It provides families with other avenues for treatment when there are no other options Surgeons' perspectives of being part of a precision medicine trial for poor prognosis paediatric cancer patients: A short report.

Daly, R; Hetherington, K; Wadling, BR; Jacobs, C; Karpelowsky, J; Wakefield, CE

It provides families with other avenues for treatment when there are no other options Surgeons' perspectives of being part of a precision medicine trial for poor prognosis paediatric cancer patients: A short report.

Daly, R Hetherington, K Wadling, BR Jacobs, C

Karpelowsky, J Wakefield, CE

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Cancer Med, 2024, 13, (9), pp. e7209
Issue Date:: 2024-05

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Field	Value	Language
dc.contributor.author	Daly, R
dc.contributor.author	Hetherington, K
dc.contributor.author	Wadling, BR
dc.contributor.author	Jacobs, C https://orcid.org/0000-0002-9557-9080
dc.contributor.author	Karpelowsky, J
dc.contributor.author	Wakefield, CE
dc.date.accessioned	2024-08-06T01:38:19Z
dc.date.available	2024-04-11
dc.date.available	2024-08-06T01:38:19Z
dc.date.issued	2024-05
dc.identifier.citation	Cancer Med, 2024, 13, (9), pp. e7209
dc.identifier.issn	2045-7634
dc.identifier.issn	2045-7634
dc.identifier.uri	http://hdl.handle.net/10453/180043
dc.description.abstract	OBJECTIVE: Precision medicine is transforming cancer treatment, yet the perspectives of surgeons who often play a critical role in the delivery of precision medicine remain understudied. METHODS: We conducted semi-structured interviews with 13 surgeons involved in a precision medicine trial for children with poor prognosis cancer. We explored knowledge of genetics, confidence with somatic and germline results, ratings of benefit to stakeholders and willingness to undertake surgical procedures. RESULTS: Surgeons generally had positive attitudes towards precision medicine but expressed concerns about families' unrealistic expectations, mixed opinions on the benefits and the use of research-only biopsies. Most surgeons rated their genetics knowledge as 'good' (69%) and felt 'very confident' in identifying genetic specialists (66%), but 'not confident' (66.6%) in making treatment recommendations. Surgeons' willingness to undertake a procedure was influenced by potential patient benefit. CONCLUSIONS: Our findings support the need for more workforce and training support for surgeons to fully engage with precision medicine.
dc.format	Print
dc.language	eng
dc.publisher	WILEY
dc.relation.ispartof	Cancer Med
dc.relation.isbasedon	10.1002/cam4.7209
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 1112 Oncology and Carcinogenesis
dc.subject.classification	3211 Oncology and carcinogenesis
dc.subject.mesh	Humans
dc.subject.mesh	Precision Medicine
dc.subject.mesh	Surgeons
dc.subject.mesh	Neoplasms
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Prognosis
dc.subject.mesh	Attitude of Health Personnel
dc.subject.mesh	Child
dc.subject.mesh	Health Knowledge, Attitudes, Practice
dc.subject.mesh	Adult
dc.subject.mesh	Family
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Prognosis
dc.subject.mesh	Attitude of Health Personnel
dc.subject.mesh	Health Knowledge, Attitudes, Practice
dc.subject.mesh	Family
dc.subject.mesh	Adult
dc.subject.mesh	Child
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Surgeons
dc.subject.mesh	Precision Medicine
dc.subject.mesh	Humans
dc.subject.mesh	Precision Medicine
dc.subject.mesh	Surgeons
dc.subject.mesh	Neoplasms
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Prognosis
dc.subject.mesh	Attitude of Health Personnel
dc.subject.mesh	Child
dc.subject.mesh	Health Knowledge, Attitudes, Practice
dc.subject.mesh	Adult
dc.subject.mesh	Family
dc.title	It provides families with other avenues for treatment when there are no other options Surgeons' perspectives of being part of a precision medicine trial for poor prognosis paediatric cancer patients: A short report.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	United States
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-08-06T01:38:16Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	9

Abstract:

OBJECTIVE: Precision medicine is transforming cancer treatment, yet the perspectives of surgeons who often play a critical role in the delivery of precision medicine remain understudied. METHODS: We conducted semi-structured interviews with 13 surgeons involved in a precision medicine trial for children with poor prognosis cancer. We explored knowledge of genetics, confidence with somatic and germline results, ratings of benefit to stakeholders and willingness to undertake surgical procedures. RESULTS: Surgeons generally had positive attitudes towards precision medicine but expressed concerns about families' unrealistic expectations, mixed opinions on the benefits and the use of research-only biopsies. Most surgeons rated their genetics knowledge as 'good' (69%) and felt 'very confident' in identifying genetic specialists (66%), but 'not confident' (66.6%) in making treatment recommendations. Surgeons' willingness to undertake a procedure was influenced by potential patient benefit. CONCLUSIONS: Our findings support the need for more workforce and training support for surgeons to fully engage with precision medicine.

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http://hdl.handle.net/10453/180043