Platinum-based metal complexes as chloride transporters that trigger apoptosis.

Wang, P; Fares, M; Eladwy, RA; Bhuyan, DJ; Wu, X; Lewis, W; Loeb, SJ; Macreadie, LK; Gale, PA

Platinum-based metal complexes as chloride transporters that trigger apoptosis.

Wang, P Fares, M Eladwy, RA Bhuyan, DJ Wu, X Lewis, W Loeb, SJ Macreadie, LK Gale, PA

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Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: Chem Sci, 2024, 15, (29), pp. 11584-11593
Issue Date:: 2024-07-24

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Field	Value	Language
dc.contributor.author	Wang, P
dc.contributor.author	Fares, M
dc.contributor.author	Eladwy, RA
dc.contributor.author	Bhuyan, DJ
dc.contributor.author	Wu, X
dc.contributor.author	Lewis, W
dc.contributor.author	Loeb, SJ
dc.contributor.author	Macreadie, LK
dc.contributor.author	Gale, PA
dc.date.accessioned	2024-08-21T03:40:11Z
dc.date.available	2024-06-21
dc.date.available	2024-08-21T03:40:11Z
dc.date.issued	2024-07-24
dc.identifier.citation	Chem Sci, 2024, 15, (29), pp. 11584-11593
dc.identifier.issn	2041-6520
dc.identifier.issn	2041-6539
dc.identifier.uri	http://hdl.handle.net/10453/180439
dc.description.abstract	In this paper we demonstrate that Pt(ii) complexes can function as efficient transmembrane chloride transporters. A series of Pt(ii) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation	http://purl.org/au-research/grants/arc/DP200100453
dc.relation.ispartof	Chem Sci
dc.relation.isbasedon	10.1039/d4sc02115k
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	03 Chemical Sciences
dc.subject.classification	34 Chemical sciences
dc.title	Platinum-based metal complexes as chloride transporters that trigger apoptosis.
dc.type	Journal Article
utslib.citation.volume	15
utslib.location.activity	England
utslib.for	03 Chemical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Strength - TKC - The Kidman Centre
pubs.organisational-group	University of Technology Sydney/All Manual Groups
pubs.organisational-group	University of Technology Sydney/All Manual Groups/The Kidman Centre (TKC)
utslib.copyright.status	open_access	*
dc.rights.license	This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/
dc.date.updated	2024-08-21T03:40:06Z
pubs.issue	29
pubs.publication-status	Published online
pubs.volume	15
utslib.citation.issue	29

Abstract:

In this paper we demonstrate that Pt(ii) complexes can function as efficient transmembrane chloride transporters. A series of Pt(ii) metal complexes with urea-appended isoquinoline ligands were synthesised and operate via classical hydrogen bonding interactions rather than ligand exchange. A number of the complexes exhibited potent transmembrane chloride activity in vesicle studies, while also showing strong antiproliferative activity in cisplatin-resistant cell lines via induction of apoptosis and inhibition of intracellular ROS.

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http://hdl.handle.net/10453/180439