Chronic maternal exposure to low-dose PM2.5 impacts cognitive outcomes in a sex-dependent manner.
Oliver, BG
Huang, X
Yarak, R
Bai, X
Wang, Q
Zakarya, R
Reddy, KD
Donovan, C
Kim, RY
Morkaya, J
Wang, B
Lung Chan, Y
Saad, S
Faiz, A
Reyk, DV
Verkhratsky, A
Yi, C
Chen, H
- Publisher:
- Elsevier BV
- Publication Type:
- Journal Article
- Citation:
- Environ Int, 2024, 191, pp. 108971
- Issue Date:
- 2024-08-20
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Oliver, BG | |
dc.contributor.author | Huang, X | |
dc.contributor.author | Yarak, R | |
dc.contributor.author | Bai, X | |
dc.contributor.author | Wang, Q | |
dc.contributor.author |
Zakarya, R https://orcid.org/0000-0002-9259-9369 |
|
dc.contributor.author | Reddy, KD | |
dc.contributor.author |
Donovan, C https://orcid.org/0000-0003-4558-329X |
|
dc.contributor.author | Kim, RY | |
dc.contributor.author | Morkaya, J | |
dc.contributor.author | Wang, B | |
dc.contributor.author | Lung Chan, Y | |
dc.contributor.author | Saad, S | |
dc.contributor.author |
Faiz, A https://orcid.org/0000-0003-1740-3538 |
|
dc.contributor.author | Reyk, DV | |
dc.contributor.author | Verkhratsky, A | |
dc.contributor.author | Yi, C | |
dc.contributor.author |
Chen, H https://orcid.org/0000-0001-6883-3752 |
|
dc.date.accessioned | 2024-09-03T02:44:32Z | |
dc.date.available | 2024-08-19 | |
dc.date.available | 2024-09-03T02:44:32Z | |
dc.date.issued | 2024-08-20 | |
dc.identifier.citation | Environ Int, 2024, 191, pp. 108971 | |
dc.identifier.issn | 0160-4120 | |
dc.identifier.issn | 1873-6750 | |
dc.identifier.uri | http://hdl.handle.net/10453/180594 | |
dc.description.abstract | There is no safe level of air pollution for human health. Traffic-related particulate matter (PM2.5) is a major in-utero toxin, mechanisms of action of which are not fully understood. BALB/c dams were exposed to an Australian level of traffic PM2.5 (5 µg/mouse/day, intranasal, 6 weeks before mating, during gestation and lactation). Male offspring had reduced memory in adulthood, whereas memory was normal in female littermates, similar to human responses. Maternal PM2.5 exposure resulted in oxidative stress and abnormal mitochondria in male, but not female, brains. RNA-sequencing analysis showed unique sex-related changes in newborn brains. Two X-chromosome-linked histone lysine demethylases, Kdm6a and Kdm5c, demonstrated higher expression in female compared to male littermates, in addition to upregulated genes with known functions to support mitochondrial function, synapse growth and maturation, cognitive function, and neuroprotection. No significant changes in Kdm6a and Kdm5c were found in male littermates, nor other genes, albeit significantly impaired memory function after birth. In primary foetal cortical neurons, PM2.5 exposure suppressed neuron and synaptic numbers and induced oxidative stress, which was prevented by upregulation of Kdm6a or Kdm5c. Therefore, timely epigenetic adaptation by histone demethylation to open DNA for translation before birth may be the key to protecting females against prenatal PM2.5 exposure-induced neurological disorders, which fail to occur in males associated with their poor cognitive outcomes. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation | http://purl.org/au-research/grants/nhmrc/APP1158186 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1158186 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/GNT1158186 | |
dc.relation.ispartof | Environ Int | |
dc.relation.isbasedon | 10.1016/j.envint.2024.108971 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.classification | Environmental Sciences | |
dc.title | Chronic maternal exposure to low-dose PM2.5 impacts cognitive outcomes in a sex-dependent manner. | |
dc.type | Journal Article | |
utslib.citation.volume | 191 | |
utslib.location.activity | Netherlands | |
pubs.organisational-group | University of Technology Sydney | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | University of Technology Sydney/Strength - CFI - Centre for Inflammation | |
pubs.organisational-group | University of Technology Sydney/All Manual Groups | |
pubs.organisational-group | University of Technology Sydney/All Manual Groups/Centre for Inflammation (CFI) | |
utslib.copyright.status | open_access | * |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.date.updated | 2024-09-03T02:44:30Z | |
pubs.publication-status | Published online | |
pubs.volume | 191 |
Abstract:
There is no safe level of air pollution for human health. Traffic-related particulate matter (PM2.5) is a major in-utero toxin, mechanisms of action of which are not fully understood. BALB/c dams were exposed to an Australian level of traffic PM2.5 (5 µg/mouse/day, intranasal, 6 weeks before mating, during gestation and lactation). Male offspring had reduced memory in adulthood, whereas memory was normal in female littermates, similar to human responses. Maternal PM2.5 exposure resulted in oxidative stress and abnormal mitochondria in male, but not female, brains. RNA-sequencing analysis showed unique sex-related changes in newborn brains. Two X-chromosome-linked histone lysine demethylases, Kdm6a and Kdm5c, demonstrated higher expression in female compared to male littermates, in addition to upregulated genes with known functions to support mitochondrial function, synapse growth and maturation, cognitive function, and neuroprotection. No significant changes in Kdm6a and Kdm5c were found in male littermates, nor other genes, albeit significantly impaired memory function after birth. In primary foetal cortical neurons, PM2.5 exposure suppressed neuron and synaptic numbers and induced oxidative stress, which was prevented by upregulation of Kdm6a or Kdm5c. Therefore, timely epigenetic adaptation by histone demethylation to open DNA for translation before birth may be the key to protecting females against prenatal PM2.5 exposure-induced neurological disorders, which fail to occur in males associated with their poor cognitive outcomes.
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