergic Neurons
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Action Potentials
dc.subject.mesh	Cranial Irradiation
dc.subject.mesh	Diffusion
dc.subject.mesh	Dopaminergic Neurons
dc.title	Non-Faradaic optoelectrodes for safe electrical neuromodulation.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	University of Technology Sydney/All Manual Groups
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Institute of Biomedical Materials and Devices (IBMD)
utslib.copyright.status	recently_added	*
dc.date.updated	2024-08-01T03:24:22Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	15
utslib.citation.issue	1

Abstract:

Nanoscale optoelectrodes hold the potential to stimulate optically individual neurons and intracellular organelles, a challenge that demands both a high-density of photoelectron storage and significant charge injection. Here, we report that zinc porphyrin, commonly used in dye-sensitized solar cells, can be self-assembled into nanorods and then coated by TiO2. The J-aggregated zinc porphyrin array enables long-range exciton diffusion and allows for fast electron transfer into TiO2. The formation of TiO2(e-) attracts positive charges around the neuron membrane, contributing to the induction of action potentials. Far-field cranial irradiation of the motor cortex using a 670 nm laser or an 850 nm femtosecond laser can modulate local neuronal firing and trigger motor responses in the hind limb of mice. The pulsed photoelectrical stimulation of neurons in the subthalamic nucleus alleviates parkinsonian symptoms in mice, improving abnormal stepping and enhancing the activity of dopaminergic neurons. Our results suggest injectable nanoscopic optoelectrodes for optical neuromodulation with high efficiency and negligible side effects.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/179890