Direct oral anticoagulant use in hospitalized patients with atrial fibrillation across body mass index categories: design and rationale for a retrospective cohort study.

Shaikh, F; Wynne, R; L Castelino, R; Inglis, SC; Davidson, PM; Ferguson, C

Direct oral anticoagulant use in hospitalized patients with atrial fibrillation across body mass index categories: design and rationale for a retrospective cohort study.

Shaikh, F Wynne, R L Castelino, R Inglis, SC Davidson, PM Ferguson, C

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Publisher:: SAGE PUBLICATIONS LTD
Publication Type:: Journal Article
Citation:: Ther Adv Drug Saf, 2024, 15, pp. 20420986241227014
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Shaikh, F
dc.contributor.author	Wynne, R
dc.contributor.author	L Castelino, R
dc.contributor.author	Inglis, SC
dc.contributor.author	Davidson, PM
dc.contributor.author	Ferguson, C
dc.date.accessioned	2024-08-06T03:02:41Z
dc.date.available	2024-01-03
dc.date.available	2024-08-06T03:02:41Z
dc.date.issued	2024
dc.identifier.citation	Ther Adv Drug Saf, 2024, 15, pp. 20420986241227014
dc.identifier.issn	2042-0986
dc.identifier.issn	2042-0994
dc.identifier.uri	http://hdl.handle.net/10453/180078
dc.description.abstract	BACKGROUND: Atrial fibrillation (AF) and obesity are common conditions globally; yet, there remains suboptimal pharmacological management contributing to high rates of hospitalization in patients with AF. The altered pathophysiology of both obese and underweight individuals may influence the pharmacology of medications, including those used to manage AF. This, in turn, increases the risk of adverse events and impacts patient risk for stroke and rehospitalization. Despite the well-established complications of obesity, research investigating the relationship between obesity and AF is scant. OBJECTIVES: The primary aim of this study is to describe cardiovascular-related hospitalization in AF patients according to BMI categories. A secondary aim is to describe anticoagulant and antiarrhythmic prescribing practice patterns in patients with AF, according to the BMI category. DESIGN: A retrospective, exploratory descriptive observational cohort study, using routinely collected electronic medical record data from five public hospitals within a single health district, with a population dominantly that is culturally and linguistically diverse, and has a low socioeconomic status. METHODS AND ANALYSIS: Data extraction will include a 24-month period (January 2017 to December 2018) with a 12-month follow-up. All adult (⩾18 years) patients at discharge diagnosed with AF, prescribed any oral anticoagulant and/or oral rate/rhythm control agent, will be eligible for inclusion. ETHICS AND DISSEMINATION: Ethics approval from the health district and the University of Wollongong has been granted. Findings will seek to demonstrate associations between management strategies and patient outcomes, as well as describe patterns of acute care management from prescribers. These data will be used to inform and generate hypotheses for large-scale studies examining the impact of body weight on anticoagulation prescribing at national and global scales.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	SAGE PUBLICATIONS LTD
dc.relation.ispartof	Ther Adv Drug Saf
dc.relation.isbasedon	10.1177/20420986241227014
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1103 Clinical Sciences, 1115 Pharmacology and Pharmaceutical Sciences, 1117 Public Health and Health Services
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.subject.classification	4202 Epidemiology
dc.subject.classification	4203 Health services and systems
dc.title	Direct oral anticoagulant use in hospitalized patients with atrial fibrillation across body mass index categories: design and rationale for a retrospective cohort study.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	England
utslib.for	1103 Clinical Sciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/IMPACCT
pubs.organisational-group	University of Technology Sydney/All Manual Groups
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Digital, Virtual and AI in Health Collaborative (DVAIHC)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated	2024-08-06T03:02:39Z
pubs.publication-status	Published online
pubs.volume	15

Abstract:

BACKGROUND: Atrial fibrillation (AF) and obesity are common conditions globally; yet, there remains suboptimal pharmacological management contributing to high rates of hospitalization in patients with AF. The altered pathophysiology of both obese and underweight individuals may influence the pharmacology of medications, including those used to manage AF. This, in turn, increases the risk of adverse events and impacts patient risk for stroke and rehospitalization. Despite the well-established complications of obesity, research investigating the relationship between obesity and AF is scant. OBJECTIVES: The primary aim of this study is to describe cardiovascular-related hospitalization in AF patients according to BMI categories. A secondary aim is to describe anticoagulant and antiarrhythmic prescribing practice patterns in patients with AF, according to the BMI category. DESIGN: A retrospective, exploratory descriptive observational cohort study, using routinely collected electronic medical record data from five public hospitals within a single health district, with a population dominantly that is culturally and linguistically diverse, and has a low socioeconomic status. METHODS AND ANALYSIS: Data extraction will include a 24-month period (January 2017 to December 2018) with a 12-month follow-up. All adult (⩾18 years) patients at discharge diagnosed with AF, prescribed any oral anticoagulant and/or oral rate/rhythm control agent, will be eligible for inclusion. ETHICS AND DISSEMINATION: Ethics approval from the health district and the University of Wollongong has been granted. Findings will seek to demonstrate associations between management strategies and patient outcomes, as well as describe patterns of acute care management from prescribers. These data will be used to inform and generate hypotheses for large-scale studies examining the impact of body weight on anticoagulation prescribing at national and global scales.

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http://hdl.handle.net/10453/180078