Ferroptosis and circular RNAs: new horizons in cancer therapy.

Bhat, AA; Kukreti, N; Afzal, M; Goyal, A; Thapa, R; Ali, H; Shahwan, M; Almalki, WH; Kazmi, I; Alzarea, SI; Singh, SK; Dua, K; Gupta, G

Ferroptosis and circular RNAs: new horizons in cancer therapy.

Bhat, AA Kukreti, N Afzal, M Goyal, A Thapa, R Ali, H Shahwan, M Almalki, WH Kazmi, I Alzarea, SI Singh, SK Dua, K

Gupta, G

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Publication Type:: Journal Article
Citation:: EXCLI J, 2024, 23, pp. 570-599
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Bhat, AA
dc.contributor.author	Kukreti, N
dc.contributor.author	Afzal, M
dc.contributor.author	Goyal, A
dc.contributor.author	Thapa, R
dc.contributor.author	Ali, H
dc.contributor.author	Shahwan, M
dc.contributor.author	Almalki, WH
dc.contributor.author	Kazmi, I
dc.contributor.author	Alzarea, SI
dc.contributor.author	Singh, SK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gupta, G
dc.date.accessioned	2024-08-06T03:43:49Z
dc.date.available	2024-04-09
dc.date.available	2024-08-06T03:43:49Z
dc.date.issued	2024
dc.identifier.citation	EXCLI J, 2024, 23, pp. 570-599
dc.identifier.issn	1611-2156
dc.identifier.issn	1611-2156
dc.identifier.uri	http://hdl.handle.net/10453/180155
dc.description.abstract	Cancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators to pivotal influencers of ferroptosis in cancer cell lines. The results underscore the significance of circRNAs in modulating molecular pathways that impact crucial aspects of cancer development, including cell survival, proliferation, and metastasis. A detailed analysis delineates these pathways, shedding light on the molecular mechanisms through which circRNAs influence ferroptosis. Building upon recent experimental findings, the study evaluates the therapeutic potential of targeting circRNAs to induce ferroptosis. By identifying specific circRNAs associated with the etiology of cancer, this analysis paves the way for the development of targeted therapeutics that exploit vulnerabilities in cancer cells. This review consolidates the existing understanding of ferroptosis and circRNAs, emphasizing their role in cancer therapy and providing impetus for ongoing research in this dynamic field. See also the graphical abstract(Fig. 1).
dc.format	Electronic-eCollection
dc.language	eng
dc.relation.ispartof	EXCLI J
dc.relation.isbasedon	10.17179/excli2024-7005
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Toxicology
dc.title	Ferroptosis and circular RNAs: new horizons in cancer therapy.
dc.type	Journal Article
utslib.citation.volume	23
utslib.location.activity	Germany
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-08-06T03:43:45Z
pubs.publication-status	Published online
pubs.volume	23

Abstract:

Cancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators to pivotal influencers of ferroptosis in cancer cell lines. The results underscore the significance of circRNAs in modulating molecular pathways that impact crucial aspects of cancer development, including cell survival, proliferation, and metastasis. A detailed analysis delineates these pathways, shedding light on the molecular mechanisms through which circRNAs influence ferroptosis. Building upon recent experimental findings, the study evaluates the therapeutic potential of targeting circRNAs to induce ferroptosis. By identifying specific circRNAs associated with the etiology of cancer, this analysis paves the way for the development of targeted therapeutics that exploit vulnerabilities in cancer cells. This review consolidates the existing understanding of ferroptosis and circRNAs, emphasizing their role in cancer therapy and providing impetus for ongoing research in this dynamic field. See also the graphical abstract(Fig. 1).

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http://hdl.handle.net/10453/180155